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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2014/502093" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2014/502093</a>
Pages
502093–502093
Volume
2014
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-beta and IGF signaling.
Publisher
An entity responsible for making the resource available
BioMed research international
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
Androgens/metabolism; Animals; Disease Progression; Epithelial Cells/cytology; Estrogen/metabolism; Estrogens/metabolism; Humans; Male; Mice; Prostate/metabolism; Prostatic Neoplasms/*metabolism; Receptors; Signal Transduction; Somatomedins/*metabolism; Stromal Cells/*cytology; Transforming Growth Factor beta/*metabolism
Creator
An entity primarily responsible for making the resource
Lee Chung; Jia Zhenyu; Rahmatpanah Farah; Zhang Qiang; Zi Xiaolin; McClelland Michael; Mercola Dan
Description
An account of the resource
This review postulates the role of transforming growth factor-beta (TGF-beta) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2014/502093" target="_blank" rel="noreferrer noopener">10.1155/2014/502093</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Androgens/metabolism
Animals
BioMed research international
Disease Progression
Epithelial Cells/cytology
Estrogen/metabolism
Estrogens/metabolism
Humans
Jia Zhenyu
Lee Chung
Male
McClelland Michael
Mercola Dan
Mice
Prostate/metabolism
Prostatic Neoplasms/*metabolism
Rahmatpanah Farah
Receptors
Signal Transduction
Somatomedins/*metabolism
Stromal Cells/*cytology
Transforming Growth Factor beta/*metabolism
Zhang Qiang
Zi Xiaolin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2015/285983" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2015/285983</a>
Pages
285983–285983
Volume
2015
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Predictors of mortality for nursing home-acquired pneumonia: a systematic review.
Publisher
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BioMed research international
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
1905-07
Subject
The topic of the resource
80 and over; Aged; Bacterial/*diagnosis/*mortality/therapy; Biological Markers – Therapeutic Use; CINAHL Database; Cross Infection/*diagnosis/*mortality/therapy; Embase; Female; Homes for the Aged/statistics & numerical data; Human; Humans; Incidence; Male; Medline; Meta Analysis; Mortality – Risk Factors; Nursing Care/*statistics & numerical data; Nursing Home Patients; Nursing Homes/*statistics & numerical data; Pneumonia; Pneumonia – Risk Factors; Prognosis; Risk Assessment/methods; Severity of Illness Index; Survival Analysis; Systematic Review; Treatment Outcome
Creator
An entity primarily responsible for making the resource
Dhawan Naveen; Pandya Naushira; Khalili Michael; Bautista Manuel; Duggal Anurag; Bahl Jaya; Gupta Vineet
Description
An account of the resource
BACKGROUND: Current risk stratification tools, primarily used for CAP, are suboptimal in predicting nursing home acquired pneumonia (NHAP) outcome and mortality. We conducted a systematic review to evaluate current evidence on the usefulness of proposed predictors of NHAP mortality. METHODS: PubMed (MEDLINE), EMBASE, and CINAHL databases were searched for articles published in English between January 1978 and January 2014. The literature search elicited a total of 666 references; 580 were excluded and 20 articles met the inclusion criteria for the final analysis. RESULTS: More studies supported the Pneumonia Severity Index (PSI) as a superior predictor of NHAP severity. Fewer studies suggested CURB-65 and SOAR (especially for the need of ICU care) as useful predictors for NHAP mortality. There is weak evidence for biomarkers like C-reactive protein and copeptin as prognostic tools. CONCLUSION: The evidence supports the use of PSI as the best available indicator while CURB-65 may be an alternative prognostic indicator for NHAP mortality. Overall, due to the paucity of information, biomarkers may not be as effective in this role. Larger prospective studies are needed to establish the most effective predictor(s) or combination scheme to help clinicians in decision-making related to NHAP mortality.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2015/285983" target="_blank" rel="noreferrer noopener">10.1155/2015/285983</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
80 and over
Aged
Bacterial/*diagnosis/*mortality/therapy
Bahl Jaya
Bautista Manuel
Biological Markers – Therapeutic Use
BioMed research international
CINAHL Database
Cross Infection/*diagnosis/*mortality/therapy
Department of Internal Medicine
Dhawan Naveen
Duggal Anurag
Embase
Female
Gupta Vineet
Homes for the Aged/statistics & numerical data
Human
Humans
Incidence
Khalili Michael
Male
Medline
Meta Analysis
Mortality – Risk Factors
NEOMED College of Medicine
Nursing Care/*statistics & numerical data
Nursing Home Patients
Nursing Homes/*statistics & numerical data
Pandya Naushira
Pneumonia
Pneumonia – Risk Factors
Prognosis
Risk Assessment/methods
Severity of Illness Index
Survival Analysis
systematic review
Treatment Outcome
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2014/670842" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2014/670842</a>
Pages
670842–670842
Volume
2014
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Molecular, phenotypic aspects and therapeutic horizons of rare genetic bone disorders.
Publisher
An entity responsible for making the resource available
BioMed research international
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
Bone and Bones/*physiopathology; Bone Diseases/*epidemiology/genetics; Humans; Osteogenesis/genetics; Rare Diseases/*epidemiology/genetics
Creator
An entity primarily responsible for making the resource
Faruqi Taha; Dhawan Naveen; Bahl Jaya; Gupta Vineet; Vohra Shivani; Tu Khin; Abdelmagid Samir M
Description
An account of the resource
A rare disease afflicts less than 200,000 individuals, according to the National Organization for Rare Diseases (NORD) of the United States. Over 6,000 rare disorders affect approximately 1 in 10 Americans. Rare genetic bone disorders remain the major causes of disability in US patients. These rare bone disorders also represent a therapeutic challenge for clinicians, due to lack of understanding of underlying mechanisms. This systematic review explored current literature on therapeutic directions for the following rare genetic bone disorders: fibrous dysplasia, Gorham-Stout syndrome, fibrodysplasia ossificans progressiva, melorheostosis, multiple hereditary exostosis, osteogenesis imperfecta, craniometaphyseal dysplasia, achondroplasia, and hypophosphatasia. The disease mechanisms of Gorham-Stout disease, melorheostosis, and multiple hereditary exostosis are not fully elucidated. Inhibitors of the ACVR1/ALK2 pathway may serve as possible therapeutic intervention for FOP. The use of bisphosphonates and IL-6 inhibitors has been explored to be useful in the treatment of fibrous dysplasia, but more research is warranted. Cell therapy, bisphosphonate polytherapy, and human growth hormone may avert the pathology in osteogenesis imperfecta, but further studies are needed. There are still no current effective treatments for these bone disorders; however, significant promising advances in therapeutic modalities were developed that will limit patient suffering and treat their skeletal disabilities.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2014/670842" target="_blank" rel="noreferrer noopener">10.1155/2014/670842</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Abdelmagid Samir M
Bahl Jaya
BioMed research international
Bone and Bones/*physiopathology
Bone Diseases/*epidemiology/genetics
Dhawan Naveen
Faruqi Taha
Gupta Vineet
Humans
Osteogenesis/genetics
Rare Diseases/*epidemiology/genetics
Tu Khin
Vohra Shivani