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Text
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URL Address
<a href="http://doi.org/10.1097/MOP.0000000000000092" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/MOP.0000000000000092</a>
Pages
292–298
Issue
3
Volume
26
Dublin Core
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Title
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Use of procalcitonin for the prediction and treatment of acute bacterial infection in children.
Publisher
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Current opinion in pediatrics
Date
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2014
2014-06
Subject
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Anti-Bacterial Agents/*administration & dosage; Antibiotics – Administration and Dosage; Bacteremia – Blood; Bacteremia – Diagnosis; Bacteremia/blood/diagnosis; Bacterial Infections – Blood; Bacterial Infections – Diagnosis; Bacterial Infections – Drug Therapy; Bacterial Infections/blood/*diagnosis/drug therapy; Biological Markers – Blood; Biomarkers/blood; Calcitonin – Blood; Calcitonin Gene-Related Peptide; Calcitonin/*blood; Child; Humans; Inflammation – Blood; Inflammation – Diagnosis; Inflammation/blood/diagnosis; Predictive Value of Tests; Preschool; Prognosis; Protein Precursors – Blood; Protein Precursors/*blood; Sensitivity and Specificity
Creator
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Pierce Richard; Bigham Michael T; Giuliano John S Jr
Description
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PURPOSE OF REVIEW: Procalcitonin (PCT) is increasingly utilized to determine the presence of infection or to guide antibiotic therapy. This review will highlight the diagnostic and prognostic utility of serum PCT in children. RECENT FINDINGS: Recent studies endorse the use of serum PCT to detect invasive infection, to differentiate sepsis from noninfectious systemic inflammatory response syndrome, and to guide antibiotic therapy. Typical values for maximal sensitivity and specificity are less than 0.5 ng/ml for noninfectious inflammation and greater than 2.0 ng/ml for bacterial sepsis. PCT appears to be a reliable indicator of infection. PCT has performed better than C-reactive protein in some settings, though pediatric comparative data are lacking. PCT may aid in diagnosing infection in challenging patient populations such as those with sickle cell disease, congenital heart defects, neutropenia, and indwelling central venous catheters. Antibiotic therapy tailored to serial PCT measurements may shorten the antibiotic exposure without increasing treatment failure. SUMMARY: PCT is a reliable serum marker for determining the presence or absence of invasive bacterial infection and response to antibiotic therapy. Tailoring antibiotics to PCT levels may reduce the duration of therapy without increasing treatment failure, but more research is needed in children.
Identifier
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<a href="http://doi.org/10.1097/MOP.0000000000000092" target="_blank" rel="noreferrer noopener">10.1097/MOP.0000000000000092</a>
Rights
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2014
Anti-Bacterial Agents/*administration & dosage
Antibiotics – Administration and Dosage
Bacteremia – Blood
Bacteremia – Diagnosis
Bacteremia/blood/diagnosis
Bacterial Infections – Blood
Bacterial Infections – Diagnosis
Bacterial Infections – Drug Therapy
Bacterial Infections/blood/*diagnosis/drug therapy
Bigham Michael T
Biological Markers – Blood
Biomarkers/blood
Calcitonin – Blood
Calcitonin Gene-Related Peptide
Calcitonin/*blood
Child
Current opinion in pediatrics
Giuliano John S Jr
Humans
Inflammation – Blood
Inflammation – Diagnosis
Inflammation/blood/diagnosis
Pierce Richard
Predictive Value of Tests
Preschool
Prognosis
Protein Precursors – Blood
Protein Precursors/*blood
Sensitivity and Specificity