1
40
7
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bbr.2019.112456" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bbr.2019.112456</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
112456
Volume
381
ISSN
1872-7549
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Update Year & Number
January 2020 Update
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in cognitive performance and alcohol consumption in High Alcohol-Drinking (HAD-1) rats
Publisher
An entity responsible for making the resource available
Behavioural Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-12-28
Subject
The topic of the resource
Alcohol use disorders; Attention; Exploratory behavior; Novel object recognition; Object recognition test; Selectively bred high alcohol-drinking rats
Creator
An entity primarily responsible for making the resource
Mittal N; Fleming S M; Martinez A; Thakore N; Bell R L; Maddox W T; Schallert T; Duvauchelle C L
Description
An account of the resource
Excessive alcohol (ethanol) consumption negatively impacts social, emotional, as well as cognitive function and well-being. Thus, identifying behavioral and/or biological predictors of excessive ethanol consumption is important for developing prevention and treatment strategies against alcohol use disorders (AUDs). Sex differences in alcohol consumption patterns are observed in humans, primates, and rodents. Selectively bred high alcohol-drinking rat lines, such as the "HAD-1" lines are recognized animal models of alcoholism. The present work examined sex differences in alcohol consumption, object recognition, and exploratory behavior in male and female HAD-1 rats. Naïve male and female HAD-1 rats were tested in an object recognition test (ORT) prior to a chronic 24 h intermittent ethanol access procedure for five weeks. Object recognition parameters measured included exploratory behavior, object investigation, and time spent near objects. During the initial training trial, rearing, active object investigation and amount of time spent in the object-containing section was significantly greater in female HAD-1 rats compared to their male counterparts. During the subsequent testing trial, time spent in the object-containing section was greater in female, compared to male, rats; but active object investigation and rearing did not statistically differ between females and males. In addition, female HAD-1 rats consumed significantly more ethanol than their male counterparts, replicating previous findings. Moreover, across all animals there was a significant positive correlation between exploratory behavior in ORT and ethanol consumption level. These results indicate there are significant sex differences in cognitive performance and alcohol consumption in HAD-1 rats, which suggests neurobiological differences as well.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bbr.2019.112456" target="_blank" rel="noreferrer noopener">10.1016/j.bbr.2019.112456</a>
PMID: 31891743
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Alcohol use disorders
Attention
Behavioural brain research
Bell R L
Department of Pharmaceutical Sciences
Duvauchelle C L
Exploratory behavior
Fleming S M
January 2020 Update
Journal Article
Maddox W T
Martinez A
Mittal N
NEOMED College of Pharmacy
Novel object recognition
Object recognition test
Schallert T
Selectively bred high alcohol-drinking rats
Thakore N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0166-4328(99)00169-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-4328(99)00169-2</a>
Pages
167–175
Issue
2
Volume
109
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of brachium conjunctivum transection on a conditioned limb response in the cat.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-05
Subject
The topic of the resource
*Conditioning (Psychology); Animals; Cats; Cerebellar Nuclei/physiology; Cerebellum/injuries/pathology/*physiology; Memory/*physiology; Nerve Net/injuries/*physiology
Creator
An entity primarily responsible for making the resource
Voneida T J
Description
An account of the resource
Seven cats were trained to perform a forelimb conditioned response to a paired tone conditioned stimulus (CS)/shock unconditioned stimulus (UCS). Brachium conjunctivum section ipsilateral to the trained limb was carried out following criterion conditioned response (CR) performance. Lesion sites were identified histologically and further confirmed by observation of cellular changes in the dentate and interpositus nuclei ipsilateral to the section. The brachium conjunctivum was found to have been sectioned in four of the seven subjects. Each of these animals demonstrated a total or near-total loss of the CR. Extended postoperative training resulted in no increase in CR performance levels. The unconditioned response (UCR) remained unaffected, as did limb placing, accuracy of striking at moving objects, grooming, running and walking. The results are discussed in the context of an earlier report by McCormick et al. [Bull Psychonom Soc 1981;18:103-5], in which section of the superior cerebellar peduncle was found to abolish a conditioned nictitating membrane response in the rabbit. Taken together, they support the contention of Lavond [Annu Rev Psychol 1993;44:317-42], Thompson [In: Sprague JM, Epstein AN, editors. Progress in Psychobiology and Physiological Psychology. New York: Academic Press 1983, pp.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0166-4328(99)00169-2" target="_blank" rel="noreferrer noopener">10.1016/s0166-4328(99)00169-2</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Conditioning (Psychology)
2000
Animals
Behavioural brain research
Cats
Cerebellar Nuclei/physiology
Cerebellum/injuries/pathology/*physiology
Memory/*physiology
Nerve Net/injuries/*physiology
Voneida T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0166-4328(99)00069-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-4328(99)00069-8</a>
Pages
151–162
Issue
2
Volume
105
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of rubrospinal tractotomy on a conditioned limb response in the cat.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-11
Subject
The topic of the resource
Animal/physiology; Animals; Behavior; Cats; Conditioning; Forelimb/innervation/*physiology; Functional Laterality/physiology; Neural Pathways/anatomy & histology/physiology; Operant/*physiology; Red Nucleus/anatomy & histology/*physiology; Spinal Cord/anatomy & histology/*physiology; Stereotaxic Techniques
Creator
An entity primarily responsible for making the resource
Voneida T J
Description
An account of the resource
Five cats were trained to perform a forelimb conditioned response to a paired tone CS/shock UCS. Rubrospinal tract section ipsilateral to the trained limb was carried out following criterion CR performance. Lesion sites were identified histologically and further confirmed by observation of cellular changes in the red nucleus contralateral to the trained limb. Tractotomy resulted in total or near-total loss of the CR. Prolonged postoperative training resulted in no increase in CR performance levels. The UCR remained unaffected, as did limb placing, accuracy of striking at moving objects, grooming, running and walking. Training of the opposite limb in two subjects resulted in mean scores of 90 and 85% within three sessions. Control lesions in those subjects resulted in no changes in CR performance scores. The red nucleus receives a substantial input from sensorimotor cortex and cerebellum, both of which have been shown to represent essential parts of the brain circuitry involved in associative learning and memory. Since pyramidotomy has no effect on limb CR performance [Vonedia TJ. Exp Neurol 1976;19:483-493], the possible role of the red nucleus/rubrospinal tract is discussed in terms of a critical trigger area for the expression of a learned motor response.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0166-4328(99)00069-8" target="_blank" rel="noreferrer noopener">10.1016/s0166-4328(99)00069-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animal/physiology
Animals
Behavior
Behavioural brain research
Cats
Conditioning
Forelimb/innervation/*physiology
Functional Laterality/physiology
Neural Pathways/anatomy & histology/physiology
Operant/*physiology
Red Nucleus/anatomy & histology/*physiology
Spinal Cord/anatomy & histology/*physiology
Stereotaxic Techniques
Voneida T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0166-4328(96)02270-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-4328(96)02270-x</a>
Pages
139–148
Issue
2
Volume
87
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
Amygdala/*physiopathology; Animals; Association Learning/*physiology; Brain Mapping; Cerebral/*physiology; Classical/physiology; Cocaine-Related Disorders/*physiopathology; Conditioning; Dominance; Dopamine/physiology; Extinction; Male; Motivation; Psychological/physiology; Rats; Reinforcement Schedule; Self Administration; Sprague-Dawley; Substance Withdrawal Syndrome/*physiopathology
Creator
An entity primarily responsible for making the resource
Meil W M; See R E
Description
An account of the resource
This study investigated the ability of bilateral excitotoxic lesions of the basolateral amygdala (BLA) to disrupt cocaine self-administration, responding during extinction sessions, and stimulus cued recovery of extinguished responding in rats. BLA and sham lesions following 7 days of 3 h limited access cocaine self-administration sessions (0.33 mg/infusion) on a fixed ratio 1 (FR1) schedule of reinforcement failed to alter cocaine intake and responding on 7 subsequent days of self-administration. This lack of effect suggests that the BLA is not paramount for the maintenance of cocaine's reinforcing effects. In contrast, BLA lesions, but not sham lesions, following 7 to 14 days of cocaine self-administration attenuated responding on a lever associated with cocaine infusions on the first day of extinction sessions and blocked the ability of drug associated stimuli to reinstate extinguished responding following 20 daily extinction sessions. However, lesions of the BLA did not attenuate stimulus cued recovery of responding following 43 days of withdrawal. These results are consistent with the hypothesis that the BLA is important for the conditioned incentive properties of reinforcers, but not primary reinforcement itself.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0166-4328(96)02270-x" target="_blank" rel="noreferrer noopener">10.1016/s0166-4328(96)02270-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Amygdala/*physiopathology
Animals
Association Learning/*physiology
Behavioural brain research
Brain Mapping
Cerebral/*physiology
Classical/physiology
Cocaine-Related Disorders/*physiopathology
Conditioning
Dominance
Dopamine/physiology
Extinction
Male
Meil W M
Motivation
Psychological/physiology
Rats
Reinforcement Schedule
See R E
Self Administration
Sprague-Dawley
Substance Withdrawal Syndrome/*physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bbr.2018.01.029" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bbr.2018.01.029</a>
Pages
41–49
Volume
343
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-05
Subject
The topic of the resource
*Alpha-synuclein; *ATP13A2; *Mice; *Phenotype; *Sensorimotor; Adenosine Triphosphatases/*deficiency/genetics; alpha-Synuclein/genetics/*metabolism; Animal; Animals; Body Temperature; Body Weight; Disease Models; Female; Gait Disorders; Humans; Inbred C57BL; Male; Membrane Proteins/*deficiency/genetics; Mice; Motor Skills/physiology; Neurologic/*metabolism; Phenotype; Severity of Illness Index; Sex Characteristics; Transgenic
Creator
An entity primarily responsible for making the resource
Dirr Emily R; Ekhator Osunde R; Blackwood Rachel; Holden John G; Masliah Eliezer; Schultheis Patrick J; Fleming Sheila M
Description
An account of the resource
Loss of function mutations in the gene ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis, the former designated as an inherited form of Parkinson's disease (PD). The function of ATP13A2 is unclear but in vitro studies indicate it is a lysosomal protein and may interact with the presynaptic protein alpha-synuclein (aSyn) and certain heavy metals. Accumulation of aSyn is a major component of lewy bodies, the pathological hallmark of PD. Atp13a2-deficient (13a2) mice develop age-dependent sensorimotor deficits, and accumulation of insoluble aSyn in the brain. To better understand the interaction between ATP13A2 and aSyn, double mutant mice with loss of Atp13a2 function combined with overexpression of human wildtype aSyn were generated. Female and male wildtype (WT), 13a2, aSyn, and 13a2-aSyn mice were tested on a battery of sensorimotor tests including adhesive removal, challenging beam traversal, spontaneous activity, gait, locomotor activity, and nest-building at 2, 4, and 6 months of age. Double mutant mice showed an earlier onset and accelerated alterations in sensorimotor function that were age, sex and test-dependent. Female 13a2-aSyn mice showed early and progressive dysfunction on the beam and in locomotor activity. In males, 13a2-aSyn mice showed more severe impairments in spontaneous activity and adhesive removal. Sex differences were also observed in aSyn and 13a2-aSyn mice on the beam, cylinder, and adhesive removal tests. In other tasks, double mutant mice displayed deficits similar to aSyn mice. These results indicate loss of Atp13a2 function exacerbates the sensorimotor phenotype in aSyn mice in an age and sex-dependent manner.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bbr.2018.01.029" target="_blank" rel="noreferrer noopener">10.1016/j.bbr.2018.01.029</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alpha-synuclein
*ATP13A2
*Mice
*Phenotype
*Sensorimotor
2018
Adenosine Triphosphatases/*deficiency/genetics
alpha-Synuclein/genetics/*metabolism
Animal
Animals
Behavioural brain research
Blackwood Rachel
Body Temperature
Body Weight
Department of Pharmaceutical Sciences
Dirr Emily R
Disease Models
Ekhator Osunde R
Female
Fleming Sheila M
Gait Disorders
Holden John G
Humans
Inbred C57BL
Male
Masliah Eliezer
Membrane Proteins/*deficiency/genetics
Mice
Motor Skills/physiology
NEOMED College of Pharmacy
Neurologic/*metabolism
Phenotype
Schultheis Patrick J
Severity of Illness Index
Sex Characteristics
Transgenic
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0166-4328(95)00167-0</a>
Pages
199–205
Issue
1
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-01
Subject
The topic of the resource
Amphetamines/pharmacology; Animals; Antipsychotic Agents/*pharmacology; Cholinergic Agents/pharmacology; Clozapine/pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dopamine D1/*antagonists & inhibitors; Dose-Response Relationship; Drug; Generalization; Male; Rats; Receptors; Response/drug effects; Serotonin Agents/pharmacology; Serotonin Receptor Agonists/pharmacology; Sprague-Dawley; Thiazepines/*pharmacology
Creator
An entity primarily responsible for making the resource
Meehan S M; Schechter M D
Description
An account of the resource
CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated, two-choice, operant task to discriminate 20.0 mg/kg CGS 10746B from its vehicle. CGS 10746B was highly discriminable, producing rapid acquisition of the discrimination, and its effects were dose-responsive allowing generation of an ED50 value of 6.16 mg/kg. Substitution tests were conducted with other typical and atypical antipsychotic compounds: haloperidol, chlorpromazine, clozapine and SCH 23390. Additional tests examined generalization from the CGS 10746B stimulus properties to the calcium channel blocker isradipine, as well as to the anticholinergics atropine, scopolamine and methylscopolamine, as well as to the serotonergic agonist DOI. Clozapine and SCH 23390 were the only substances to substitute for the CGS 10746B stimulus cue. Results are discussed in terms of potential D1 receptor selectivity of CGS 10746B.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">10.1016/0166-4328(95)00167-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Amphetamines/pharmacology
Animals
Antipsychotic Agents/*pharmacology
Behavioural brain research
Cholinergic Agents/pharmacology
Clozapine/pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dopamine D1/*antagonists & inhibitors
Dose-Response Relationship
Drug
Generalization
Male
Meehan S M
Rats
Receptors
Response/drug effects
Schechter M D
Serotonin Agents/pharmacology
Serotonin Receptor Agonists/pharmacology
Sprague-Dawley
Thiazepines/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0166-4328(94)90011-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0166-4328(94)90011-6</a>
Pages
87–90
Issue
1
Volume
61
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age related changes of social memory/recognition in male Fischer 344 rats.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-03
Subject
The topic of the resource
*Social Behavior; Aging/*physiology; Animal/physiology; Animals; Arousal/physiology; Female; Habituation; Inbred F344; Male; Mental Recall/*physiology; Psychophysiologic/*physiology; Psychophysiology; Rats; Retention (Psychology)/physiology; Sexual Behavior; Social Environment
Creator
An entity primarily responsible for making the resource
Guan X; Dluzen D E
Description
An account of the resource
Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. For test 1, males received three 2-min exposures to the same stimulus ovariectomized female, followed by three 2-min exposures to a different stimulus female with an inter-trial interval of 6 min. All groups showed a habituation response with investigation times decreasing on trials 2 and 3. Introduction of a different stimulus female on trial 4 (dishabituation) resulted in significant differences with investigation times of the 3-month animals being significantly greater than both the 15- and 22-month animals and those of the 15- being greater than the 22-month animals. Notably, the 22-month-old animals failed to dishabituate on this task. For test 2, all animals received two trials with different stimulus females used in each trial. While investigation times of the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0166-4328(94)90011-6" target="_blank" rel="noreferrer noopener">10.1016/0166-4328(94)90011-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
1994
Aging/*physiology
Animal/physiology
Animals
Arousal/physiology
Behavioural brain research
Dluzen D E
Female
Guan X
Habituation
Inbred F344
Male
Mental Recall/*physiology
Psychophysiologic/*physiology
Psychophysiology
Rats
Retention (Psychology)/physiology
Sexual Behavior
Social Environment