1
40
10
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
595–599
Volume
1
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aspirin attenuation of alcohol-induced flushing and intoxication in Oriental and Occidental subjects.
Publisher
An entity responsible for making the resource available
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1905-6
Subject
The topic of the resource
Humans; Blood Pressure/drug effects; European Continental Ancestry Group; Heart Rate/drug effects; Asian Continental Ancestry Group; *Alcoholic Intoxication; Aspirin/*pharmacology; Ethanol/*antagonists & inhibitors/pharmacology; Flushing/*chemically induced; Skin Temperature/drug effects
Creator
An entity primarily responsible for making the resource
Truitt E B Jr; Gaynor C R; Mehl D L
Description
An account of the resource
Aspirin (ASA) was tested in a group of 8 Oriental and 3 Occidental subjects who were shown in a previous study to respond to small doses of ethanol (0.06-0.25 g/kg) with facial flushing. They were compared to a similar group of 11 non-flushing Occidental subjects following a larger ethanol dose (0.37 g/kg) to determine if similar effects could be produced in less sensitive individuals. Control tests of blood ethanol and acetaldehyde (AcH) levels (calculated from breath), facial and neck skin temperatures, body sway (Romberg test), blood pressure, heart rate and 10 Subjective High Assessment Scales (SHAS-Judd, 1977) were conducted before and at 15, 30, 60 and 90 minutes after drinking ethanol as vodka in orange juice. The tests were repeated one week later one hour after receiving 0.64 gm of ASA orally. ASA produced slight changes in the early absorption of ethanol and small decreases in AcH levels in the flushing and non-flushing groups. Facial flushing was markedly reduced in the flushing group, but was slightly increased in the non-flushing Occidentals. Body sway was reduced by ASA in both groups. An alcohol-induced increase in heart rate in the flushing group was reduced with no change in blood pressure. SHAS subjective parameters were widely variable, but indicated that ASA produced reduced sleepiness and earlier relaxation in the flushing group. It is concluded that ASA can block alcohol-induced facial flushing in sensitive subjects and also reduces body sway in the Romberg test and alters some subjective feelings of alcohol intoxication.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Alcoholic Intoxication
1987
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
Asian Continental Ancestry Group
Aspirin/*pharmacology
Blood Pressure/drug effects
Ethanol/*antagonists & inhibitors/pharmacology
European Continental Ancestry Group
Flushing/*chemically induced
Gaynor C R
Heart Rate/drug effects
Humans
Mehl D L
Skin Temperature/drug effects
Truitt E B Jr
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0026-2862(91)90034-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0026-2862(91)90034-9</a>
Pages
357–366
Issue
3
Volume
41
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of intracoronary infusion of histamine or compound 48/80 on coronary vascular permeability and myocardial fluid balance.
Publisher
An entity responsible for making the resource available
Microvascular research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-05
Subject
The topic of the resource
Female; Male; Animals; Dogs; Myocardium/*metabolism; Blood Pressure/drug effects; Coronary Circulation/*drug effects; Histamine/*administration & dosage; Lymph/drug effects; p-Methoxy-N-methylphenethylamine/*administration & dosage; Water-Electrolyte Balance/*drug effects; Infusions; Intra-Arterial
Creator
An entity primarily responsible for making the resource
Pilati C F
Description
An account of the resource
This study was undertaken to determine if coronary vascular permeability (CVP) increases and if myocardial edema develops in the canine heart after local exposure to histamine. Histamine (50 or 15 micrograms/min) or compound 48/80 (0.1-0.2 mg/kg) was infused into the left anterior descending coronary artery (LAD) of open-chest dogs, and changes in CVP were determined by comparing prenodal cardiac lymph flow (Q1) and lymph-to-plasma protein concentration ratio (C1/Cp) before and during histamine or compound 48/80 treatment. CVP increased in most, but not all, experiments with both doses of histamine as indicated by simultaneous increases in both Q1 and C1/Cp. The injection of compound 48/80 into the LAD of four dogs caused unequivocal increases in CVP in only one experiment. Compared with the effect of histamine on the forelimb, the average increases in Q1 and C1/Cp were not large with either histamine or compound 48/80, which suggests that the increases in CVP were relatively small. Moreover, edema did not develop. These results indicate that the coronary microvasculature of the intact dog heart is relatively insensitive to increases in permeability produced by histamine. Furthermore, the release of histamine from myocardial mast cells would not be expected to play a major role in the myocardial edema that develops under various pathological conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0026-2862(91)90034-9" target="_blank" rel="noreferrer noopener">10.1016/0026-2862(91)90034-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Blood Pressure/drug effects
Coronary Circulation/*drug effects
Dogs
Female
Histamine/*administration & dosage
Infusions
Intra-Arterial
Lymph/drug effects
Male
Microvascular research
Myocardium/*metabolism
p-Methoxy-N-methylphenethylamine/*administration & dosage
Pilati C F
Water-Electrolyte Balance/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3181/00379727-203-43579" target="_blank" rel="noreferrer noopener">http://doi.org/10.3181/00379727-203-43579</a>
Pages
100–107
Issue
1
Volume
203
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Persistent left ventricular dysfunction after cocaine treatment in rabbits.
Publisher
An entity responsible for making the resource available
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
Female; Male; Animals; Rabbits; Blood Pressure/drug effects; In Vitro Techniques; Stroke Volume/drug effects; Epinephrine/blood; Anesthesia; Norepinephrine/blood; Cocaine/*pharmacology; Consciousness; Heart/drug effects/physiology/*physiopathology; Ventricular Function; Dose-Response Relationship; Drug; General; Left/*drug effects
Creator
An entity primarily responsible for making the resource
Pilati C F; Espinal A R; Pukys T F
Description
An account of the resource
The present study was undertaken to determine whether the diminished cardiac performance associated with cocaine administration persists after the drug has been eliminated from the body. Cocaine (5 or 10 mg/kg iv) was administered to conscious (n = 7) or pentobarbital-anesthetized (n = 7) rabbits, respectively. Seven conscious and seven anesthetized control rabbits received the saline vehicle. Two and one-half hours later, the hearts were removed from the animals and perfused under cocaine-free conditions. Left ventricular (LV) contractility was evaluated by plotting steady-state LV systolic and diastolic pressures as a function of LV end-diastolic volume (preload). LV systolic performance was diminished in a dose-related manner in hearts isolated from cocaine-treated rabbits, but was statistically different from control only at the higher cocaine dose (P \textless 0.05). In a second set of experiments, hearts (n = 6) were isolated, and their LV function was evaluated before, during, and after cocaine exposure. In these experiments, cocaine was added to the perfusate in increments to produce concentrations of 5, 10, and 15 mg/liter. After LV function was evaluated at the highest cocaine dose, cocaine-free perfusion conditions were restored, and LV function was reevaluated. In these experiments, cocaine produced a dose-dependent decrease in LV function that readily reversed when cocaine-free perfusion was reinstated. We conclude that cocaine diminishes LV contractility, and that the diminished cardiac performance may not readily reverse after in vivo exposure. Moreover, the rapid restoration of cardiac performance after exposure to cocaine in vitro suggests that the mechanism operating in vivo involves more than a simple direct action on the myocyte. Catecholamine cardiotoxicity does not appear to be a primary factor.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3181/00379727-203-43579" target="_blank" rel="noreferrer noopener">10.3181/00379727-203-43579</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Anesthesia
Animals
Blood Pressure/drug effects
Cocaine/*pharmacology
Consciousness
Dose-Response Relationship
Drug
Epinephrine/blood
Espinal A R
Female
General
Heart/drug effects/physiology/*physiopathology
In Vitro Techniques
Left/*drug effects
Male
Norepinephrine/blood
Pilati C F
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Pukys T F
Rabbits
Stroke Volume/drug effects
Ventricular Function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0166560" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0166560</a>
Pages
e0166560–e0166560
Issue
11
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016
Subject
The topic of the resource
Male; Animals; Mice; Phosphorylation/drug effects; Signal Transduction/*drug effects; Rats; Cell Line; Proto-Oncogene Proteins c-akt/metabolism; Benzofurans/chemistry/*pharmacology; Blood Pressure/drug effects; GATA4 Transcription Factor/metabolism; Heart Failure/metabolism/*pathology; Heart Ventricles/diagnostic imaging; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Myocardium/metabolism/pathology; Drugs; Inbred C57BL; Animal; Disease Models; Myocytes; Aorta; Brain/blood; Natriuretic Peptide; Cardiac/cytology/drug effects/metabolism; Chinese Herbal/chemistry/pharmacology; Thoracic/surgery
Creator
An entity primarily responsible for making the resource
Yu Juan; Chen Renshan; Tan Yafang; Wu Jiashin; Qi Jianyong; Zhang Minzhou; Gu Weiwang
Description
An account of the resource
BACKGROUND: Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic acid B(SalB) is the major active component of Radix Salvia. This study investigated the mechanisms of action and effects of SalB on HF in an experimental mouse model of HF. METHODS: We created a mouse model of HF by inducing pressure overload with transverse aortic constriction(TAC) surgery for 2 weeks and compared among 4 study groups: SHAM group (n = 10), TAC group (n = 9), TAC+MET group (metprolol, positive drug treatment, n = 9) and TAC+SalB group (SalB, 240 mg*kg-1*day-1, n = 9). Echocardiography was used to evaluate the dynamic changes in cardiac structure and function in vivo. Plasma brain natriuretic peptide (BNP) concentration was detected by Elisa method. In addition, H9C2 rat cardiomyocytes were cultured and Western blot were implemented to evaluate the phosphorylation of ERK1/2, AKT, and protein expression of GATA4. RESULTS: SalB significantly inhibited the phosphorylation of Thr202/Tyr204 sites of ERK1/2, but not Ser473 site of AKT, subsequently inhibited protein expression of GATA4 and plasma BNP(P \textless 0.001), and then inhibited HF at 2 weeks after TAC surgery. CONCLUSIONS: Our data provide a mechanism of inactivating the ERK1/2/GATA4 signaling pathway for SalB inhibition of the TAC-induced HF.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0166560" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0166560</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Animal
Animals
Aorta
Benzofurans/chemistry/*pharmacology
Blood Pressure/drug effects
Brain/blood
Cardiac/cytology/drug effects/metabolism
Cell Line
Chen Renshan
Chinese Herbal/chemistry/pharmacology
Disease Models
Drugs
GATA4 Transcription Factor/metabolism
Gu Weiwang
Heart Failure/metabolism/*pathology
Heart Ventricles/diagnostic imaging
Inbred C57BL
Male
Mice
Mitogen-Activated Protein Kinase 1/metabolism
Mitogen-Activated Protein Kinase 3/metabolism
Myocardium/metabolism/pathology
Myocytes
Natriuretic Peptide
Phosphorylation/drug effects
PloS one
Proto-Oncogene Proteins c-akt/metabolism
Qi Jianyong
Rats
Signal Transduction/*drug effects
Tan Yafang
Thoracic/surgery
Wu Jiashin
Yu Juan
Zhang Minzhou
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/01.hyp.26.4.676" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/01.hyp.26.4.676</a>
Pages
676–683
Issue
4
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exercise attenuates cardiac autonomic regulation in hypertensive rats.
Publisher
An entity responsible for making the resource available
Hypertension (Dallas, Tex. : 1979)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
*Physical Exertion; Adrenergic Agents/pharmacology; Animals; Autonomic Nervous System/*physiopathology; Blood Pressure/drug effects; Cholinergic Agents/pharmacology; Heart Conduction System/*physiopathology; Heart Rate/drug effects; Hypertension/*physiopathology; Inbred SHR; Male; Nitroglycerin/pharmacology; Parasympathetic Nervous System/physiopathology; Phenylephrine/pharmacology; Rats; Sympathetic Nervous System/physiopathology; Time Factors
Creator
An entity primarily responsible for making the resource
Chen Y; Chandler M P; DiCarlo S E
Description
An account of the resource
Dynamic exercise may be used as a safe, therapeutic approach to reduce sympathetic nerve activity at rest and thus may be beneficial for individuals with hypertension. Therefore, we tested the hypothesis that a single bout of mild to moderate dynamic exercise would decrease cardiac sympathetic tonus at rest. We designed two experimental protocols to test this hypothesis in male spontaneously hypertensive rats. In protocol 1 (n = 6) cardiac sympathetic tonus and parasympathetic tonus were determined before and after a single bout of dynamic exercise. We developed protocol 2 (n = 5) to determine the component of the autonomic nervous system responsible for the postexercise reduction in heart rate. Rats were instrumented with catheters inserted into the descending aorta for measurements of arterial pressure, mean arterial pressure, and heart rate and into the jugular vein for infusion of drugs. A single bout of mild to moderate dynamic treadmill exercise (12 m/min, 10% grade for 42 +/- 1 minutes, representing approximately 74% to 79% of maximal heart rate) resulted in a postexercise reduction in mean arterial pressure (163 +/- 7 to 149 +/- 5 mm Hg; P \textless .05). Associated with the postexercise hypotension was a reduction in sympathetic and parasympathetic tonus (47 +/- 12% and 71 +/- 12%, respectively). The reduction in heart rate during the early recovery phase was due to a withdrawal of sympathetic tonus, because beta 1-adrenergic receptor blockade significantly enhanced the postexercise reduction in heart rate, and muscarinic-cholinergic receptor blockade did not affect the postexercise decrease in heart rate until 20 minutes after exercise.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/01.hyp.26.4.676" target="_blank" rel="noreferrer noopener">10.1161/01.hyp.26.4.676</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Exertion
1995
Adrenergic Agents/pharmacology
Animals
Autonomic Nervous System/*physiopathology
Blood Pressure/drug effects
Chandler M P
Chen Y
Cholinergic Agents/pharmacology
DiCarlo S E
Heart Conduction System/*physiopathology
Heart Rate/drug effects
Hypertension (Dallas, Tex. : 1979)
Hypertension/*physiopathology
Inbred SHR
Male
Nitroglycerin/pharmacology
Parasympathetic Nervous System/physiopathology
Phenylephrine/pharmacology
Rats
Sympathetic Nervous System/physiopathology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1991.71.3.1166" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1991.71.3.1166</a>
Pages
1166–1170
Issue
3
Volume
71
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hemodynamic basis for cocaine-induced pulmonary edema in dogs.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
Animals; Blood Pressure/drug effects; Cardiac Output/drug effects; Cocaine/*toxicity; Coronary Circulation/drug effects; Dogs; Female; Heart Rate/drug effects; Hemodynamics/*drug effects; Male; Pulmonary Circulation/drug effects; Pulmonary Edema/chemically induced/*physiopathology; Stroke Volume/drug effects; Vascular Resistance/drug effects
Creator
An entity primarily responsible for making the resource
Lang S A; Maron M B
Description
An account of the resource
We tested the hypothesis that cocaine-induced impairment of left ventricular function results in cardiogenic pulmonary edema. Mongrel dogs, anesthetized with alpha-chloralose, were injected with two doses of cocaine (5 mg/kg iv) 27 min apart. Cocaine produced transient decreases in aortic and left ventricular systolic pressures that were followed by increases exceeding control. As aortic pressure recovered, left ventricular end-diastolic, left atrial (Pla), pulmonary arterial (Ppa), and central venous pressures rose. Cardiac output and stroke volume were reduced when measured 4-5 min after cocaine administration. Peak Ppa and Pla were 31 +/- 5 (SE) mmHg (range 17-51 mmHg) and 26 +/- 5 mmHg (range 12-47 mmHg), respectively. Increases in extravascular lung water content (4.10 to 6.24 g H2O/g dry lung wt) developed in four animals in which Pla exceeded 30 mmHg. Analysis of left ventricular function curves revealed that cocaine depressed the inotropic state of the left ventricle. Cocaine-induced changes in hemodynamics spontaneously recovered and could be elicited again by the second dose of the drug. Our results show that cocaine-induced pulmonary hypertension, associated with decreased left ventricular function, produces pulmonary edema if pulmonary vascular pressures rise sufficiently.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1991.71.3.1166" target="_blank" rel="noreferrer noopener">10.1152/jappl.1991.71.3.1166</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Blood Pressure/drug effects
Cardiac Output/drug effects
Cocaine/*toxicity
Coronary Circulation/drug effects
Dogs
Female
Heart Rate/drug effects
Hemodynamics/*drug effects
Journal of applied physiology (Bethesda, Md. : 1985)
Lang S A
Male
Maron M B
Pulmonary Circulation/drug effects
Pulmonary Edema/chemically induced/*physiopathology
Stroke Volume/drug effects
Vascular Resistance/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpregu.1995.268.1.R40" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpregu.1995.268.1.R40</a>
Pages
R40–49
Issue
1
Volume
268
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
6-Ketoprostaglandin F1 alpha/metabolism; Analysis of Variance; Animals; Arginine Vasopressin/*pharmacology; Blood Pressure/drug effects; Desoxycorticosterone; Dietary; Dinoprostone/metabolism; Dose-Response Relationship; Drug; Female; Hypertension/chemically induced/*physiopathology; In Vitro Techniques; Male; Prostaglandins/analysis/*metabolism; Rats; Reference Values; Sex Characteristics; Sodium; Splanchnic Circulation/drug effects/*physiology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Stallone J N
Description
An account of the resource
Deoxycorticosterone acetate (DOCA)-salt hypertension develops to a greater extent in male (M) than in female (F) rats. To determine the role of the vasculature, reactivity to arginine vasopressin (AVP) and prostanoid output were examined in the isolated perfused mesenteric vasculature of hypertensive (HT) and normotensive-control (NTC) M and F rats after acute (1-wk) and chronic (4-wk)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpregu.1995.268.1.R40" target="_blank" rel="noreferrer noopener">10.1152/ajpregu.1995.268.1.R40</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
6-Ketoprostaglandin F1 alpha/metabolism
Analysis of Variance
Animals
Arginine Vasopressin/*pharmacology
Blood Pressure/drug effects
Desoxycorticosterone
Dietary
Dinoprostone/metabolism
Dose-Response Relationship
Drug
Female
Hypertension/chemically induced/*physiopathology
In Vitro Techniques
Male
Prostaglandins/analysis/*metabolism
Rats
Reference Values
Sex Characteristics
Sodium
Splanchnic Circulation/drug effects/*physiology
Sprague-Dawley
Stallone J N
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1993.265.4.H1184" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1993.265.4.H1184</a>
Pages
H1184–1188
Issue
4
Volume
265
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exercise enhances nitric oxide modulation of vascular response to phenylephrine.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-10
Subject
The topic of the resource
*Physical Exertion; Animals; Arginine/analogs & derivatives/pharmacology; Blood Flow Velocity; Blood Pressure/drug effects; Blood Vessels/*drug effects; Dose-Response Relationship; Drug; Female; Heart Rate/drug effects; Iliac Artery/drug effects/physiology; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide/antagonists & inhibitors/*physiology; Phenylephrine/*pharmacology; Rats; Sprague-Dawley; Time Factors; Vasoconstriction/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Patil R D; DiCarlo S E; Collins H L
Description
An account of the resource
The influence of the release of endothelium-derived nitric oxide (NO) on the vasoconstrictor response to phenylephrine (PE) was evaluated before and after a single bout of dynamic exercise. Each rat ran on a motor-driven treadmill at
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1993.265.4.H1184" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1993.265.4.H1184</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Exertion
1993
Animals
Arginine/analogs & derivatives/pharmacology
Blood Flow Velocity
Blood Pressure/drug effects
Blood Vessels/*drug effects
Collins H L
DiCarlo S E
Dose-Response Relationship
Drug
Female
Heart Rate/drug effects
Iliac Artery/drug effects/physiology
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide/antagonists & inhibitors/*physiology
Patil R D
Phenylephrine/*pharmacology
Rats
Sprague-Dawley
The American journal of physiology
Time Factors
Vasoconstriction/drug effects/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1993.265.4.H1179" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1993.265.4.H1179</a>
Pages
H1179–1183
Issue
4
Volume
265
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Attenuation of postexertional hypotension by cardiac afferent blockade.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-10
Subject
The topic of the resource
*Heart Arrest; *Physical Exertion; Afferent Pathways/physiology; Animals; Blood Pressure/drug effects; Efferent Pathways/physiology; Heart Rate/drug effects; Hypotension/*physiopathology; Inbred SHR; Induced; Pressoreceptors/drug effects; Procainamide/pharmacology; Rats; Reference Values
Creator
An entity primarily responsible for making the resource
Collins H L; DiCarlo S E
Description
An account of the resource
Naloxone eliminates postexertional hypotension (PEH) in human and animal models. The effect of naloxone on sympathetic activity during hemorrhage and generation of arterial baroreflex function curves can be stimulated by blockade of cardiac afferent receptors. We tested the hypothesis that cardiac afferent blockade would eliminate PEH in eight spontaneously hypertensive rats (SHR). Rats were instrumented with a Silastic-tipped catheter inserted into the pericardial space. Four weeks later, a Teflon catheter was placed in the descending aorta via the left common carotid artery for measurement of mean arterial pressure (MAP) and heart rate (HR). MAP and HR were examined before (preexercise) and after (postexercise) a single bout of dynamic treadmill exercise (9-12.0 m/min, 10-18% grade for 30-40 min) under three experimental conditions: control, cardiac efferent blockade, and combined cardiac efferent and afferent blockade. MAP significantly decreased (29 +/- 5 and 25.6 +/- 4 mmHg) in the control and cardiac efferent blockade conditions after exercise. However, when cardiac afferents were blocked, the hypotensive response to mild dynamic exercise was significantly attenuated (-6 +/- 3 mmHg). Thus blockade of cardiac afferents eliminated PEH in the SHR. These data suggest that inhibitory influence of cardiac afferents on the circulation may be enhanced after exercise.
Identifier
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<a href="http://doi.org/10.1152/ajpheart.1993.265.4.H1179" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1993.265.4.H1179</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Heart Arrest
*Physical Exertion
1993
Afferent Pathways/physiology
Animals
Blood Pressure/drug effects
Collins H L
DiCarlo S E
Efferent Pathways/physiology
Heart Rate/drug effects
Hypotension/*physiopathology
Inbred SHR
Induced
Pressoreceptors/drug effects
Procainamide/pharmacology
Rats
Reference Values
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1053/AJKD03400308" target="_blank" rel="noreferrer noopener">http://doi.org/10.1053/AJKD03400308</a>
Pages
308–314
Issue
2
Volume
34
Dublin Core
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Title
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Remission of nephrotic syndrome in type 1 diabetes: long-term follow-up of patients in the Captopril Study.
Publisher
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American journal of kidney diseases : the official journal of the National Kidney Foundation
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-08
Subject
The topic of the resource
Adult; Angiotensin-Converting Enzyme Inhibitors/*therapeutic use; Antihypertensive Agents/*therapeutic use; Blood Pressure/drug effects; Captopril/*therapeutic use; Chronic/etiology; Creatinine/blood; Diabetes Mellitus; Diabetic Nephropathies/*drug therapy/physiopathology; Disease Progression; Female; Follow-Up Studies; Humans; Kidney Failure; Male; Middle Aged; Nephrotic Syndrome/complications/*drug therapy/physiopathology; Prospective Studies; Proteinuria; Randomized Controlled Trials as Topic; Remission Induction; Type 1/*complications
Creator
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Wilmer W A; Hebert L A; Lewis E J; Rohde R D; Whittier F; Cattran D; Levey A S; Lewis J B; Spitalewitz S; Blumenthal S; Bain R P
Description
An account of the resource
In 1994, we reported a 3.4 +/- 0.8 year follow-up of the eight patients who experienced remission of nephrotic syndrome during the Collaborative Study Group-sponsored, multicenter trial of captopril therapy in patients with type 1 diabetes with nephropathy (Captopril Study). Of the 409 patients randomized to treatment on the Captopril Study, 108 had nephrotic syndrome (24-hour proteinuria \textgreater/= 3.5 g of protein) at baseline. Of these 108 patients, 8 experienced remission of nephrotic syndrome (proteinuria
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1053/AJKD03400308" target="_blank" rel="noreferrer noopener">10.1053/AJKD03400308</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Adult
American journal of kidney diseases : the official journal of the National Kidney Foundation
Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
Antihypertensive Agents/*therapeutic use
Bain R P
Blood Pressure/drug effects
Blumenthal S
Captopril/*therapeutic use
Cattran D
Chronic/etiology
Creatinine/blood
Department of Internal Medicine
Diabetes Mellitus
Diabetic Nephropathies/*drug therapy/physiopathology
Disease Progression
Female
Follow-Up Studies
Hebert L A
Humans
Kidney Failure
Levey A S
Lewis E J
Lewis J B
Male
Middle Aged
NEOMED College of Medicine
Nephrotic Syndrome/complications/*drug therapy/physiopathology
Prospective Studies
Proteinuria
Randomized Controlled Trials as Topic
Remission Induction
Rohde R D
Spitalewitz S
Type 1/*complications
Whittier F
Wilmer W A