1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2004.12.013</a> Pages 188–195 Issue 2 Volume 1035 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Dopamine transporter function differences between male and female CD-1 mice. Publisher An entity responsible for making the resource available Brain research Date A point or period of time associated with an event in the lifecycle of the resource 2005 2005-02 Subject The topic of the resource *Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/physiology; Dopamine Plasma Membrane Transport Proteins; Dopamine/physiology; Female; Male; Membrane Glycoproteins/*physiology; Membrane Transport Proteins/*physiology; Mice; Nerve Tissue Proteins/*physiology Creator An entity primarily responsible for making the resource Bhatt Sandeep D; Dluzen Dean E Description An account of the resource It has been reported that male mice are more susceptible to the neurotoxic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system. Since MA utilizes the dopamine transporter (DAT) to exert its effects, in the present study, we tested for differences in the dynamics of DAT function between male and female mice as an approach to understand some of the bases for this sex difference in MA-induced NSDA neurotoxicity. To accomplish this goal, in Experiment 1, the amount of dopamine (DA) obtained following DA infusion into the superfused striatal tissue fragments of male and female mice was measured while in Experiment 2 responses to the DA uptake blocker, nomifensine (NMF), were assessed in these preparations. The differences obtained to these treatments demonstrate that marked differences in DA transporter activity exist between male and female mice. When combining the DA and DOPAC measures from these two experiments, the data suggest that the female mice show a more active and efficient recovery and vesicular packaging of extracellular DA. These findings have important implications for sex differences in NSDA functions and responses to neurotoxins which enter the neurons via the DAT. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2004.12.013</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Sex Characteristics 2005 3 4-Dihydroxyphenylacetic Acid/metabolism Animals Bhatt Sandeep D Brain research Corpus Striatum/physiology Dluzen Dean E Dopamine Plasma Membrane Transport Proteins Dopamine/physiology Female Male Membrane Glycoproteins/*physiology Membrane Transport Proteins/*physiology Mice Nerve Tissue Proteins/*physiology