1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0196154" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0196154</a>
Pages
e0196154–e0196154
Issue
5
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-7
Subject
The topic of the resource
Animals; *Metabolomics; Chiroptera/*physiology; Feces/*chemistry; Longevity/*physiology
Creator
An entity primarily responsible for making the resource
Ball Hope C; Levari-Shariati Shiva; Cooper Lisa Noelle; Aliani Michel
Description
An account of the resource
Vespertilionid bats (Mammalia: Order Chiroptera) live 3-10 times longer than other mammals of an equivalent body size. At present, nothing is known of how bat fecal metabolic profiles shift with age in any taxa. This study established the feasibility of using a non-invasive, fecal metabolomics approach to examine age-related differences in the fecal metabolome of young and elderly adult big brown bats (Eptesicus fuscus) as an initial investigation into using metabolomics for age determination. Samples were collected from captive, known-aged big brown bats (Eptesicus fuscus) from 1 to over 14 years of age: these two ages represent age groups separated by approximately 75% of the known natural lifespan of this taxon. Results showed 41 metabolites differentiated young (n = 22) and elderly (n = 6) Eptesicus. Significant differences in metabolites between young and elderly bats were associated with tryptophan metabolism and incomplete protein digestion. Results support further exploration of the physiological mechanisms bats employ to achieve exceptional longevity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0196154" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0196154</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Metabolomics
2018
Aliani Michel
Animals
Ball Hope C
Chiroptera/*physiology
Cooper Lisa Noelle
Department of Anatomy & Neurobiology
Feces/*chemistry
Levari-Shariati Shiva
Longevity/*physiology
NEOMED College of Medicine
PloS one
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neurobiolaging.2018.03.021" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neurobiolaging.2018.03.021</a>
Pages
148–158
Volume
67
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence of Wnt/beta-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease.
Publisher
An entity responsible for making the resource available
Neurobiology of aging
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-07
Subject
The topic of the resource
*Alzheimer's disease; *Beta catenin; *Bone mineral density; *Neurodegeneration; *Tauopathy; *Wnt proteins; *Wnt Signaling Pathway; Alzheimer Disease/*genetics/*metabolism; Animal; Animals; beta Catenin/metabolism; Bone and Bones/*metabolism; Bone Density; Bone Remodeling/genetics; Brain/*metabolism; Disease Models; Female; Gene Expression; Male; Mice; Osteogenesis/genetics; Osteoporosis/etiology/genetics; tau Proteins/*metabolism; Tauopathies/genetics/*metabolism; Wnt Proteins/metabolism
Creator
An entity primarily responsible for making the resource
Dengler-Crish Christine M; Ball Hope C; Lin Li; Novak Kimberly M; Cooper Lisa Noelle
Description
An account of the resource
Low bone mineral density (BMD) is a significant comorbidity in Alzheimer's disease (AD) and may reflect systemic regulatory pathway dysfunction. Low BMD has been identified in several AD mouse models selective for amyloid-beta or tau pathology, but these deficits were attributed to diverse mechanisms. In this study, we identified common pathophysiological mechanisms accounting for bone loss and neurodegeneration in the htau mouse, a tauopathy model with an early low BMD phenotype. We investigated the Wnt/beta-catenin pathway-a cellular signaling cascade linked to both bone loss and neuropathology. We showed that low BMD persisted in male htau mice aged from 6 to 14 months, remaining significantly lower than tau-null and C57BL/6J controls. Osteogenic gene expression in female and male htau mice was markedly reduced from controls, indicating impaired bone remodeling. In both the bone and brain, htau mice showed alterations in Wnt/beta-catenin signaling genes suggestive of increased inhibition of this pathway. These findings implicate dysfunctional Wnt signaling as a potential target for addressing bone loss in AD.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neurobiolaging.2018.03.021" target="_blank" rel="noreferrer noopener">10.1016/j.neurobiolaging.2018.03.021</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alzheimer's disease
*Beta catenin
*Bone mineral density
*neurodegeneration
*Tauopathy
*Wnt proteins
*Wnt Signaling Pathway
2018
Alzheimer Disease/*genetics/*metabolism
Animal
Animals
Ball Hope C
beta Catenin/metabolism
Bone and Bones/*metabolism
Bone Density
Bone Remodeling/genetics
Brain/*metabolism
Cooper Lisa Noelle
Dengler-Crish Christine M
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Disease Models
Female
Gene Expression
Lin Li
Male
Mice
NEOMED College of Medicine
NEOMED College of Pharmacy
Neurobiology of aging
Novak Kimberly M
Osteogenesis/genetics
Osteoporosis/etiology/genetics
tau Proteins/*metabolism
Tauopathies/genetics/*metabolism
Wnt Proteins/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ar.23125" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ar.23125</a>
Pages
1416–1423
Issue
8
Volume
298
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Seasonal and Ontogenetic Variation in Subcutaneous Adipose Of the Bowhead Whale (Balaena mysticetus).
Publisher
An entity responsible for making the resource available
Anatomical record (Hoboken, N.J. : 2007)
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-08
Subject
The topic of the resource
*Biological Evolution; *Seasons; Adaptation; Adipocytes/*cytology; adipose; Age Factors; Animals; Autopsy; blubber; bowhead; Bowhead Whale/*anatomy & histology/psychology; Cell Size; Feeding Behavior; Female; Male; ontogeny; Physiological; seasonal variation; Subcutaneous Fat/*cytology
Creator
An entity primarily responsible for making the resource
Ball Hope C; Stavarz Madeline; Oldaker Jonathan; Usip Sharon; Londraville Richard L; George John C; Thewissen Johnannes G M; Duff Robert Joel
Description
An account of the resource
Cetacean evolution was shaped by an extraordinary land-to-sea transition in which the ancestors of whales became fully aquatic. As part of this transition, these mammals evolved unusually thick blubber which acts as a metabolic reservoir as well as an insulator and provides buoyancy and streamlining. This study describes blubber stratification and correlates it to seasonal variation, feeding patterns, and ontogeny in an arctic-adapted mysticete, the bowhead whale (Balaena mysticetus). Bowheads are unique among mammals for possessing the largest known blubber stores. We found that adipocyte numbers in bowheads, like other mammals, do not vary with season or feeding pattern but that adipocyte size and structural fiber densities do vary with blubber depth.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/ar.23125" target="_blank" rel="noreferrer noopener">10.1002/ar.23125</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Biological Evolution
*Seasons
2015
Adaptation
Adipocytes/*cytology
adipose
Age Factors
Anatomical record (Hoboken, N.J. : 2007)
Animals
Autopsy
Ball Hope C
Blubber
bowhead
Bowhead Whale/*anatomy & histology/psychology
Cell Size
Department of Anatomy & Neurobiology
Duff Robert Joel
Feeding Behavior
Female
George John C
Londraville Richard L
Male
NEOMED College of Medicine
Oldaker Jonathan
ontogeny
Physiological
seasonal variation
Stavarz Madeline
Subcutaneous Fat/*cytology
Thewissen Johnannes G M
Usip Sharon