1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0">http://doi.org/10.1016/B978-0-12-818969-6.00020-0</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chapter 20 - Molecular insights into anatomy and physiology
Creator
An entity primarily responsible for making the resource
Cooper LN; Gorbunova V
Publisher
An entity responsible for making the resource available
The Bowhead Whale
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
Description
An account of the resource
Bowhead whales are some of the largest animals that occupy the Arctic Circle. Despite the challenges of living and giving birth in icy waters, having huge blubber stores, eating a fat-rich diet, and undergoing arduous migrations, bowheads achieved the longest known life span of mammals of 268 years. Their longevity is extended by fixed mutations that prevent DNA damage and cancer and through evolutionary modifications to their metabolism that compensate for an oxygen-poor environment. Recently, the bowhead genome and transcriptome libraries were made publicly available for study. Analyses suggest that their life span has been extended by evolutionary changes that result in the upregulation of DNA repair pathways. Molecular biologists are now undertaking laboratory experiments with whale samples that are informed by the bowhead genome and transcriptome to tackle questions that were inaccessible using classical model organisms such as rodents or fish. Biomedical researchers are also applying insights gained from research on bowheads into investigations of potential therapies for aging, senescence, and cancer. Moreover, researchers are using these results to inform our understanding of the evolutionary history of these traits. This chapter reviews the molecular basis for bowhead whale longevity and survival in their unique habitat and offers insights for further exploration into the molecular mechanisms that shape the extraordinary lives of these animals.
Identifier
An unambiguous reference to the resource within a given context
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0">http://doi.org/10.1016/B978-0-12-818969-6.00020-0</a></td>
</tr></tbody></table>
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2021
Balaena mysticetus
Blubber
bowhead whale
DNA
lipid
longevity
molecular evolution
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/B978-0-12-818969-6.00020-0</a>
Pages
299-307
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/B978-0-12-818969-6.00020-0</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chapter 20 - Molecular insights into anatomy and physiology
Publisher
An entity responsible for making the resource available
The Bowhead Whale
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-01-01
Subject
The topic of the resource
DNA; lipid; blubber; Bowhead whale; Balaena mysticetus; molecular evolution; longevity
Creator
An entity primarily responsible for making the resource
Cooper LN; Gorbunova V
Description
An account of the resource
Bowhead whales are some of the largest animals that occupy the Arctic Circle. Despite the challenges of living and giving birth in icy waters, having huge blubber stores, eating a fat-rich diet, and undergoing arduous migrations, bowheads achieved the longest known life span of mammals of 268 years. Their longevity is extended by fixed mutations that prevent DNA damage and cancer and through evolutionary modifications to their metabolism that compensate for an oxygen-poor environment. Recently, the bowhead genome and transcriptome libraries were made publicly available for study. Analyses suggest that their life span has been extended by evolutionary changes that result in the upregulation of DNA repair pathways. Molecular biologists are now undertaking laboratory experiments with whale samples that are informed by the bowhead genome and transcriptome to tackle questions that were inaccessible using classical model organisms such as rodents or fish. Biomedical researchers are also applying insights gained from research on bowheads into investigations of potential therapies for aging, senescence, and cancer. Moreover, researchers are using these results to inform our understanding of the evolutionary history of these traits. This chapter reviews the molecular basis for bowhead whale longevity and survival in their unique habitat and offers insights for further exploration into the molecular mechanisms that shape the extraordinary lives of these animals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/B978-0-12-818969-6.00020-0" target="_blank" rel="noreferrer noopener"></a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2021
Balaena mysticetus
Blubber
bowhead whale
Cooper LN
Department of Anatomy & Neurobiology
DNA
Gorbunova V
January 2021 List
journalArticle
lipid
longevity
molecular evolution
NEOEMD College of Medicine
The Bowhead Whale
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00360-016-1029-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00360-016-1029-6</a>
Pages
235–252
Issue
1
Volume
187
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.
Publisher
An entity responsible for making the resource available
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-01
Subject
The topic of the resource
*Lipid Metabolism; Adipose Tissue/*metabolism; Aging/metabolism; Amino Acid Sequence; Animals; Base Sequence; Beluga Whale/*physiology; Blubber; Body Temperature Regulation; Bowhead whale; Bowhead Whale/*physiology; Development; Female; Humans; Inbred C57BL; Leptin; Leptin/genetics; Leptin/genetics/metabolism; Lipase/genetics; Long-Evans; Male; Metabolic activity; Mice; Rats; Receptors; Seasons
Creator
An entity primarily responsible for making the resource
Ball H C; Londraville R L; Prokop J W; George John C; Suydam R S; Vinyard C; Thewissen J G M; Duff R J
Description
An account of the resource
The processes of lipid deposition and utilization, via the gene leptin (Lep), are poorly understood in taxa with varying degrees of adipose storage. This study examines how these systems may have adapted in marine aquatic environments inhabited by cetaceans. Bowhead (Balaena mysticetus) and beluga whales (Delphinapterus leucas) are ideal study animals-they possess large subcutaneous adipose stores (blubber) and undergo bi-annual migrations concurrent with variations in food availability. To answer long-standing questions regarding how (or if) energy and lipid utilization adapted to aquatic stressors, we quantified variations in gene transcripts critical to lipid metabolism related to season, age, and blubber depth. We predicted leptin tertiary structure conservation and assessed inter-specific variations in Lep transcript numbers between bowheads and other mammals. Our study is the first to identify seasonal and age-related variations in Lep and lipolysis in these cetaceans. While Lep transcripts and protein oscillate with season in adult bowheads reminiscent of hibernating mammals, transcript levels reach up to 10 times higher in bowheads than any other mammal. Data from immature bowheads are consistent with the hypothesis that short baleen inhibits efficient feeding. Lipolysis transcripts also indicate young Fall bowheads and those sampled during Spring months limit energy utilization. These novel data from rarely examined species expand the existing knowledge and offer unique insight into how the regulation of Lep and lipolysis has adapted to permit seasonal deposition and maintain vital blubber stores.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00360-016-1029-6" target="_blank" rel="noreferrer noopener">10.1007/s00360-016-1029-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Lipid Metabolism
2017
Adipose Tissue/*metabolism
Aging/metabolism
Amino Acid Sequence
Animals
Ball H C
Base Sequence
Beluga Whale/*physiology
Blubber
Body Temperature Regulation
bowhead whale
Bowhead Whale/*physiology
Department of Anatomy & Neurobiology
Department of Family & Community Medicine
development
Duff R J
Female
George John C
Humans
Inbred C57BL
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
leptin
Leptin/genetics
Leptin/genetics/metabolism
Lipase/genetics
Londraville R L
Long-Evans
Male
Metabolic activity
Mice
NEOMED College of Medicine
Prokop J W
Rats
Receptors
Seasons
Suydam R S
Thewissen J G M
Vinyard C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ar.23125" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ar.23125</a>
Pages
1416–1423
Issue
8
Volume
298
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Seasonal and Ontogenetic Variation in Subcutaneous Adipose Of the Bowhead Whale (Balaena mysticetus).
Publisher
An entity responsible for making the resource available
Anatomical record (Hoboken, N.J. : 2007)
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-08
Subject
The topic of the resource
*Biological Evolution; *Seasons; Adaptation; Adipocytes/*cytology; adipose; Age Factors; Animals; Autopsy; blubber; bowhead; Bowhead Whale/*anatomy & histology/psychology; Cell Size; Feeding Behavior; Female; Male; ontogeny; Physiological; seasonal variation; Subcutaneous Fat/*cytology
Creator
An entity primarily responsible for making the resource
Ball Hope C; Stavarz Madeline; Oldaker Jonathan; Usip Sharon; Londraville Richard L; George John C; Thewissen Johnannes G M; Duff Robert Joel
Description
An account of the resource
Cetacean evolution was shaped by an extraordinary land-to-sea transition in which the ancestors of whales became fully aquatic. As part of this transition, these mammals evolved unusually thick blubber which acts as a metabolic reservoir as well as an insulator and provides buoyancy and streamlining. This study describes blubber stratification and correlates it to seasonal variation, feeding patterns, and ontogeny in an arctic-adapted mysticete, the bowhead whale (Balaena mysticetus). Bowheads are unique among mammals for possessing the largest known blubber stores. We found that adipocyte numbers in bowheads, like other mammals, do not vary with season or feeding pattern but that adipocyte size and structural fiber densities do vary with blubber depth.
Identifier
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<a href="http://doi.org/10.1002/ar.23125" target="_blank" rel="noreferrer noopener">10.1002/ar.23125</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Biological Evolution
*Seasons
2015
Adaptation
Adipocytes/*cytology
adipose
Age Factors
Anatomical record (Hoboken, N.J. : 2007)
Animals
Autopsy
Ball Hope C
Blubber
bowhead
Bowhead Whale/*anatomy & histology/psychology
Cell Size
Department of Anatomy & Neurobiology
Duff Robert Joel
Feeding Behavior
Female
George John C
Londraville Richard L
Male
NEOMED College of Medicine
Oldaker Jonathan
ontogeny
Physiological
seasonal variation
Stavarz Madeline
Subcutaneous Fat/*cytology
Thewissen Johnannes G M
Usip Sharon