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40
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Text
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URL Address
<a href="http://doi.org/10.14740/cr560w" target="_blank" rel="noreferrer noopener">http://doi.org/10.14740/cr560w</a>
Pages
105–110
Issue
3
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of Clopidogrel With Prasugrel and Ticagrelor in Patients With Acute Coronary Syndrome: Clinical Outcomes From the National Cardiovascular Database ACTION Registry.
Publisher
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Cardiology research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-06
Subject
The topic of the resource
Antiplatelet therapy; Coronary artery disease; Health care outcomes
Creator
An entity primarily responsible for making the resource
Khayata Mohamed; Gabra Joseph N; Nasser M Farhan; Litman George I; Bhakta Shyam; Raina Rupesh
Description
An account of the resource
BACKGROUND: We aimed to compare the clinical outcomes of clopidogrel, prasugrel, and ticagrelor in clinical practice using the National Cardiovascular Database ACTION Registry((R)). Treatment guidelines for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention recommend dual antiplatelet therapy (DAPT) for 12 months. Few clinical trials have compared the safety and efficacy of clopidogrel with that of newer antiplatelet therapies. METHODS: A retrospective study of patients hospitalized for ACS at Cleveland Clinic Akron General was conducted. Data elements included detailed medical history and clinical outcomes during hospital stay. The primary outcome was a composite of major clinical events (cardiogenic shock, atrial fibrillation, ventricular fibrillation, ventricular tachycardia, heart failure, bleeding, and mechanical ventilation). The independent variable was the type of DAPT. Statistical analyses were performed using Chi-square and Mann-Whitney U tests. A post-hoc analysis was performed to compare between the antiplatelet drugs head-to-head. RESULTS: Subjects (n = 1,388) admitted between January 2011 and March 2016 with ACS and treated with clopidogrel, prasugrel, or ticagrelor were included in the study. Mean age was 65 +/- 14 years and 46% had ST-segment elevation myocardial infarction. Prasugrel administration within 24 h was associated with a lower incidence of the composite outcome (P = 0.049), bleeding (P = 0.028), and heart failure (P = 0.002). CONCLUSION: There was a significant difference between the type of antiplatelet drug and clinical outcomes in ACS patients who were treated with DAPT. Observations from current study may provide important information for prescribers in clinical decision-making.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.14740/cr560w" target="_blank" rel="noreferrer noopener">10.14740/cr560w</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Antiplatelet therapy
Bhakta Shyam
Cardiology research
Coronary Artery Disease
Department of Internal Medicine
Gabra Joseph N
Health care outcomes
Khayata Mohamed
Litman George I
Nasser M Farhan
NEOMED College of Medicine
Raina Rupesh
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jacc.2015.07.037" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jacc.2015.07.037</a>
Pages
1378–1391
Issue
12
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cardiovascular Effects of Exposure to Cigarette Smoke and Electronic Cigarettes: Clinical Perspectives From the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology.
Publisher
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Journal of the American College of Cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-09
Subject
The topic of the resource
atherogenesis; Cardiovascular Diseases – Etiology; Cardiovascular Diseases/*etiology; Electronic Cigarettes – Adverse Effects; Electronic Nicotine Delivery Systems/*adverse effects; Epigenesis; Genes; Genetic; genetic and epigenetic effects; Humans; Impact of Events Scale; Scales; smoke-free legislation; Smoking – Complications; Smoking – Legislation and Jurisprudence – United States; Smoking Cessation; Smoking/*adverse effects/legislation & jurisprudence; thrombosis; tobacco cessation; United States
Creator
An entity primarily responsible for making the resource
Morris Pamela B; Ference Brian A; Jahangir Eiman; Feldman Dmitriy N; Ryan John J; Bahrami Hossein; El-Chami Mikhael F; Bhakta Shyam; Winchester David E; Al-Mallah Mouaz H; Sanchez Shields Monica; Deedwania Prakash; Mehta Laxmi S; Phan Binh An P; Benowitz Neal L
Description
An account of the resource
Cardiovascular morbidity and mortality as a result of inhaled tobacco products continues to be a global healthcare crisis, particularly in low- and middle-income nations lacking the infrastructure to develop and implement effective public health policies limiting tobacco use. Following initiation of public awareness campaigns 50 years ago in the United States, considerable success has been achieved in reducing the prevalence of cigarette smoking and exposure to secondhand smoke. However, there has been a slowing of cessation rates in the United States during recent years, possibly caused by high residual addiction or fatigue from cessation messaging. Furthermore, tobacco products have continued to evolve faster than the scientific understanding of their biological effects. This review considers selected updates on the genetics and epigenetics of smoking behavior and associated cardiovascular risk, mechanisms of atherogenesis and thrombosis, clinical effects of smoking and benefits of cessation, and potential impact of electronic cigarettes on cardiovascular health.
Identifier
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<a href="http://doi.org/10.1016/j.jacc.2015.07.037" target="_blank" rel="noreferrer noopener">10.1016/j.jacc.2015.07.037</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Al-Mallah Mouaz H
atherogenesis
Bahrami Hossein
Benowitz Neal L
Bhakta Shyam
Cardiovascular Diseases – Etiology
Cardiovascular Diseases/*etiology
Deedwania Prakash
Department of Internal Medicine
El-Chami Mikhael F
Electronic Cigarettes – Adverse Effects
Electronic Nicotine Delivery Systems/*adverse effects
Epigenesis
Feldman Dmitriy N
Ference Brian A
Genes
Genetic
genetic and epigenetic effects
Humans
Impact of Events Scale
Jahangir Eiman
Journal of the American College of Cardiology
Mehta Laxmi S
Morris Pamela B
NEOMED College of Medicine
Phan Binh An P
Ryan John J
Sanchez Shields Monica
Scales
smoke-free legislation
Smoking – Complications
Smoking – Legislation and Jurisprudence – United States
Smoking Cessation
Smoking/*adverse effects/legislation & jurisprudence
Thrombosis
tobacco cessation
United States
Winchester David E