Acute Tramadol Ingestion With Transient Acute Kidney Injury in an Adolescent Female.
acute kidney injury; DRUG side effects; adolescent; tramadol; ACUTE kidney failure; case report; adverse drug effect; analgesics; drug overdose; RHABDOMYOLYSIS; STRIATED muscle necrosis; TRAMADOL
Renal toxicity has been described with tramadol overdoses; however, it is typically associated with rhabdomyolysis, multiorgan failure and/or mortality. Our patient was a 16-year-old female who was evaluated following an intentional tramadol ingestion, estimated 27.8 to 37 mg/kg, and had a seizure prior to arriving at our health care facility. Her symptoms were consistent with a tramadol ingestion; however, she developed transient acute renal impairment (peak serum creatinine, 4.04 mg/dL), which improved over 6 days with minimal intervention. No other causes were identified to explain her acute renal impairment thus it was attributed to the tramadol overdose. Providers should be aware that transient acute renal impairment could occur with an intentional tramadol ingestion and may not require aggressive intervention. [ABSTRACT FROM AUTHOR]
Mike TB; DeVault H; Blackford MG
Journal Of Pediatric Pharmacology & Therapeutics
2021
2021-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.5863/1551-6776-26.4.411" target="_blank" rel="noreferrer noopener">10.5863/1551-6776-26.4.411</a>
A burn center paradigm to fulfill deferred consent public disclosure and community consultation requirements for emergency care research.
United States; Health Services Research; Human; Truth Disclosure; Consent; Community-Institutional Relations; Government Regulations; Burn Units – Legislation and Jurisprudence; Burns – Therapy
INTRODUCTION: To fulfill Food and Drug Administration and Department of Health and Human Services emergency care research informed consent requirements, our burn center planned and executed a deferred consent strategy gaining Institutional Review Board (IRB) approval to proceed with the clinical study. These federal regulations dictate public disclosure and community consultation unique to acute care research. OBJECTIVE: Our regional burn center developed and implemented a deferred consent public notification and community consultation paradigm appropriate for a burn study. METHODS: Published accounts of deferred consent strategies focus on acute care resuscitation practices. We adapted those strategies to design and conduct a comprehensive public notification/community consultation plan to satisfy deferred consent requirements for burn center research. RESULTS: To implement a robust media campaign we engaged the hospital's public relations department, distributed media materials, recruited hospital staff for speaking engagements, enlisted community volunteers, and developed initiatives to inform 'hard-to-reach' populations. The hospital's IRB determined we fulfilled our obligation to notify the defined community. CONCLUSION: Our communication strategy should provide a paradigm other burn centers may appropriate and adapt when planning and executing a deferred consent initiative.
Blackford MG; Falletta L; Andrews DA; Reed MD
Burns (03054179)
2012
2012-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.burns.2012.02.009" target="_blank" rel="noreferrer noopener">10.1016/j.burns.2012.02.009</a>