1
40
9
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1089/gte.2007.0050" target="_blank" rel="noreferrer noopener">http://doi.org/10.1089/gte.2007.0050</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
427-444
Issue
4
Volume
11
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Targeted Extended Cystic Fibrosis Mutation Testing On Known And At-risk Patients And Relatives
Publisher
An entity responsible for making the resource available
Genetic Testing
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-12
Subject
The topic of the resource
blood; cftr mutations; early-diagnosis; experience; Genetics & Heredity; immunoreactive trypsinogen; midlands; newborn; outcomes; Research & Experimental Medicine; vas-deferens; west; wisconsin
Creator
An entity primarily responsible for making the resource
Lebo R V; Omlor G J
Description
An account of the resource
This paper reports mathematically derived residual risks of being a carrier or being affected with cystic fibrosis following various screening scenarios to assist in interpreting test results and advising patients. While parental screening with 23 American College of Medical Genetics (ACMG) cystic fibrosis mutations defines the 64% of affected U. S. Caucasian fetuses with two detectable mutations, newborn screening for elevated immunoreactive trypsinogen (IRT) and sweat chloride identifies an additional 36% of affected newborns with zero or one detected mutation. The relatives of these affected newborns with less than two detectable mutations have higher posterior (after) 23 mutation-negative test risks of carrying undetected mutations. These calculations emphasize how knowledge of the mutations in the related affected patient substantially improves upon the quality of after-test advice to patients. Furthermore, negative tests of the partner without a family history and/or more extensive cystic fibrosis transmembrane conductance regulator (CFTR) gene testing also increases the likelihood that a negative report is truly negative. When a newborn patient with zero or one detected CFTR mutation has an inconclusive sweat test result, the sweat test should be repeated before ordering additional often unnecessary CFTR gene sequencing. Given the same composite mutation panel test accuracy, a higher proportion of reported test results would be correct during parental screening than when testing at-risk fetuses or symptomatic newborns. Prenatal and newborn screening would be enhanced substantially by medical professionals offering copies of all positive parental and newborn test reports to the parents to share with their relatives. These principles are likely to be applicable to other genetic diseases as the most common mutation frequencies are reported.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/gte.2007.0050" target="_blank" rel="noreferrer noopener">10.1089/gte.2007.0050</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
Blood
cftr mutations
early-diagnosis
experience
Genetic Testing
Genetics & Heredity
immunoreactive trypsinogen
Journal Article or Conference Abstract Publication
Lebo R V
midlands
Newborn
Omlor G J
outcomes
Research & Experimental Medicine
vas-deferens
west
Wisconsin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
649-649
Issue
21
Volume
118
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Outcomes In Obese And Overweight Acute Myeloid Leukemia (aml) Patients Receiving Chemotherapy Dosed According To Actual Body Weight
Publisher
An entity responsible for making the resource available
Blood
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Hematology
Creator
An entity primarily responsible for making the resource
Gallagher E M; Earl M; Yeh J Y; Kusick K; Kruse J; Swann C; Smith A; Davis R; Advani A S; Kalaycio M; Copelan E A; Sekeres M A
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
Advani A S
Blood
Copelan E A
Davis R
Earl M
Gallagher E M
Hematology
Kalaycio M
Kruse J
Kusick K
Sekeres M A
Smith A
Swann C
Yeh J Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1182/blood-2018-99-116584" target="_blank" rel="noreferrer noopener">http://doi.org/10.1182/blood-2018-99-116584</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Volume
132
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sickle Cell Disease Patients Demonstrate a High Willingness to Participate in Randomized Clinical Trials
Publisher
An entity responsible for making the resource available
Blood
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-11
Subject
The topic of the resource
Hematology
Creator
An entity primarily responsible for making the resource
Mazziotto V; Mikofalvy K; Houck A; Beck L; Bodas P V
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1182/blood-2018-99-116584" target="_blank" rel="noreferrer noopener">10.1182/blood-2018-99-116584</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2018
Beck L
Blood
Bodas P V
Hematology
Houck A
Journal Article or Conference Abstract Publication
Mazziotto V
Mikofalvy K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
44-48
Issue
1
Volume
57
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CLOT RETRACTION FACILITATES CLOT LYSIS
Publisher
An entity responsible for making the resource available
Blood
Date
A point or period of time associated with an event in the lifecycle of the resource
1981
1981
Subject
The topic of the resource
Hematology
Creator
An entity primarily responsible for making the resource
Carroll R C; Gerrard J M; Gilliam J M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1981
Blood
Carroll R C
Gerrard J M
Gilliam J M
Hematology
Journal Article or Conference Abstract Publication
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1182/blood-2007-10-118497" target="_blank" rel="noreferrer noopener">http://doi.org/10.1182/blood-2007-10-118497</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
256-263
Issue
2
Volume
112
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues
Publisher
An entity responsible for making the resource available
Blood
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-07
Subject
The topic of the resource
in-vitro; central-nervous-system; Hematology; blood-brain-barrier; ccx-ckr; cutting edge; d6; dendritic cell; experimental autoimmune encephalomyelitis; immune-response; sjogrens-syndrome
Creator
An entity primarily responsible for making the resource
Cardona A E; Sasse M E; Liu L P; Cardona S M; Mizutani M; Savarin C; Hu T; Ransohoff R M
Description
An account of the resource
In vitro studies have implicated chemokine receptors in consumption and clearance of specific ligands. We studied the role that various signaling chemokine receptors play during ligand homeostasis in vivo. We examined the levels of ligands in serum and CNS tissue in mice lacking chemokine receptors. Compared with receptor-sufficient controls, Cx3cr1(-/-) mice exhibited augmented levels of CX3CL1 both in serum and brain, and circulating levels of CXCL1 and CXCL2 were increased in Cxcr2(-/-) mice. CCR2-deficient mice showed significantly increased amounts of circulating CCL2 compared with wild-type mice. Cxcr3(-/-) mice revealed increased levels of circulating and brain CXCL10 after experimental autoimmune encephalomyelitis (EAE) induction. CCR2-deficient peripheral blood and resident peritoneal cells exhibited reduced binding capacity and biologic responses to the CCR1 ligand CCL3, suggesting that elevated levels of CCR2 ligands had down-regulated CCR1. The results indicate that signaling chemokine receptors clear chemokines from circulation and tissues. These homeostatic functions of signaling chemokine receptors need to be integrated into safety and efficacy calculations when considering therapeutic receptor blockade.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1182/blood-2007-10-118497" target="_blank" rel="noreferrer noopener">10.1182/blood-2007-10-118497</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2008
Blood
blood-brain-barrier
Cardona A E
Cardona S M
ccx-ckr
central-nervous-system
cutting edge
d6
dendritic cell
experimental autoimmune encephalomyelitis
Hematology
Hu T
immune-response
in-vitro
Journal Article or Conference Abstract Publication
Liu L P
Mizutani M
Ransohoff R M
Sasse M E
Savarin C
sjogrens-syndrome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3-3
Issue
21
Volume
124
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Risk of Clostridium Difficile Infection in Leukemia and Lymphoma Patients
Publisher
An entity responsible for making the resource available
Blood
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-12
Subject
The topic of the resource
Hematology
Creator
An entity primarily responsible for making the resource
Abdelfatah M; Mohamed A; Rabih N; Kathleen E; Ala N; Richard W
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2014
Abdelfatah M
Ala N
Blood
Hematology
Journal Article or Conference Abstract Publication
Kathleen E
Mohamed A
Rabih N
Richard W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Issue
22
Volume
128
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Role of Vascular Smooth Muscle Kv 1.5 Channels in Coronary Metabolic Dilation
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-11
Subject
The topic of the resource
Blood; Cardiovascular System & Cardiology; Coronary circulation; flow; Heart failure; Ion channels; Smooth muscle
Creator
An entity primarily responsible for making the resource
Ohanyan V A; Luli J; Yin L Y; Logan S; Enrick M; Stevanov K; Kolz C L; Kmetz J; Bratz I; Chilian W M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
Blood
Bratz I
Cardiovascular System & Cardiology
Chilian W M
Circulation
Coronary Circulation
Enrick M
flow
Heart failure
Ion Channels
Journal Article
Kmetz J
Kolz C L
Logan S
Luli J
Ohanyan V A
smooth muscle
Stevanov K
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1469-7580.1998.19210013.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1469-7580.1998.19210013.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
13-23
Volume
192
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ultrastructural and cytochemical evaluation of sepsis-induced changes in the rat pulmonary intravascular mononuclear phagocytes
Publisher
An entity responsible for making the resource available
Journal of Anatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-01
Subject
The topic of the resource
acid-phosphatase; Anatomy & Morphology; Blood; cells; coagulation; differentiation; endotoxin; expression; host defence; human macrophage; lung uptake; monocytes; mononuclear phagocyte system; surface-coat
Creator
An entity primarily responsible for making the resource
Singh B; Doane K J; Niehaus G D
Description
An account of the resource
Sepsis stimulates an increase in the number and activity of mononuclear phagocytes in systemic host-defence organs. The present study was conducted to define the ultrastructural and cytochemical characteristics of the mononuclear phagocytes that sequester in the lung microvasculature of septic rats, Fourteen rats were challenged with a single intraperitoneal injection of saline (0.5 ml/100 g), E. coli (2 x 10(7)/100 g) or glucan (4 mg/100 g), and euthanased 2, 4, or 7 d later. The lungs were inflation fixed and processed for transmission electron microscopy. Cellular morphology was used to identify the intravascular mononuclear phagocytes and acid phosphatase (AcPase) expression was monitored as an index of cellular differentiation and activation. Control rats contained a limited number of monocytes in the pulmonary vasculature. In contrast, large numbers of activated mononuclear phagocytes were seen in the microvasculature within 48 h of treatment with either microbial product. The recruited pulmonary intravascular mononuclear phagocytes (PIMP) exhibited AcPase-reactive Golgi complexes, accumulation of secretory vesicles and other features of cell activation consistent with enhanced biosynthetic activity. Subsequent electron microscopy, conducted 4 and 7 d posttreatment, suggested that a progressive decline in the number and activity of PIMPs then occurred. In order to quantify the sepsis-induced accumulation of AcPase-positive PIMP, the experimental challenges were repeated in 11 rats and, 48 h later, tissue samples were evaluated by light microscopy for tartrate-insensitive acid phosphatase. Control rats exhibited 0.148 +/- 0.107 AcPase-positive PIMP/alveoli. E. coli and glucan challenged animals exhibited significant (P < 0.01) increases in AcPase-positive mononuclear phagocytes, with 0.782+/-0.073 and 0.636+/-0.170 PIMP/alveoli respectively, The results demonstrate that focal sepsis stimulates a significant, but transient, recruitment of activated mononuclear phagocytes into the rat pulmonary microvasculature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1469-7580.1998.19210013.x" target="_blank" rel="noreferrer noopener">10.1046/j.1469-7580.1998.19210013.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1998
acid-phosphatase
Anatomy & Morphology
Blood
Cells
coagulation
differentiation
Doane K J
endotoxin
expression
host defence
human macrophage
Journal Article
Journal of anatomy
lung uptake
monocytes
mononuclear phagocyte system
Niehaus G D
Singh B
surface-coat
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1164/ajrccm.158.3.9802031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1164/ajrccm.158.3.9802031</a>
Pages
760–768
Issue
3
Volume
158
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema.
Publisher
An entity responsible for making the resource available
American journal of respiratory and critical care medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-09
Subject
The topic of the resource
Adrenal Glands/*metabolism; Adrenalectomy; Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use; Adrenergic beta-Antagonists/therapeutic use; Amiloride/therapeutic use; Animal; Animals; Blood; Blood Pressure; Brain Diseases/chemically induced/*complications; Central Nervous System Agents/adverse effects; Cisterna Magna; Disease Models; Diuretics/therapeutic use; Dogs; Epinephrine/blood/*physiology/therapeutic use; Extravascular Lung Water/chemistry/*metabolism; Female; Hypertension; Injections; Male; Propanolamines/therapeutic use; Proteins/analysis; Pulmonary Alveoli/*metabolism; Pulmonary Artery; Pulmonary Edema/etiology/*metabolism/prevention & control; Pulmonary/prevention & control; Sodium Channel Blockers; Veratrine/adverse effects
Creator
An entity primarily responsible for making the resource
Lane S M; Maender K C; Awender N E; Maron M B
Description
An account of the resource
Case reports of neurogenic pulmonary edema (NPE) often indicate that the edema resolves quickly. Because plasma epinephrine concentration may be elevated in NPE, and epinephrine has been shown to increase the rate of alveolar liquid clearance (ALC), we determined if ALC was increased in a canine model of NPE produced by the intracisternal administration of veratrine. ALC was determined by instilling autologous plasma into a lower lung lobe and using the increase in instillate protein concentration after 4 h to calculate the volume of fluid cleared from the airspaces by mass balance. To prevent pulmonary hypertension and edema, which would confound the mass balance analysis, carotid arterial blood was allowed to drain into a reservoir as pulmonary arterial pressure started to rise after veratrine administration. ALC in animals administered veratrine (n = 6) was 30.4 +/- 1.6 (SE)% of the instilled volume compared with 14.1 +/- 2.1% observed in control animals. The increase in ALC could be inhibited by adrenalectomy, beta2-adrenergic blockade using ICI 118,551, or sodium channel blockade using amiloride and could be duplicated by infusing epinephrine to increase plasma epinephrine concentration to levels observed in NPE. These data indicate that the increased ALC was mediated by adrenal epinephrine and suggest that edema resolution in patients with NPE might be accelerated by endogenous epinephrine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1164/ajrccm.158.3.9802031" target="_blank" rel="noreferrer noopener">10.1164/ajrccm.158.3.9802031</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Adrenal Glands/*metabolism
Adrenalectomy
Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use
Adrenergic beta-Antagonists/therapeutic use
American journal of respiratory and critical care medicine
Amiloride/therapeutic use
Animal
Animals
Awender N E
Blood
Blood Pressure
Brain Diseases/chemically induced/*complications
Central Nervous System Agents/adverse effects
Cisterna Magna
Disease Models
Diuretics/therapeutic use
Dogs
Epinephrine/blood/*physiology/therapeutic use
Extravascular Lung Water/chemistry/*metabolism
Female
Hypertension
Injections
Lane S M
Maender K C
Male
Maron M B
Propanolamines/therapeutic use
Proteins/analysis
Pulmonary Alveoli/*metabolism
Pulmonary Artery
Pulmonary Edema/etiology/*metabolism/prevention & control
Pulmonary/prevention & control
Sodium Channel Blockers
Veratrine/adverse effects