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Text
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URL Address
<a href="http://doi.org/10.1002/cphy.c120023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cphy.c120023</a>
Pages
1191–1212
Issue
3
Volume
3
Dublin Core
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Title
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Bile acid metabolism and signaling.
Publisher
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Comprehensive Physiology
Date
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2013
2013-07
Subject
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Animals; Bile Acids and Salts/*metabolism/therapeutic use; Biliary Tract Diseases/metabolism; Cholesterol/metabolism; Cytoplasmic and Nuclear/metabolism; Enterohepatic Circulation/physiology; Feedback; G-Protein-Coupled/metabolism; Homeostasis/physiology; Humans; Inflammation/metabolism; Liver/metabolism; Physiological/physiology; Receptors; Signal Transduction/*physiology
Creator
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Chiang John Y L
Description
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Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling molecules and metabolic regulators that activate nuclear receptors and G protein-coupled receptor (GPCR) signaling to regulate hepatic lipid, glucose, and energy homeostasis and maintain metabolic homeostasis. Conversion of cholesterol to bile acids is critical for maintaining cholesterol homeostasis and preventing accumulation of cholesterol, triglycerides, and toxic metabolites, and injury in the liver and other organs. Enterohepatic circulation of bile acids from the liver to intestine and back to the liver plays a central role in nutrient absorption and distribution, and metabolic regulation and homeostasis. This physiological process is regulated by a complex membrane transport system in the liver and intestine regulated by nuclear receptors. Toxic bile acids may cause inflammation, apoptosis, and cell death. On the other hand, bile acid-activated nuclear and GPCR signaling protects against inflammation in liver, intestine, and macrophages. Disorders in bile acid metabolism cause cholestatic liver diseases, dyslipidemia, fatty liver diseases, cardiovascular diseases, and diabetes. Bile acids, bile acid derivatives, and bile acid sequestrants are therapeutic agents for treating chronic liver diseases, obesity, and diabetes in humans.
Identifier
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<a href="http://doi.org/10.1002/cphy.c120023" target="_blank" rel="noreferrer noopener">10.1002/cphy.c120023</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Animals
Bile Acids and Salts/*metabolism/therapeutic use
Biliary Tract Diseases/metabolism
Chiang John Y L
Cholesterol/metabolism
Comprehensive Physiology
Cytoplasmic and Nuclear/metabolism
Department of Integrative Medical Sciences
Enterohepatic Circulation/physiology
Feedback
G-Protein-Coupled/metabolism
Homeostasis/physiology
Humans
Inflammation/metabolism
Liver/metabolism
NEOMED College of Medicine
Physiological/physiology
Receptors
Signal Transduction/*physiology