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Text
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URL Address
<a href="http://doi.org/10.1016/j.bmc.2006.09.060" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmc.2006.09.060</a>
Pages
1525–1532
Issue
3
Volume
15
Dublin Core
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Title
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Structure-activity relationships of pentacycloundecylamines at the
Publisher
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Bioorganic & medicinal chemistry
Date
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2007
2007-02
Subject
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Amines/chemical synthesis/chemistry/*pharmacology; Animals; Brain/drug effects; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/*pharmacology; Inbred ICR; Ion Channels; Male; Mice; Models; Molecular; N-Methyl-D-Aspartate/*antagonists & inhibitors; Phencyclidine/analogs & derivatives; Piperidines/pharmacology; Radioligand Assay; Receptors; Structure-Activity Relationship; Synaptosomes/*drug effects; Thiophenes/pharmacology
Creator
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Geldenhuys Werner J; Malan Sarel F; Bloomquist Jeffrey R; Van der Schyf Cornelis J
Description
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Prompted by our interest in neuroprotective agents with multiple mechanisms of action, we assessed the structure-activity relationship of a series of pentacycloundecylamine derivatives previously shown to have both L-type calcium channel blocking activity and N-methyl-d-aspartate receptor (NMDAR) antagonistic activity. We utilized a functional assay to measure NMDAR channel block using (45)Ca(2+) influx into synaptoneurosomes. The cage amine
Identifier
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<a href="http://doi.org/10.1016/j.bmc.2006.09.060" target="_blank" rel="noreferrer noopener">10.1016/j.bmc.2006.09.060</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Amines/chemical synthesis/chemistry/*pharmacology
Animals
Bioorganic & medicinal chemistry
Bloomquist Jeffrey R
Brain/drug effects
Dizocilpine Maleate/pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Geldenhuys Werner J
Inbred ICR
Ion Channels
Malan Sarel F
Male
Mice
Models
Molecular
N-Methyl-D-Aspartate/*antagonists & inhibitors
Phencyclidine/analogs & derivatives
Piperidines/pharmacology
Radioligand Assay
Receptors
Structure-Activity Relationship
Synaptosomes/*drug effects
Thiophenes/pharmacology
Van der Schyf Cornelis J