1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s10162-020-00782-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10162-020-00782-z</a> ISSN 1438-7573 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s10162-020-00782-z" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s10162-020-00782-z</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number January 2021 List NEOMED College NEOMED College of Medicine NEOMED Department Department of Anatomy & Neurobiology Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Early physiological and cellular indicators of cisplatin-induced ototoxicity. Publisher An entity responsible for making the resource available Journal of the Association for Research in Otolaryngology : JARO Date A point or period of time associated with an event in the lifecycle of the resource 2021 2021-01-07 Subject The topic of the resource cisplatin; hair cells; ototoxicity; Schwann cell; spiral ganglion neuron Creator An entity primarily responsible for making the resource Chen Y; Bielefeld EC; Mellott JG; Wang W; Mafi Amir M; Yamoah EN; Bao J Description An account of the resource Cisplatin chemotherapy often causes permanent hearing loss, which leads to a multifaceted decrease in quality of life. Identification of early cisplatin-induced cochlear damage would greatly improve clinical diagnosis and provide potential drug targets to prevent cisplatin's ototoxicity. With improved functional and immunocytochemical assays, a recent seminal discovery revealed that synaptic loss between inner hair cells and spiral ganglion neurons is a major form of early cochlear damage induced by noise exposure or aging. This breakthrough discovery prompted the current study to determine early functional, cellular, and molecular changes for cisplatin-induced hearing loss, in part to determine if synapse injury is caused by cisplatin exposure. Cisplatin was delivered in one to three treatment cycles to both male and female mice. After the cisplatin treatment of three cycles, threshold shift was observed across frequencies tested like previous studies. After the treatment of two cycles, beside loss of outer hair cells and an increase in high-frequency hearing thresholds, a significant latency delay of auditory brainstem response wave 1 was observed, including at a frequency region where there were no changes in hearing thresholds. The wave 1 latency delay was detected as early cisplatin-induced ototoxicity after only one cycle of treatment, in which no significant threshold shift was found. In the same mice, mitochondrial loss in the base of the cochlea and declining mitochondrial morphometric health were observed. Thus, we have identified early spiral ganglion-associated functional and cellular changes after cisplatin treatment that precede significant threshold shift. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s10162-020-00782-z" target="_blank" rel="noreferrer noopener">10.1007/s10162-020-00782-z</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2021 Bao J Bielefeld EC Chen Y cisplatin Department of Anatomy & Neurobiology Hair Cells January 2021 List Journal of the Association for Research in Otolaryngology : JARO journalArticle Mafi Amir M Mellott JG NEOMED College of Medicine Ototoxicity Schwann cell Spiral ganglion neuron Wang W Yamoah EN