1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/S2095-4964(16)60247-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/S2095-4964(16)60247-9</a>
Pages
84–99
Issue
2
Volume
14
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Health-promoting and disease-preventive potential of Trianthema portulacastrum Linn. (Gadabani) -An Indian medicinal and dietary plant.
Publisher
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Journal of integrative medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-03
Subject
The topic of the resource
*Aizoaceae/chemistry; *Plants; Edible; Health Promotion; Humans; India; Medicinal; Nutritive Value; Plant Extracts/pharmacology/toxicity
Creator
An entity primarily responsible for making the resource
Yamaki Jason; Nagulapalli Venkata Kalyan C; Mandal Animesh; Bhattacharyya Piyali; Bishayee Anupam
Description
An account of the resource
It is estimated that 80% of the world population depends on traditional medicine for primary healthcare need. Trianthema portulacastrum Linn. (family: Aizoaceae) is a small perennial weed found in the Americas, Africa, India, and other regions of the world. This plant is used extensively in Indian traditional medicines and is also consumed as a vegetable throughout Asia for its perceived health benefits. Phytochemical analysis of T. portulacastrum reveals the presence of alkaloids, flavonoids, terpenoids, saponins, and phenolic compounds. Emerging studies demonstrate that crude extracts as well as bioactive phytoconstituents of T. portulacastrum exhibit potent antioxidant, anti-infective, analgesic, and anti-inflammatory activities. A growing number of in vitro and in vivo studies demonstrate various biological and pharmacological activities, including prevention and amelioration of hepatotoxicity, nephrotoxicity, hyperglycemia, hyperlipidemia, infectious diseases and cancer. This review aims to present and analyze available literature to understand the full potential of T. portulacastrum in health promotion and disease prevention. Current limitations and future directions of research on this medicinal and dietary plant are also critically discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/S2095-4964(16)60247-9" target="_blank" rel="noreferrer noopener">10.1016/S2095-4964(16)60247-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aizoaceae/chemistry
*Plants
2016
Bhattacharyya Piyali
Bishayee Anupam
Edible
Health Promotion
Humans
India
Journal of integrative medicine
Mandal Animesh
Medicinal
Nagulapalli Venkata Kalyan C
Nutritive Value
Plant Extracts/pharmacology/toxicity
Yamaki Jason
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/01635581.2016.1115094</a>
Pages
120–130
Issue
1
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Publisher
An entity responsible for making the resource available
Nutrition and cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
1905-07
Subject
The topic of the resource
*Punicaceae/chemistry; 10-Dimethyl-1; 2-benzanthracene; 9; Animal Studies; Animals; Anticarcinogenic Agents/*therapeutic use; Apoptosis; Apoptosis/*drug effects; Breast Neoplasms – Mortality; Breast Neoplasms – Prevention and Control; Breast Neoplasms – Risk Factors; Cell Physiology; Cell Proliferation/*drug effects; Diet – Evaluation; Experimental/pathology/*prevention & control; Female; Funding Source; Gene Expression Regulation; Genes; Human; Immunohistochemistry; Mammary Neoplasms; Mutation; National Institutes of Health (U.S.); Neoplasms – Prevention and Control; Phytotherapy; Pomegranate; Proto-Oncogene Proteins c-bcl-2/analysis; Rats; Sprague-Dawley; Tamoxifen; United States
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Mandal Animesh; Bhattacharyya Piyali; Bhatia Deepak
Description
An account of the resource
Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of its various health benefits. This study was initiated to investigate chemopreventive potential of a pomegranate emulsion (PE) against 7,12-dimethylbenz(a)anthracene (DMBA) rat mammary carcinogenesis. The animals were orally administered with PE (0.2-5.0 g/kg), starting 2 wk before and 16 wk following DMBA treatment. PE exhibited a striking reduction of DMBA-induced mammary tumor incidence, total tumor burden, and reversed histopathological changes. PE dose-dependently suppressed cell proliferation and induced apoptosis in mammary tumors. Immunohistochemical studies showed that PE increased intratumor Bax, decreased Bcl2 and manifested a proapoptotic shift in Bax/Bcl2 ratio. In addition, our gene expression study showed PE-mediated upregulation of Bad, caspase-3, caspase-7, caspase-9, poly (ADP ribose) polymerase and cytochrome c in mammary tumors. Thus, PE exerts chemoprevention of mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis mediated through upregulation of Bax and downregulation of Bcl2 in concert with caspase cascades. Pomegranate bioactive phytoconstituents could be developed as a chemopreventive drug to reduce the risk of breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/01635581.2016.1115094" target="_blank" rel="noreferrer noopener">10.1080/01635581.2016.1115094</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Punicaceae/chemistry
10-Dimethyl-1
2-benzanthracene
2016
9
Animal Studies
Animals
Anticarcinogenic Agents/*therapeutic use
Apoptosis
Apoptosis/*drug effects
Bhatia Deepak
Bhattacharyya Piyali
Bishayee Anupam
Breast Neoplasms – Mortality
Breast Neoplasms – Prevention and Control
Breast Neoplasms – Risk Factors
Cell Physiology
Cell Proliferation/*drug effects
Diet – Evaluation
Experimental/pathology/*prevention & control
Female
Funding Source
Gene Expression Regulation
Genes
Human
Immunohistochemistry
Mammary Neoplasms
Mandal Animesh
Mutation
National Institutes of Health (U.S.)
Neoplasms – Prevention and Control
Nutrition and cancer
Phytotherapy
Pomegranate
Proto-Oncogene Proteins c-bcl-2/analysis
Rats
Sprague-Dawley
Tamoxifen
United States