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Text
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URL Address
<a href="http://doi.org/10.1152/ajpgi.00417.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpgi.00417.2002</a>
Pages
G349–356
Issue
3
Volume
284
Dublin Core
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Title
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Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.
Publisher
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American journal of physiology. Gastrointestinal and liver physiology
Date
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2003
2003-03
Subject
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Animals; Bile Acids and Salts/biosynthesis/genetics/*physiology; Bile/*physiology; Cardiovascular Diseases/genetics/physiopathology; Cholesterol/physiology; Cytoplasmic and Nuclear/*physiology; Feedback/physiology; Gene Expression Regulation/physiology; Humans; Liver Diseases/genetics/physiopathology; Liver/*physiology; Receptors
Creator
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Chiang John Y L
Description
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Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Recent studies reveal that bile acids also are signaling molecules that activate several nuclear receptors and regulate many physiological pathways and processes to maintain bile acid and cholesterol homeostasis. Mutations of the principal regulatory genes in bile acid biosynthetic pathways have recently been identified in human patients with hepatobiliary and cardiovascular diseases. Genetic manipulation of key regulatory genes and bile acid receptor genes in mice have been obtained. These advances have greatly improved our understanding of the molecular mechanisms underlying complex liver physiology but also raise many questions and controversies to be resolved. These developments will lead to early diagnosis and discovery of drugs for treatment of liver and cardiovascular diseases.
Identifier
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<a href="http://doi.org/10.1152/ajpgi.00417.2002" target="_blank" rel="noreferrer noopener">10.1152/ajpgi.00417.2002</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
American journal of physiology. Gastrointestinal and liver physiology
Animals
Bile Acids and Salts/biosynthesis/genetics/*physiology
Bile/*physiology
Cardiovascular Diseases/genetics/physiopathology
Chiang John Y L
Cholesterol/physiology
Cytoplasmic and Nuclear/*physiology
Department of Integrative Medical Sciences
Feedback/physiology
Gene Expression Regulation/physiology
Humans
Liver Diseases/genetics/physiopathology
Liver/*physiology
NEOMED College of Medicine
Receptors