1
40
505
-
Text
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URL Address
<a href="http://doi.org/10.2741/1572" target="_blank" rel="noreferrer noopener">http://doi.org/10.2741/1572</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
790-798
Volume
10
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Title
A name given to the resource
The LEAPS approach to vaccine development
Publisher
An entity responsible for making the resource available
Frontiers in Bioscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
beta-2-microglobulin; binding-site; Biochemistry & Molecular Biology; Cell Biology; class-ii molecules; dc; dendritic cells; flt3 ligand fl; herpes simplex virus; HIV; human; immune responses; in-vivo; LEAPS constructs; major histocompatibility complex; peptide; protection; review; t-lymphocytes; th1 immune-responses; vaccines
Creator
An entity primarily responsible for making the resource
Zimmerman D H; Rosenthal K S
Description
An account of the resource
The Ligand Epitope Antigen Presentation System ( L. E. A. P. S. TM) approach to vaccine development utilizes immune peptides to promote the immunogenicity and influence the type of immune response generated towards epitopes in peptides which may be too small to elicit an immune response. The covalent attachment of these immune peptides to the antigenic peptide promotes the interaction of the epitope with T cells ( T cell binding ligand (TCBL)) or antigen presenting cells ( immune cell binding ligand (ICBL)) and ultimately promotes binding with the T cell receptor on CD4 or CD8 T cells. The "J" ICBL/TCBL peptide derived from the beta-2-microglobulin chain of MHC I molecules promotes Th1 type responses to the antigenic peptide while the "G" ICBL/TCBL peptide derived from the beta chain of MHC II molecules promotes Th2 types of responses. The efficacy of this approach has been demonstrated by characterization of the immune responses to L. E. A. P. S. vaccines and by elicitation of protection from infectious challenge with herpes simplex virus and other pathogens. The protection studies show that the L. E. A. P. S. approach allows customization of the immune response appropriate for inducing protection from disease. The theory, background, examples and studies of the mechanism of action of the L. E. A. P. S. vaccines will be discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2741/1572" target="_blank" rel="noreferrer noopener">10.2741/1572</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
beta-2-microglobulin
binding-site
Biochemistry & Molecular Biology
Cell Biology
class-ii molecules
dc
dendritic cells
flt3 ligand fl
Frontiers in Bioscience
herpes simplex virus
HIV
Human
immune responses
in-vivo
Journal Article
LEAPS constructs
major histocompatibility complex
peptide
protection
review
Rosenthal K S
T-Lymphocytes
th1 immune-responses
Vaccines
Zimmerman D H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
281-286
Issue
3
Volume
42
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Dublin Core
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Title
A name given to the resource
Synthesis of 3 beta-(4- I-125 Iodophenyl)tropane-2 beta-pyrrolidine carboxamide ( I-125 RTI-229)
Publisher
An entity responsible for making the resource available
Journal of Labelled Compounds & Radiopharmaceuticals
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-03
Subject
The topic of the resource
acid isopropyl ester; analogs; Biochemistry & Molecular Biology; brain; Chemistry; chloramine-T; cocaine; dopamine transporter; high-affinity; iodine-125 labelling; iododestannylation; ligand; nonhuman primates; Pharmacology & Pharmacy; radioiodination; RTI-229
Creator
An entity primarily responsible for making the resource
Zhong D S; Kotian P; Wyrick C D; Seltzman H H; Kepler J A; Boja J W; Kuhar M J; Carroll F I
Description
An account of the resource
A WIN 35,055-2 analog, 3 beta-(4-iodophenyl)tropane-2 beta-pyrrolidine carboxamide (RTI-229), has been radiolabelled with iodine-125 by radioiododestannylation of the corresponding trimethyltin derivative using carrier-free sodium iodide-125 as the isotope source. Purification by reversed-phase HPLC gives [I-125]RTI-229 in good yield (89.4%) with high radiochemical purity (>99%) and high specific activity (2125 mCi/mu mol, 78.6 GBq/mu mol, based on the specific activity of the (NaI)-I-125 used).
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1999
acid isopropyl ester
analogs
Biochemistry & Molecular Biology
Boja J W
Brain
Carroll F I
Chemistry
chloramine-T
Cocaine
Dopamine transporter
high-affinity
iodine-125 labelling
iododestannylation
Journal Article
Journal of Labelled Compounds & Radiopharmaceuticals
Kepler J A
Kotian P
Kuhar M J
ligand
nonhuman primates
Pharmacology & Pharmacy
radioiodination
RTI-229
Seltzman H H
Wyrick C D
Zhong D S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1432-A1432
Issue
8
Volume
14
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Title
A name given to the resource
DNA elements important in the promoter activity and regulation of CYP4F2 leukotriene B4 omega-hydroxylase gene
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-05
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Zhang X; Hardwick J P
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2000
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Hardwick J P
Journal Article
Life Sciences & Biomedicine - Other
Topics
Zhang X
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1462-A1462
Issue
7
Volume
13
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Title
A name given to the resource
Proximal promoter structure and transcriptional regulation of the CYP4F2 human liver leukotriene B-4 omega-hydroxylase gene
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Zhang X; Chen L; Hardwick J P
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1999
Biochemistry & Molecular Biology
Cell Biology
Chen L
Faseb Journal
Hardwick J P
Journal Article
Life Sciences & Biomedicine - Other
Topics
Zhang X
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A147-A147
Issue
4
Volume
16
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Title
A name given to the resource
Transcriptional regulation of the CYP4F2 gene by cytokines
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Zhang X L; Jahan A; Malmer M; Nguyen D; Hardwick J P
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Hardwick J P
Jahan A
Journal Article
Life Sciences & Biomedicine - Other
Malmer M
Nguyen D
Topics
Zhang X L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1433-A1433
Issue
8
Volume
14
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Title
A name given to the resource
DNA elements important in the promoter activity and regulation of CYP4F2 leukotriene B-4 omega-hydroxylase gene
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-05
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Zhang X L; Hardwick J P
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2000
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Hardwick J P
Journal Article
Life Sciences & Biomedicine - Other
Topics
Zhang X L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A460-A460
Issue
4
Volume
20
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Title
A name given to the resource
Repression of CYP4F1 gene by peroxisome proliferators is mediated by HNF4 alpha and PPAR alpha competition for PPRE sites in the CYP4F1 promoter
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Zhang X L; Donelson E; Goswami P; Song B J; Hardwick J P
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An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
Biochemistry & Molecular Biology
Cell Biology
Donelson E
Faseb Journal
Goswami P
Hardwick J P
Journal Article
Life Sciences & Biomedicine - Other
Song B J
Topics
Zhang X L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A182-A182
Issue
4
Volume
15
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Title
A name given to the resource
Transcriptional regulation of human 12 alpha-hydroxylase gene (CYP8B1) by bile acids and nuclear receptors
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Zhang M; Chiang J Y L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
Biochemistry & Molecular Biology
Cell Biology
Chiang J Y L
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Zhang M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1431-A1431
Issue
8
Volume
14
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Title
A name given to the resource
Characterization of human 12 alpha-hydroxylase gene (CYP8B1) promoter and regulation by bile acids
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-05
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Zhang M; Chiang J Y L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2000
Biochemistry & Molecular Biology
Cell Biology
Chiang J Y L
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Zhang M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/bi9018237" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/bi9018237</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2529-2539
Issue
11
Volume
49
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Title
A name given to the resource
Peroxynitrite-Mediated Oxidative Modifications of Complex II: Relevance in Myocardial Infarction
Publisher
An entity responsible for making the resource available
Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; cytochrome-c; fatty-acids; identification; membrane; mitochondrial; modulation; nitric-oxide; postischemic heart; succinate-ubiquinone; thiyl
Creator
An entity primarily responsible for making the resource
Zhang L W; Chen C L; Kang P T; Garg V; Hu K L; Green-Church K B; Chen Y R
Description
An account of the resource
Increased O-2(center dot-) and NO production is a key mechanism of mitochondrial dysfunction in mycocardial ischemia/reperfusion injury. In complex impairment and enhanced tyrosine nitration of the 70 kDa FAD-binding protein occur in the post-ischemic myocardium and are thought to be mediated by peroxynitrite (OONO-) ill vivo [Chen, Y.-R., et ill. (2008) J. Biol. Chem. 283, 27991-28003]. To gain deeper insights into the redox protein thiols involved ill OONO--mediated Oxidative post-translational modifications relevant ill myocardial infarction, We subjected Isolated myocardial complex 11 to ill vltro protein nitration with OONO-. This resulted ill site-specific nitration at the 70 kDa polypeptide and impairment of complex II-derived electron transfer activity. Under reducing conditions, the gel band of the 70 kDa POlyPePtldC MIS subjected to in-gel trypsin/chymotrypsin digestion and then LC-MS/MS analysis Nitration Of Y-56 and Y-142 was previosly reported. Further analysis revealed that C-267, C-476 and C-537 are involved ill OONO--mediated S-sulfonation. To identify the disulfide formation mediated by OONO-, nitrated complex 11 was alkylated with iodoacetamide. In-gel proteolytic digestion and LC-MS/MS analysis were conducted under nonreducing conditions. The MS/MS data were examined with MassMatrix, indicating that three cysteine pairs, C-306-C-312,C-439-C-444, and C-288-C-575, were involved in OONO--mediated disulfide formation. Immuno-spin trapping with an anti-DMPO antibody and subsequent MS Was used to define Oxidative modification with protein radical formation. An OONO--dependent DMPO adduct was detected. and further LC-MS/MS analysis indicated C-288 and C-655 were involved in DMPO binding. These I-CSLIltS offered a complete profile of OONO--mediated Oxidative modifications that may be relevant Ill the disease model of myocardial infarction.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bi9018237" target="_blank" rel="noreferrer noopener">10.1021/bi9018237</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2010
BIOCHEMISTRY
Biochemistry & Molecular Biology
Chen C L
Chen Y R
cytochrome-c
fatty-acids
Garg V
Green-Church K B
Hu K L
identification
Journal Article
Kang P T
membrane
Mitochondrial
modulation
nitric-oxide
postischemic heart
succinate-ubiquinone
thiyl
Zhang L W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
31
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Title
A name given to the resource
Histone Modification is a Novel Epigenetic Mechanism to Up-Regulate Human Blood-Brain Barrier Transporters
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
You D H; Wen X; Morris A; Richardson J R; Aleksunes L M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
Aleksunes L M
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Morris A
Richardson J R
Topics
Wen X
You D H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-291x(88)80881-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-291x(88)80881-7</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
576-580
Issue
1
Volume
156
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Title
A name given to the resource
THE COMPLETE NUCLEOTIDE-SEQUENCE OF HUMAN-LIVER CYTOCHROME-B5 MESSENGER-RNA
Publisher
An entity responsible for making the resource available
Biochemical and Biophysical Research Communications
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-10
Subject
The topic of the resource
Biochemistry & Molecular Biology; Biophysics
Creator
An entity primarily responsible for making the resource
Yoo M; Steggles A W
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-291x(88)80881-7" target="_blank" rel="noreferrer noopener">10.1016/s0006-291x(88)80881-7</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1988
Biochemical and biophysical research communications
Biochemistry & Molecular Biology
Biophysics
Journal Article
Steggles A W
Yoo M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-291x(89)92092-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-291x(89)92092-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
18-24
Issue
1
Volume
163
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Title
A name given to the resource
THE CHARACTERIZATION OF 3 TYPES OF PARTIALLY PROCESSED MESSENGER-RNA AND 2 PSEUDOGENES FOR HUMAN-LIVER CYTOCHROME-B5
Publisher
An entity responsible for making the resource available
Biochemical and Biophysical Research Communications
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-08
Subject
The topic of the resource
Biochemistry & Molecular Biology; Biophysics
Creator
An entity primarily responsible for making the resource
Yoo M; Steggles A W
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-291x(89)92092-5" target="_blank" rel="noreferrer noopener">10.1016/0006-291x(89)92092-5</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1989
Biochemical and biophysical research communications
Biochemistry & Molecular Biology
Biophysics
Journal Article
Steggles A W
Yoo M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Issue
1
Volume
28
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inducible vascular progenitor cells grown on the biodegradable polymer bundles in the cardiovascular regeneration
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Yin L Y; Ohanyan V; Enrick M; Stevanov K; Song H Y; Kolz C; Logan S; Newby B M Z; Chilian W
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2014
Biochemistry & Molecular Biology
Cell Biology
Chilian W
Enrick M
Faseb Journal
Journal Article
Kolz C
Life Sciences & Biomedicine - Other
Logan S
Newby B M Z
Ohanyan V
Song H Y
Stevanov K
Topics
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/elps.201000019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/elps.201000019</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1934-1936
Issue
12
Volume
31
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Simplified method for concentration of mitochondrial membrane protein complexes
Publisher
An entity responsible for making the resource available
Electrophoresis
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
Biochemistry & Molecular Biology; blue; Blue native PAGE; Chemistry; Complex I; Electrophoretic concentration; Mitochondria; native electrophoresis; oxidative-phosphorylation; polyacrylamide-gels; sds-page
Creator
An entity primarily responsible for making the resource
Yeh S T; Angelos M G; Chen Y R
Description
An account of the resource
Extracting and concentrating mitochondrial protein complexes from gel strips after blue native PAGE (BN-PAGE) can be daunting tasks using the traditional methods, such as electroelution, passive diffusion and centrifugal concentration. We present a simplified gel electrophoresis method to concentrate mitochondrial protein complexes with excellent recovery rate. Mitochondrial complex I present in a long gel strip from BN-PAGE can be easily concentrated into a 0.8 cm gel strip when a second BN-PAGE is performed with a Y-shaped gel and the addition of 0.01% n-dodecyl beta-D-maltoside and 0.001% SDS in the cathode buffer. Once completed, the concentrated protein complex in the gel strip is ready for SDS-PAGE or proteomic studies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/elps.201000019" target="_blank" rel="noreferrer noopener">10.1002/elps.201000019</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2010
Angelos M G
Biochemistry & Molecular Biology
blue
Blue native PAGE
Chemistry
Chen Y R
Complex I
Electrophoresis
Electrophoretic concentration
Journal Article
Mitochondria
native electrophoresis
oxidative-phosphorylation
polyacrylamide-gels
sds-page
Yeh S T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A37-A37
Issue
4
Volume
16
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of interleukin-1 beta on alveolar fluid clearance in preterm guinea pig lungs
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Ye X; Folkesson H G
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Folkesson H G
Journal Article
Life Sciences & Biomedicine - Other
Topics
Ye X
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s1388-1981(02)00186-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s1388-1981(02)00186-5</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
63-73
Issue
1
Volume
1583
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Title
A name given to the resource
On the mechanism of bile acid inhibition of rat sterol 12 alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4 alpha
Publisher
An entity responsible for making the resource available
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-06
Subject
The topic of the resource
activation; bile acid synthesise; Biochemistry & Molecular Biology; Biophysics; biosynthesis; Cell Biology; cholesterol 7-alpha-hydroxylase gene; Cyp7a1; cytochrome P450; expression; feedback-regulation; gene regulation; liver microsomal metabolism; nuclear receptor; promoter; receptor; repression
Creator
An entity primarily responsible for making the resource
Yang Y Z; Zhang M; Eggertsen G; Chiang J Y L
Description
An account of the resource
The sterol 12alpha-hydroxylase (CYP8B1) is a key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid (CA) and chenodeoxycholic acid (CDCA). In similarity with cholesterol 7alpha-hydroxylase (CYP7A1), this enzyme is subjected to a negative feedback regulation by bile acids, It has been recently reported that bile acid-activated famesoid X receptor (FXR) induces the small heterodimer partner (SHP) that interacts with alpha-fetoprotein transcription factor (FTF) and down-regulates CYP7A1 transcription. We studied whether the same mechanism also regulated rat CYP8B1 gene transcription. Feeding rats with CDCA caused a 40-50% decrease of CYP8B1 and hepatocyte nuclear factor 4alpha (HNF4alpha) mRNA expression levels. This was associated with an increase in FTF mRNA expression, but SHP mRNA expression was not altered. Electrophoretic mobility shift assay (EMSA) and transient transfection assay of promoter/reporter genes coupled to mutagenesis analysis identified a putative bile acid response element (BARE) that has an HNF4alpha binding site embedded in two overlapping FTF binding sites. Mutation of the HNF4alpha binding site markedly reduced basal promoter activity and its repression by bile acids. Cotransfection with FTF strongly repressed CYP8B1 transcription. Interestingly, HNF4alpha could overcome the inhibitory effects of FTF and bile acids. We conclude that FTF and HNF4alpha not only play critical roles on CYP8B1 gene transcription, but also mediate bile acid feedback inhibition. This study reveals a novel mechanism by which bile acids inhibit rat CYP8B1 gene transcription by inducing FTF and inhibiting HNF4alpha expression. (C) 2002 Elsevier Science B.V. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s1388-1981(02)00186-5" target="_blank" rel="noreferrer noopener">10.1016/s1388-1981(02)00186-5</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
activation
bile acid synthesise
Biochemistry & Molecular Biology
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
Biophysics
biosynthesis
Cell Biology
Chiang J Y L
cholesterol 7-alpha-hydroxylase gene
CYP7A1
cytochrome P450
Eggertsen G
expression
feedback-regulation
Gene Regulation
Journal Article
liver microsomal metabolism
Nuclear Receptor
promoter
Receptor
repression
Yang Y Z
Zhang M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bbrc.2004.06.069" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bbrc.2004.06.069</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1204-1210
Issue
4
Volume
320
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Title
A name given to the resource
Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12 alpha-hydroxylase gene (CYP8B1)
Publisher
An entity responsible for making the resource available
Biochemical and Biophysical Research Communications
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-08
Subject
The topic of the resource
bile acids; bile-acid metabolism; Biochemistry & Molecular Biology; Biophysics; cholesterol; CYP8B1; gene regulation; liver; mice; mouse; pathway; promoter; rat; receptor lxr-alpha; SREBP; srebps; suppresses
Creator
An entity primarily responsible for making the resource
Yang Y Z; Eggertsen G; Gafvels M; Andersson U; Einarsson C; Bjorkhem I; Chiang J Y L
Description
An account of the resource
Sterol 12alpha-hydroxylase (CYP8B1) is an obligatory enzyme for the synthesis of cholic acid and regulation of liver bile acid synthesis and intestine cholesterol absorption. The present study evaluates the roles for sterol regulatory element binding proteins (SREBPs) in the regulation of the CYP8B1 gene. Cholesterol feeding of mice and rats decreased the activity of CYP8B1, contrary to the up-regulation of cholesterol 7alpha-hydroxylase (CYP7A1). Cholesterol feeding also reduced mRNA levels for SREBP-1 but not for SREBP-2 in rat livers. Cholesterol and 25-hydroxycholesterol decreased the CYP8B1/luciferase reporter activity. Co-transfection of SREBP-1a and -1c stimulated CYP8B1 promoter activity, while SREBP-2 did not have any effects. Electrophoretic mobility shift assay and mutagenesis analyses identified several functional sterol regulatory elements (SRE) and E-box motifs in the rat CYP8B1 promoter. Our results indicate that SREBP-1a and -1c enhance transcription of the CYP8B1 gene through binding to SRE. Cholesterol loading reduces SREBP-1 mRNA expression in addition to reducing functional SREBP-1 protein, and results in decreasing CYP8B1 gene transcription. (C) 2004 Elsevier Inc. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bbrc.2004.06.069" target="_blank" rel="noreferrer noopener">10.1016/j.bbrc.2004.06.069</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2004
Andersson U
BILE acids
bile-acid metabolism
Biochemical and biophysical research communications
Biochemistry & Molecular Biology
Biophysics
Bjorkhem I
Chiang J Y L
Cholesterol
CYP8B1
Eggertsen G
Einarsson C
Gafvels M
Gene Regulation
Journal Article
Liver
Mice
mouse
pathway
promoter
rat
receptor lxr-alpha
SREBP
srebps
suppresses
Yang Y Z
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.matbio.2006.08.195" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.matbio.2006.08.195</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S71-S71
Volume
25
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Title
A name given to the resource
BAG-1 modulates endoplasmic reticulum stress in chondrocytes
Publisher
An entity responsible for making the resource available
Matrix Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-11
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology
Creator
An entity primarily responsible for making the resource
Yang L; Carlson S G; McBurney D; Horton W E
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.matbio.2006.08.195" target="_blank" rel="noreferrer noopener">10.1016/j.matbio.2006.08.195</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
Biochemistry & Molecular Biology
Carlson S G
Cell Biology
Horton W E
Journal Article
Matrix Biology
McBurney D
Yang L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1471-4159.1992.tb10048.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1471-4159.1992.tb10048.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1736-1742
Issue
5
Volume
58
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Title
A name given to the resource
DOPAMINERGIC MODULATION OF GLUTAMATE RELEASE IN STRIATUM AS MEASURED BY MICRODIALYSIS
Publisher
An entity responsible for making the resource available
Journal of Neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-05
Subject
The topic of the resource
afferents; amino-acid neurotransmitters; aspartate; Biochemistry & Molecular Biology; brain-tissue; corticostriatal path; d2 receptors; dopamine; endogenous glutamate; glutamate; in-vivo; lesion; microdialysis; nerve-terminals; Neurosciences & Neurology; pathway; rat caudate-putamen
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Davy S
Description
An account of the resource
Glutamate and aspartate are the primary neurotransmitters of projections from motor and premotor cortices to the striatum. Release of glutamate may be modulated by dopamine receptors located on corticostriatal terminals. The present study used microdialysis to investigate the dopaminergic modulation of in vivo striatal glutamate and aspartate release in the striatum of awake-behaving rats. Local perfusion with a depolarizing concentration of K+ through a dialysis probe into the rat striatum produced a significant increase in the release of glutamate, aspartate, and taurine. The D2 agonist LY171555 blocked the K+-induced release of glutamate and aspartate, but not taurine, in a concentration-dependent manner. The D1 agonist SKF 38393 did not alter K+-induced release of glutamate and taurine, but did significantly decrease aspartate release. Neither agonist had any effect on basal amino acid release. The D2 antagonist (-)-sulpiride reversed the inhibitory effects of LY 171555 on K+-induced glutamate release. These results provide in vivo evidence for a functional interaction between dopamine, the D2 receptor, and striatal glutamate release.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1471-4159.1992.tb10048.x" target="_blank" rel="noreferrer noopener">10.1111/j.1471-4159.1992.tb10048.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1992
afferents
amino-acid neurotransmitters
aspartate
Biochemistry & Molecular Biology
brain-tissue
corticostriatal path
d2 receptors
Davy S
Dopamine
endogenous glutamate
glutamate
in-vivo
Journal Article
Journal of neurochemistry
lesion
Microdialysis
nerve-terminals
Neurosciences & Neurology
pathway
rat caudate-putamen
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
30
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Title
A name given to the resource
Carboxylesterase 1 Protects Against Liver Injury and Is Regulated by Hepatocyte Nuclear Factor 4 alpha
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Xu J S; Xu Y; Zhang Y Q
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2016
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Xu J S
Xu Y
Zhang Y Q
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hep.26714" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep.26714</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
29
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Title
A name given to the resource
Hepatic Carboxylesterase 1 is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Xu J S; Li Y Y; Xu Y
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/hep.26714" target="_blank" rel="noreferrer noopener">10.1002/hep.26714</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2015
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Li Y Y
Life Sciences & Biomedicine - Other
Topics
Xu J S
Xu Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1471-4159.2004.02834.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1471-4159.2004.02834.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
59-71
Issue
1
Volume
92
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice
Publisher
An entity responsible for making the resource available
Journal of Neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
amyotrophic lateral sclerosis; amyotrophic lateral sclerosis; anterior horn; antisense oligonucleotides; apoptosis; apoptosis response-4; Biochemistry & Molecular Biology; cells; Cu/Zn superoxide dismutase; motor-neuron degeneration; neurons; Neurosciences & Neurology; prostate; protein; RNA interference; sod1; spinal motor neurons; synapse; synapses; transgenic mouse model
Creator
An entity primarily responsible for making the resource
Xie J; Awad K S; Guo Q
Description
An account of the resource
Evidence from human amyotrophic lateral sclerosis (ALS) patients and ALS-linked Cu/Zn superoxide dismutase (Cu/Zn-SOD) transgenic mice bearing the mutation of glycine to alanine at position 93 (G93A) suggests that the pro-apoptotic protein prostate apoptosis response-4 (Par-4) might be a critical link in the chain of events leading to motor neuron degeneration. We now report that Par-4 is enriched in synaptosomes and post-synaptic density from the ventral horn of the spinal cord. Levels of Par-4 in synaptic compartments increased significantly during rapid and slow declining stages of muscle strength in hSOD1 G93A mutant mice. In the pre-muscle weakness stage, hSOD1 G93A mutation sensitized synaptosomes from the ventral horn of the spinal cord to increased levels of Par-4 expression following excitotoxic and apoptotic insults. In ventral spinal synaptosomes, Par-4-mediated production of pro-apoptotic cytosolic factor(s) was significantly enhanced by the hSOD1 G93A mutation. RNA interference (RNAi) knockdown of Par-4 inhibited mitochondrial dysfunction and caspase-3 activation induced by G93A mutation in synaptosomes from the ventral horn of the spinal cord, and protected spinal motor neurons from apoptosis. These results identify the synapse as a crucial cellular site for the cell death promoting actions of Par-4 in motor neurons, and suggest that targeted inhibition of Par-4 by RNAi may prove to be a neuroprotective strategy for motor neuron degeneration.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1471-4159.2004.02834.x" target="_blank" rel="noreferrer noopener">10.1111/j.1471-4159.2004.02834.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
amyotrophic lateral sclerosis
anterior horn
antisense oligonucleotides
Apoptosis
apoptosis response-4
Awad K S
Biochemistry & Molecular Biology
Cells
Cu/Zn superoxide dismutase
Guo Q
Journal Article
Journal of neurochemistry
motor-neuron degeneration
Neurons
Neurosciences & Neurology
Prostate
Protein
RNA Interference
sod1
spinal motor neurons
synapse
synapses
transgenic mouse model
Xie J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2195-2203
Issue
12
Volume
40
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Title
A name given to the resource
Structure and functions of human oxysterol 7 alpha-hydroxylase cDNAs and gene CYP7B1
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-12
Subject
The topic of the resource
27-hydroxycholesterol; 7-alpha-hydroxylase; bile-acid synthesis; bile-acid synthesis; Biochemistry & Molecular Biology; brain; cholesterol; cholesterol 7 alpha-hydroxylase; cytochrome P450; cytochrome P450; dehydroepiandrosterone (DHEA); dehydroepiandrosterone (DHEA); human liver-microsomes; identification; neurosteroids; transcription
Creator
An entity primarily responsible for making the resource
Wu Z L; Martin K O; Javitt N B; Chiang J Y L
Description
An account of the resource
Oxysterol 7 alpha-hydroxylase has broad substrate specificity for sterol metabolites and may be involved in many metabolic processes including bile acid synthesis and neurosteroid metabolism, The cloned human oxysterol 7 alpha-hydroxylase (CYP7B1) cDNA encodes a polypeptide of 506 amino acid residues that shares 40% sequence identity to human cholesterol 7 alpha-hydroxylase (CW7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. In contrast to the liver-specific expression of CYP7A1, CYP7B1 mRNA transcripts were detected in human tissues involved in steroid genesis (brain, testes, ovary, and prostate) and in bile acid synthesis (liver) and reabsorption (colon, kidney, and small intestine). The human oxysterol 7 alpha-hydroxylase transiently expressed in 293/T cells was able to catalyze 7 alpha-hydroxylation of 27-hydroxycholesterol and dehydroepiandrosterone (DHEA), The human CYP7A1 and CYP7B1 both contain six exons and five introns. However, CPP7B1 spans at least 65 kb of the genome and is about 6-fold longer than CYP7A1. The transcription start site (+1) was localized 204 bp upstream of the initiation codon, No TATA box-like sequence was found near the transcription start site. Transient transfection assays of CYP7B1 promoter/luciferase reporter constructs in HepG2 cells revealed that the promoter was highly active. The 5' upstream region from nt -83 to +189 is the core promoter of the gene.
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1999
27-hydroxycholesterol
7-alpha-hydroxylase
bile-acid synthesis
Biochemistry & Molecular Biology
Brain
Chiang J Y L
Cholesterol
cholesterol 7 alpha-hydroxylase
cytochrome P450
dehydroepiandrosterone (DHEA)
human liver-microsomes
identification
Javitt N B
Journal Article
Journal of lipid research
Martin K O
neurosteroids
Transcription
Wu Z L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1014-A1014
Issue
5
Volume
13
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cloning of the human oxysterol 7 alpha-hydroxylase cDNA and the gene CYP7B
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Wu Z L; Martin K O; Javitt N B; Chiang J Y L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1999
Biochemistry & Molecular Biology
Cell Biology
Chiang J Y L
Faseb Journal
Javitt N B
Journal Article
Life Sciences & Biomedicine - Other
Martin K O
Topics
Wu Z L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/php.12359" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/php.12359</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
27-32
Issue
1
Volume
91
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Title
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Oculocutaneous Albinism in Sub-Saharan Africa: Adverse Sun-Associated Health Effects and Photoprotection
Publisher
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Photochemistry and Photobiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-01
Subject
The topic of the resource
Biochemistry & Molecular Biology; Biophysics; care; children; community; Nigeria; northern tanzania; population; program; skin cancer; southern-africa; zimbabwe
Creator
An entity primarily responsible for making the resource
Wright C Y; Norval M; Hertle R W
Description
An account of the resource
Oculocutaneous albinism (OCA) is a genetically inherited autosomal recessive condition. Individuals with OCA lack melanin and therefore are susceptible to the harmful effects of solar ultraviolet radiation, including extreme sun sensitivity, photophobia and skin cancer. OCA is a grave public health issue in sub-Saharan Africa with a prevalence as high as 1 in 1000 in some tribes. This article considers the characteristics and prevalence of OCA in sub-Saharan African countries. Sun-induced adverse health effects in the skin and eyes of OCA individuals are reviewed. Sun exposure behavior and the use of photoprotection for the skin and eyes are discussed to highlight the major challenges experienced by these at-risk individuals and how these might be best resolved.
Identifier
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<a href="http://doi.org/10.1111/php.12359" target="_blank" rel="noreferrer noopener">10.1111/php.12359</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2015
Biochemistry & Molecular Biology
Biophysics
care
Children
Community
Hertle R W
Journal Article
Nigeria
northern tanzania
Norval M
Photochemistry and Photobiology
Population
program
skin cancer
southern-africa
Wright C Y
zimbabwe
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/hmg/ddy344" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/hmg/ddy344</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
525-538
Issue
4
Volume
28
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Title
A name given to the resource
Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease
Publisher
An entity responsible for making the resource available
Human Molecular Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
1905-7
Subject
The topic of the resource
Adult; Biochemistry & Molecular Biology; Catalytic Domain; Child; Female; gene; Genetic Diseases; Genetic Predisposition to Disease; Genetics & Heredity; Hearing Loss; Heterozygote; Homozygote; Humans; impairment; Inborn; Infant; lactic-acidosis; Loss of Function Mutation; Male; mechanisms; Mutation; myopathy; Newborn; onset; Pedigree; Phenotype; phenotypic variability; Preschool; recessive mutations; Sensorineural; Severity of Illness Index; swiss-model; Tyrosine-tRNA Ligase; variant; Whole Exome Sequencing; Yeasts
Creator
An entity primarily responsible for making the resource
Williams Katie B; Brigatti Karlla W; Puffenberger Erik G; Gonzaga-Jauregui Claudia; Griffin Laurie B; Martinez Erick D; Wenger Olivia K; Yoder Mark A; Kandula Vinay V R; Fox Michael D; Demczko Matthew M; Poskitt Laura; Furuya Katryn N; Reid Jeffrey G; Overton John D; Baras Aris; Miles Lili; Radhakrishnan Kadakkal; Carson Vincent J; Antonellis Anthony; Jinks Robert N; Strauss Kevin A
Description
An account of the resource
Aminoacyl-tRNA synthetases (ARSs) are critical for protein translation. Pathogenic variants of ARSs have been previously associated with peripheral neuropathy and multisystem disease in heterozygotes and homozygotes, respectively. We report seven related children homozygous for a novel mutation in tyrosyl-tRNA synthetase (YARS, c.499C > A, p.Pro167Thr) identified by whole exome sequencing. This variant lies within a highly conserved interface required for protein homodimerization, an essential step in YARS catalytic function. Affected children expressed a more severe phenotype than previously reported, including poor growth, developmental delay, brain dysmyelination, sensorineural hearing loss, nystagmus, progressive cholestatic liver disease, pancreatic insufficiency, hypoglycemia, anemia, intermittent proteinuria, recurrent bloodstream infections and chronic pulmonary disease. Related adults heterozygous for YARS p.Pro167Thr showed no evidence of peripheral neuropathy on electromyography, in contrast to previous reports for other YARS variants. Analysis of YARS p.Pro167Thr in yeast complementation assays revealed a loss-of-function, hypomorphic allele that significantly impaired growth. Recombinant YARS p.Pro167Thr demonstrated normal subcellular localization, but greatly diminished ability to homodimerize in human embryonic kidney cells. This work adds to a rapidly growing body of research emphasizing the importance of ARSs in multisystem disease and significantly expands the allelic and clinical heterogeneity of YARS-associated human disease. A deeper understanding of the role of YARS in human disease may inspire innovative therapies and improve care of affected patients.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/hmg/ddy344" target="_blank" rel="noreferrer noopener">10.1093/hmg/ddy344</a>
2019
Adult
Antonellis Anthony
Baras Aris
Biochemistry & Molecular Biology
Brigatti Karlla W
Carson Vincent J
Catalytic Domain
Child
Demczko Matthew M
Female
Fox Michael D
Furuya Katryn N
gene
Genetic Diseases
Genetic Predisposition to Disease
Genetics & Heredity
Gonzaga-Jauregui Claudia
Griffin Laurie B
Hearing Loss
Heterozygote
Homozygote
Human molecular genetics
Humans
impairment
Inborn
Infant
Jinks Robert N
Kandula Vinay V R
lactic-acidosis
Loss of Function Mutation
Male
Martinez Erick D
mechanisms
Miles Lili
Mutation
myopathy
NEOMED College of Medicine Student
NEOMED Student Publications
Newborn
onset
Overton John D
Pedigree
Phenotype
phenotypic variability
Poskitt Laura
Preschool
Puffenberger Erik G
Radhakrishnan Kadakkal
recessive mutations
Reid Jeffrey G
Sensorineural
September 2019 Update
Severity of Illness Index
Strauss Kevin A
swiss-model
Tyrosine-tRNA Ligase
variant
Wenger Olivia K
Whole Exome Sequencing
Williams Katie B
Yeasts
Yoder Mark A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0009-3084(82)90031-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0009-3084(82)90031-7</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
381-387
Issue
4
Volume
30
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Title
A name given to the resource
SYNTHESIS OF ESTERS OF TETRADECANOIC ACID DEUTERATED AT THE PENULTIMATE CARBON - SOME GENERAL PROCEDURES FOR THE SYNTHESIS OF SELECTIVELY DEUTERATED FATTY-ACIDS
Publisher
An entity responsible for making the resource available
Chemistry and Physics of Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
1982
1982
Subject
The topic of the resource
Biochemistry & Molecular Biology; Biophysics
Creator
An entity primarily responsible for making the resource
Westerman P W; Ghrayeb N
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0009-3084(82)90031-7" target="_blank" rel="noreferrer noopener">10.1016/0009-3084(82)90031-7</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1982
Biochemistry & Molecular Biology
Biophysics
Chemistry and Physics of Lipids
Ghrayeb N
Journal Article
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0009-3084(81)90068-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0009-3084(81)90068-2</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
351-358
Issue
4
Volume
29
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Title
A name given to the resource
SYNTHESIS OF METHYL OMEGA-DEUTERATED TETRADECANOATE AND HEXADECANOATE
Publisher
An entity responsible for making the resource available
Chemistry and Physics of Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
1981
1981
Subject
The topic of the resource
Biochemistry & Molecular Biology; Biophysics
Creator
An entity primarily responsible for making the resource
Westerman P W; Ghrayeb N
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0009-3084(81)90068-2" target="_blank" rel="noreferrer noopener">10.1016/0009-3084(81)90068-2</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1981
Biochemistry & Molecular Biology
Biophysics
Chemistry and Physics of Lipids
Ghrayeb N
Journal Article
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2478-2492
Issue
12
Volume
36
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Title
A name given to the resource
Physicochemical characterization of a model digestive mixture by H-2 NMR
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
adult human-beings; bile salts; bile-salt; biliary lipid systems; Biochemistry & Molecular Biology; c-13 nmr; cholesterol; contents; digestion; fat; H-2-labeled lipids; human intestinal; intestinal lipids; liquid-crystalline phases; nuclear magnetic-resonance; phosphatidylcholine mixed micelles; physical-chemical behavior
Creator
An entity primarily responsible for making the resource
Westerman P W
Description
An account of the resource
H-2 nuclear magnetic resonance (NMR) spectra were obtained at 30.87 MHz for 8% (w/v) aqueous dispersions of mixtures of bile salts (MBS), mixed intestinal lipids (MIL; myristic acid, monomyristoylglycerol dimyristoylphos-phatidylcholine = 5:1:1), and cholesterol, in which a single lipid component is selectively H-2-labeled. Using the observation that the time averaged quadrupole splitting of a (CH3)-H-2 group varies according to whether it exists in a micellar, multilamellar or solid phase, one-, two-, and three-phase regions in the equilibrium phase diagram have been identified. From the intensities of the singlets and powder patterns in the wide-line H-2 NMR spectra, the relative amounts of these organized molecular assemblies were determined. With different (CH3)-H-2-labeled components in samples of identical total composition, the chemical composition of each phase was calculated for one point (20 mol % cholesterol; 50 mol % MIL, and 30 mol % MBS) in a two-phase region of the phase diagram where the H-2 NMR spectrum displayed both a sharp spectral component and a broad uniaxial powder pattern. X-ray diffraction measurements on this sample confirmed that the uniaxial powder pattern in the NMR spectra can be assigned to multilamellar vesicles. At this same point in the phase diagram with the H-2 label on the a-methylene site of myristic acid, both narrow and broad (Delta v = 37 kHz) spectral components were again observed. Relaxation time (T-1 and T?) measurements of the sharp spectral component indicate that this peak arises from rapidly tumbling aggregates which, at a total lipid concentration of 8% (w/v), are micellar particles and not unilamellar vesicles. These experiments demonstrate the feasibility of structural investigations of model digestive mixtures by H-2 NMR.
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1995
adult human-beings
bile salts
bile-salt
biliary lipid systems
Biochemistry & Molecular Biology
c-13 nmr
Cholesterol
contents
digestion
fat
H-2-labeled lipids
human intestinal
intestinal lipids
Journal Article
Journal of lipid research
liquid-crystalline phases
nuclear magnetic-resonance
phosphatidylcholine mixed micelles
physical-chemical behavior
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1258-A1258
Issue
7
Volume
7
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
PHYSICOCHEMICAL CHARACTERIZATION OF AQUEOUS LIPID PHASES OF RELEVANCE TO INTESTINAL FAT DIGESTION AND ABSORPTION - A H-2 NMR-STUDY
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Westerman P W
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1993
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A375-A375
Issue
1
Volume
6
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
PHYSICOCHEMICAL CHARACTERIZATION OF DIETARY AND BILIARY LIPIDS DURING INTESTINAL DIGESTION AND ABSORPTION - A H-2 NMR-STUDY
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-01
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Westerman P W
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1992
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A60-A60
Issue
4
Volume
8
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Title
A name given to the resource
EXPRESSION OF SLOW-TONIC MYOSIN HEAVY-CHAIN IS AFFERENT-DEPENDENT IN REGENERATED RAT MUSCLE-SPINDLES
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Wang J; Walro J M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1994
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Walro J M
Wang J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1383-A1383
Issue
7
Volume
8
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Title
A name given to the resource
TRANSCRIPTIONAL REGULATION OF HUMAN CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE IN HEPG2 CELLS
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Wang D P; Karam W G; Chiang J Y L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1994
Biochemistry & Molecular Biology
Cell Biology
Chiang J Y L
Faseb Journal
Journal Article
Karam W G
Life Sciences & Biomedicine - Other
Topics
Wang D P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/bi00276a005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/bi00276a005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1547-1556
Issue
7
Volume
22
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Title
A name given to the resource
SPECIES-DIFFERENCES IN CYTOCHROMES-P-450 AND EPOXIDE HYDROLASE - COMPARISONS OF XENOBIOTIC-INDUCED HEPATIC-MICROSOMAL POLYPEPTIDES IN HAMSTERS AND RATS
Publisher
An entity responsible for making the resource available
Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1983
1983
Subject
The topic of the resource
Biochemistry & Molecular Biology
Creator
An entity primarily responsible for making the resource
Walz F G; Vlasuk G P; Steggles A W
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bi00276a005" target="_blank" rel="noreferrer noopener">10.1021/bi00276a005</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1983
BIOCHEMISTRY
Biochemistry & Molecular Biology
Journal Article
Steggles A W
Vlasuk G P
Walz F G
-
Text
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n/a
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Pages
A117-A117
Issue
4
Volume
16
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Dublin Core
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Postnatal maturation of cardiac beta-adrenergic receptors innerve growth factor(NGF)-deficient mice
Publisher
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Faseb Journal
Date
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2002
2002-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
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Walro J M; Morgan E; Anderson L I; Story G M
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n/a
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Journal Article
2002
Anderson L I
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Morgan E
Story G M
Topics
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A236-A236
Issue
4
Volume
19
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Cardiac sympathetic innervation is reduced in NGF-deficient Bax knockout mice
Publisher
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Faseb Journal
Date
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2005
2005-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
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Walro J M; May L E
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n/a
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Journal Article
2005
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
May L E
Topics
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A929-A929
Issue
4
Volume
9
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VASOACTIVE-INTESTINAL-PEPTIDE EFFECTS ON A DOG RIGHT ATRIAL PREPARATION
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
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Wallick D W; Stuesse S L; Martin P J
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n/a
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Journal Article
1995
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Martin P J
Stuesse S L
Topics
Wallick D W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Pages
S70-S70
Issue
4
Volume
143
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Title
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Anatomical and functional specializations of the anterior temporalis muscle of baboons as revealed by fiber type, fiber architecture, and EMG
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Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology
Date
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2006
2006-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Physiology; Zoology
Creator
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Wall C; Briggs M; Schachat F; Hylander W; Vinyard C; Williams S
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n/a
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Journal Article
2006
Biochemistry & Molecular Biology
Briggs M
Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology
Hylander W
Journal Article
Physiology
Schachat F
Vinyard C
Wall C
Williams S
Zoology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
24
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Separate but equal? Relating morphological divergence to functional performance in the evolution of primate chewing
Publisher
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Faseb Journal
Date
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2010
2010-04
Subject
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Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
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Vinyard C J
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n/a
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Journal Article
2010
Biochemistry & Molecular Biology
Cell Biology
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Vinyard C J