1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/1061186X.2011.589435" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/1061186X.2011.589435</a>
Pages
837–845
Issue
9
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.
Publisher
An entity responsible for making the resource available
Journal of drug targeting
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Humans; Male; Animals; Mice; *Drug Delivery Systems; Rats; Cell Line; Nanoparticles; Permeability; Particle Size; Delayed-Action Preparations; Blood-Brain Barrier/metabolism; Adenosine Triphosphatases/metabolism; Brain Neoplasms/drug therapy; Cell Death/drug effects; Coumarins/administration & dosage/pharmacokinetics; Glioma/drug therapy/pathology; Glutathione/*chemistry; Microtubules/metabolism; Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology; Thiazoles/administration & dosage/pharmacokinetics; Tubulin/metabolism; Inbred C57BL; Tumor; ATP Binding Cassette Transporter; Antineoplastic Agents; Member 1/metabolism; Subfamily B; Phytogenic/administration & dosage/*pharmacokinetics/pharmacology
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner; Mbimba Thomas; Bui Thong; Harrison Kimberly; Sutariya Vijaykumar
Description
An account of the resource
Paclitaxel is not effective for treatment of brain cancers because it cannot cross the blood-brain barrier (BBB) due to efflux by P-glycoprotein (P-gp). In this work, glutathione-coated poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) of paclitaxel were developed for brain targeting for treatment of brain cancers. P-gp ATPase assay was used to evaluate the NP as potential substrates. The NP showed a particle size suitable for BBB permeation (particle size around 200 nm) and higher cellular uptake of the NP was demonstrated in RG2 cells. The
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/1061186X.2011.589435" target="_blank" rel="noreferrer noopener">10.3109/1061186X.2011.589435</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Drug Delivery Systems
2011
Adenosine Triphosphatases/metabolism
Animals
Antineoplastic Agents
ATP Binding Cassette Transporter
Blood-Brain Barrier/metabolism
Brain Neoplasms/drug therapy
Bui Thong
Cell Death/drug effects
Cell Line
Coumarins/administration & dosage/pharmacokinetics
Delayed-Action Preparations
Geldenhuys Werner
Glioma/drug therapy/pathology
Glutathione/*chemistry
Harrison Kimberly
Humans
Inbred C57BL
Journal of drug targeting
Male
Mbimba Thomas
Member 1/metabolism
Mice
Microtubules/metabolism
Nanoparticles
Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology
Particle Size
Permeability
Phytogenic/administration & dosage/*pharmacokinetics/pharmacology
Rats
Subfamily B
Sutariya Vijaykumar
Thiazoles/administration & dosage/pharmacokinetics
Tubulin/metabolism
Tumor
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/10611861003639796" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/10611861003639796</a>
Pages
665–674
Issue
9
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders.
Publisher
An entity responsible for making the resource available
Journal of drug targeting
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-11
Subject
The topic of the resource
Animals; Rats; Cell Line; Nanoparticles; Polylactic Acid-Polyglycolic Acid Copolymer; Particle Size; Delayed-Action Preparations; Antibodies; Polyethylene Glycols; Blood-Brain Barrier/metabolism; *Lactic Acid; *Polyglycolic Acid; Antioxidants/chemistry/*metabolism; Cross-Linking Reagents/chemistry; Cyclic N-Oxides/chemistry/*metabolism; Free Radical Scavengers/chemistry/*metabolism; Maleimides/chemistry; Spin Labels; Transferrin/*immunology; Tumor; Monoclonal/chemistry/*metabolism
Creator
An entity primarily responsible for making the resource
Carroll Richard T; Bhatia Deepak; Geldenhuys Werner; Bhatia Ruchi; Miladore Nicholas; Bishayee Anupam; Sutariya Vijaykumar
Description
An account of the resource
Brain-targeted Tempol-loaded poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) conjugated with a transferrin antibody (OX 26) were developed using the nanoprecipitation method. These NPs may have utility in treating neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Central to these diseases is an increased production of reactive oxygen and nitrogen species which may take part in the development of these conditions. As proof of principle, the NPs were loaded with Tempol, a free radical scavenger that has been shown to be protective against oxidative insults. To enhance the delivery of NPs to the central nervous system (CNS), we conjugated the transferrin receptor antibody covalently to PLGA NPs using the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/10611861003639796" target="_blank" rel="noreferrer noopener">10.3109/10611861003639796</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Lactic Acid
*Polyglycolic Acid
2010
Animals
Antibodies
Antioxidants/chemistry/*metabolism
Bhatia Deepak
Bhatia Ruchi
Bishayee Anupam
Blood-Brain Barrier/metabolism
Carroll Richard T
Cell Line
Cross-Linking Reagents/chemistry
Cyclic N-Oxides/chemistry/*metabolism
Delayed-Action Preparations
Free Radical Scavengers/chemistry/*metabolism
Geldenhuys Werner
Journal of drug targeting
Maleimides/chemistry
Miladore Nicholas
Monoclonal/chemistry/*metabolism
Nanoparticles
Particle Size
Polyethylene Glycols
Polylactic Acid-Polyglycolic Acid Copolymer
Rats
Spin Labels
Sutariya Vijaykumar
Transferrin/*immunology
Tumor
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2010.06.090" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2010.06.090</a>
Pages
4870–4877
Issue
16
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
3-D-QSAR and docking studies on the neuronal choline transporter.
Publisher
An entity responsible for making the resource available
Bioorganic & medicinal chemistry letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-08
Subject
The topic of the resource
Binding Sites; Blood-Brain Barrier/metabolism; Computer Simulation; Membrane Transport Proteins/*chemistry/metabolism; Models; Molecular; Neurons/*metabolism; Quantitative Structure-Activity Relationship; Quaternary Ammonium Compounds/chemistry
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Allen David D; Lockman Paul R
Description
An account of the resource
The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug delivery vector to the CNS, we investigated the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2010.06.090" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2010.06.090</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Allen David D
Binding Sites
Bioorganic & medicinal chemistry letters
Blood-Brain Barrier/metabolism
Computer Simulation
Geldenhuys Werner J
Lockman Paul R
Membrane Transport Proteins/*chemistry/metabolism
Models
Molecular
Neurons/*metabolism
Quantitative Structure-Activity Relationship
Quaternary Ammonium Compounds/chemistry