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Text
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URL Address
<a href="http://doi.org/10.1016/j.ntt.2018.05.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2018.05.004</a>
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Pages
66-71
Volume
68
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Title
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Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters
Publisher
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Neurotoxicology and Teratology
Date
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2018
2018-07
Subject
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C. elegans; Toxicology; Neurosciences & Neurology; parkinsons-disease; exposure; degeneration; costa-rica; pregnant-women; antidepressant; caenorhabditis-elegans; infants environmental-health; leads; Mancozeb; Mancozeb; Manzate; Mn/Zn ethylene-bis-dithiocarbamate; Neurotransmitter transporters; Neurotransmitters
Creator
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Montgomery K; Corona C; Frye R; Barnett R; Bailey A; Fitsanakis V A
Description
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Mancozeb (MZ), an organic-metal fungicide used predominantly on vegetables and fruits, has been linked to neurodegeneration and behavioral disruptions in a variety of organisms, including humans. Both gamma-aminobutyric acid and dopamine neurons appear to be more vulnerable to MZ exposure than other neuronal populations. Based on these observations, we hypothesized that MZ may be differentially transported into these cells through their presynaptic neurotransmitter transporters. To test this, we pretreated Caenorhabditis elegans with transporter antagonists followed by exposure to various concentrations of MZ. Potential neuroprotection was monitored via green fluorescence associated with various neuron populations in transgenic worm strains. Neurodegeneration associated with subacute MZ treatment (30 min) was not altered by transporter antagonist pretreatment. On the other hand, pretreatment with a dopamine transporter antagonist (GBR12909) appeared to protect dopaminergic neurons from chronic (24 h) MZ treatment. These results are consistent with other reports that dopamine transporter levels or activity may modulate toxicity for neurotoxicants.
Identifier
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<a href="http://doi.org/10.1016/j.ntt.2018.05.004" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2018.05.004</a>
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Journal Article or Conference Abstract Publication
2018
antidepressant
Bailey A
Barnett R
C. elegans
caenorhabditis-elegans
Corona C
costa-rica
degeneration
Department of Pharmaceutical Sciences
exposure
Fitsanakis V A
Frye R
infants environmental-health
Journal Article or Conference Abstract Publication
leads
Mancozeb
Manzate
Mn/Zn ethylene-bis-dithiocarbamate
Montgomery K
NEOMED College of Pharmacy
Neurosciences & Neurology
Neurotoxicology and teratology
Neurotransmitter transporters
NEUROTRANSMITTERS
parkinsons-disease
pregnant-women
Toxicology