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              <text>E8–E8</text>
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                <text>Chronic lymphocytic leukemia-associated membranous glomerulopathy: remission with fludarabine.</text>
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                <text>American journal of kidney diseases : the official journal of the National Kidney Foundation</text>
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                <text>Antineoplastic Agents/*therapeutic use; B-Cell/*complications; Biopsy; Chronic; Female; Glomerulonephritis; Humans; Kidney/pathology; Leukemia; Lymphocytic; Membranous/diagnosis/*drug therapy/etiology; Vidarabine/*analogs &amp; derivatives/therapeutic use</text>
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                <text>Butty H; Asfoura J; Cortese F; Doyle M; Rutecki G</text>
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                <text>In some individuals, chronic lymphocytic leukemia (CLL) may be associated with glomerular disease from membranous nephropathy with resultant nephrotic syndrome. CLL is characterized by abnormal immunoregulation with a malignant clonal proliferation of lymphocytes. The association between the abnormal clone and nephrotic syndrome is suggested in some cases by the remission of proteinuria with a reduction in abnormal lymphocyte number after treatment with antineoplastic agents. For the first time, we describe a patient with CLL and associated membranous glomerulopathy whose nephrotic syndrome remitted after treatment with fludarabine, a new purine analogue used in the treatment of refractory CLL.</text>
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