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Text
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URL Address
<a href="http://doi.org/10.1002/jcb.25924" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcb.25924</a>
Pages
2744–2751
Issue
9
Volume
118
Dublin Core
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Title
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Renal Calcium Oxalate Deposits Induce a Pro-Atherosclerotic and Pro-Osteoporotic Response in Mice.
Publisher
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Journal of cellular biochemistry
Date
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2017
2017-09
Subject
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*CARDIOVASCULAR DISEASE; *Gene Expression Regulation; *KIDNEY STONES; *METABOLIC BONE DISEASE; *MURINE MODEL; Animal; Animals; Atherosclerosis/*metabolism/pathology; Calcium Oxalate/*metabolism; Disease Models; Kidney/*metabolism/pathology; Mice; Osteoporosis/*metabolism/pathology; Urinary Calculi/*metabolism/pathology
Creator
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Kusumi Kirsten; Barr-Beare Evan; Saxena Vijay; Safedi Fayez; Schwaderer Andrew
Description
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Urinary stone disease (USD) is increasing in adult and pediatric populations. Adult and pediatric studies have demonstrated decreased bone mineral density and increased fracture rates. USD has also been independently linked to increased rates of myocardial infarction and cerebral vascular accidents. Although USD is a multisystem disorder involving the kidneys, bone, and vasculature, the molecular mechanisms linking these three organs remain unknown. Calcium oxalate nephropathy was induced in C57BL/6J mice with intra-peritoneal (ip) injection of sodium glyoxolate. Half of each kidney underwent Pizzalato staining and half was snap frozen for RNA extraction. RT(2) Profiler Mouse Atherosclerosis, Osteoporosis, and Calcium Signaling PCR Arrays (Qiagen) were performed. Only results that passed quality checks in PCR array reproducibility and genomic DNA contamination were included. Genes had to show at least fourfold differential expression and P \textless 0.01 to be considered significant. Atherosclerosis array showed upregulation of 19 genes by fourfold, 10 of which were \textgreater/=10-fold. All 19 had P 10-fold increase. All 10 have P /=10-fold. All 10 have P
Identifier
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<a href="http://doi.org/10.1002/jcb.25924" target="_blank" rel="noreferrer noopener">10.1002/jcb.25924</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*CARDIOVASCULAR DISEASE
*Gene Expression Regulation
*KIDNEY STONES
*METABOLIC BONE DISEASE
*MURINE MODEL
2017
Animal
Animals
Atherosclerosis/*metabolism/pathology
Barr-Beare Evan
Calcium Oxalate/*metabolism
Disease Models
Journal of cellular biochemistry
Kidney/*metabolism/pathology
Kusumi Kirsten
Mice
Osteoporosis/*metabolism/pathology
Safedi Fayez
Saxena Vijay
Schwaderer Andrew
Urinary Calculi/*metabolism/pathology