Browse Items · NEOMED Bibliography Database

Intraskeletal consistency in patterns of vascularity within bat limb bones

Bats are the only mammals to have achieved powered flight. A key innovation allowing for bats to conquer the skies was a forelimb modified into a flexible wing. The wing bones of bats are exceptionally long and dynamically bend with wingbeats. Bone…

Tags: 2022, Bone, Chiroptera, Cortical porosity, Micro-CT, synchrotron.

Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis

The aim of this review is to provide an updated review of the epigenetic factors involved in the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint disease characterized by chronic inflammation, ectopic bone formation…

Tags: 2022, Bone, Cartilage, Epigenetics, Methylation, Osteoarthritis.

Osteopathy in Complex Lymphatic Anomalies

Complex Lymphatic Anomalies (CLA) are lymphatic malformations with idiopathic bone and soft tissue involvement. The extent of the abnormal lymphatic presentation and boney invasion varies between subtypes of CLA. The etiology of these diseases has…

Tags: 2022, anomaly, Bone, lymphangiogenesis, lymphatic, osteolysis.

Intraskeletal Consistency in Patterns of Vascularity within Bat Limb Bones.

Bats are the only mammals to have achieved powered flight. A key innovation allowing for bats to conquer the skies was a forelimb modified into a flexible wing. The wing bones of bats are exceptionally long and dynamically bend with wingbeats. Bone…

Tags: 2021, Bone, Chiroptera, Cortical porosity, Micro-CT, Synchrotron

Intraskeletal Consistency in Patterns of Vascularity within Bat Limb Bones.

Bats are the only mammals to have achieved powered flight. A key innovation allowing for bats to conquer the skies was a forelimb modified into a flexible wing. The wing bones of bats are exceptionally long and dynamically bend with wingbeats. Bone …

Tags: 2021, Anatomical Record, Andronowski JM, Bone, Chiroptera, Cole Mary E, Cooper LN, Cortical porosity, Davis RA, Department of Anatomy & Neurobiology, Hieronymous TL, journalArticle, June 2021 List, Micro-CT, NEOMED College of Medicine, Synchrotron, Usher Logan R

Promoting bone health in children and adolescents following solid organ transplantation.

Solid organ transplantation in children and adolescents provides many benefits through improving critical organ function, including better growth, development, cardiovascular status, and quality of life. Unfortunately, bone status may be adversely…

Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (balaena mysticetus).

Bowhead whales are among the longest-lived mammals with an extreme lifespan of about 211 years. During the first 25 years of their lives, rib bones increase in mineral density and the medulla transitions from compact to trabecular bone. Molecular …

The role of miR-150 regulates bone cell differentiation and function.

BACKGROUND: mir-RNAs play a role in regulating bone homeostasis. In this study we assessed the functional role of mir-RNA 150 in bone homeostasis. We also assess the effects of miR-150 deficiency on osteoblast and osteoclast differentiation and…

Bone mineral density in adolescent urinary stone formers: is sex important?

Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This…

Knockdown Of Leptin A Expression Dramatically Alters Zebrafish Development

Using morpholino antisense oligonucleotide (MO) technology, we blocked leptin A or leptin receptor expression in embryonic zebrafish, and analyzed consequences of leptin A knock-down on fish development. Embryos injected with leptin A or leptin…

Collagen As A Scaffold For Biomimetic Mineralization Of Vertebrate Tissues

Collagen is a well known protein component that has the capacity to mineralize in a variety of vertebrate tissues. In its mineralized form, collagen potentially can be utilized as a biomimetic material for a variety of applications, including, for…

Vascular-mineral Spatial Correlation In The Calcifying Turkey Leg Tendon

Certain avian tendons are known to mineralize normally in a gender-related manner. These tendons have unique properties, as well as several features common to calcifying cartilage and bone in other vertebrate species. In cartilage and bone,…

Experiments With Osteoblasts Cultured Under Hypergravity Conditions

To understand further the role of gravity in osteoblast attachment, osteoblasts were subjected to hypergravity conditions in vitro. Scanning electron microscopy of all confluent coverslips from FPA units show that the number of attached osteoblasts…

Experiments With Osteoblasts Cultured Under Varying Orientations With Respect To The Gravity Vector

Substrate attachment is crucial for normal growth and differentiation of many cell types. To better understand the role of gravity in osteoblast attachment and growth in vitro, 17-day-old embryonic chick calvarial osteoblasts were subjected to…

The Functional Morphology Of The Anterior Masticatory Apparatus In Tree-gouging Marmosets (cebidae, Primates)

Although all genera of Callitrichinae feed on tree exudates, marmosets (Callithrix and Cebuella) use specialized anterior teeth to gouge holes in trees and actively stimulate exudate flow. Behavioral studies demonstrate that marmosets use large jaw…

Type Xxvii Collagen At The Transition Of Cartilage To Bone During Skeletogenesis

COL27A1 is a member of the collagen fibrillar gene family and is expressed in cartilaginous tissues including the anlage of endochondral bone. To begin to understand its role in skeletogenesis, the temporospatial distributions of its RNA message and…

Differences In Infrared Spectroscopic Data Of Connective Tissues In Transflectance And Transmittance Modes

Fourier transform infrared imaging spectroscopy (FT-IRIS) has been used extensively to characterize the composition and orientation of macromolecules in thin tissue sections. Earlier and current studies of normal and polarized FT-IRIS data have…

Age- And Genotype-dependence Of Bone Material Properties In The Osteogenesis Imperfecta Murine Model (oim)

Cortical mineralization of long bones was studied in collagen alpha2(I)-deficient mice (oim) used as a model for human osteogenesis imperfecta. Aspects of the age development of the mice were characterized by combining nanometer- to micrometer-scale…

Tuberculosis of the spine (Pott's disease) presenting as 'compression fractures'

Study design: Case reports and survey of literature. Objective: Case reports of two women with tuberculosis (TB) of the spine (Pott's disease) presenting with severe back pain and diagnosed as compression fracture are described. Physicians should…

Tags: 2002, Bone, compression, Dass B, Department of Family & Community Medicine, Diagnosis, Fracture, immunodeficiency-virus infection, Journal Article or Conference Abstract Publication, Management, NEOMED College of Medicine, Neurosciences & Neurology, Pott's disease, Puet T A, Rehabilitation, Spinal Cord, Tuberculosis, tuberculosis of spine, Watanakunakorn C

Evaluation of bioreactor-cultivated bone by magnetic resonance microscopy and FTIR micro spectroscopy

We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development…

BILATERAL BETA(2)-MICROGLOBULIN AMYLOIDOMAS OF THE BUTTOCKS IN A LONG-TERM HEMODIALYSIS PATIENT

Only two cases of beta(2)-microglobulin amyloid tumors involving the buttocks have been reported in the world literature. We report a case of bilateral buttock amyloid tumors with associated carpal tunnel syndrome and pathologic fracture involving…

Tags: 1994, Archives of pathology & laboratory medicine, beta-2-microglobulin amyloidosis, Biopsy, Bone, carpal-tunnel syndrome, Chandra R, Dialysis, Disease, Htwe M, involvement, Journal Article, Medical Laboratory Technology, origin, Pathology, Research & Experimental Medicine, Smithbehn J, Tom Y

Spine update - Lumbar interbody cages

Interbody cage devices, used to assist interbody fusion, are rapidly gaining popularity in the surgical management of chronic low back pain. This update provides a structural classification of commonly used devices and assesses them against a set of…

Pathological phalanges in a camarasaurid sauropod dinosaur and implications on behaviour

Several types of pathological bony overgrowth are known from various dinosaur taxa but, except for stress fractures, are rarely reported from appendicular elements. Herein we describe pathological manual and pedal phalanges of a camarasaurid sauropod…

Organization of apatite crystals in human woven bone

The organization of collagen fibrils differs in woven bone and lamellar bone, and it reflects certain aspects of the nature of the mineral crystals associated with them. In order to investigate the morphology and distribution of apatite crystals in…

Tags: 2003, apatite, Bone, Collagen, collagen fibril, Cui F Z, Endocrinology & Metabolism, Journal Article, Landis W J, leg tendons, microstructure, Su X, Sun K, Turkey, voltage electron-microscopy, woven bone

Molecular basis for elastic energy storage in mineralized tendon

Animals store elastic energy in leg and foot tendons during locomotion. In the turkey, much of the locomotive force generated by the gastrocnemius muscle is stored as elastic energy during tendon deformation. Little energy storage occurs within the…

Tags: 2001, Biochemistry & Molecular Biology, Biomacromolecules, Bone, Chemistry, collagen fibrils, dentin phosphophoryn, Department of Family & Community Medicine, electron-microscopic tomography, Freeman J W, Horvath I, in-vivo, Journal Article, Landis W J, matrix, NEOMED College of Medicine, Polymer Science, proteoglycan, Silver F H

Temperature regulates limb length in homeotherms by directly modulating cartilage growth

Allen's Rule documents a century-old biological observation that strong positive correlations exist among latitude, ambient temperature, and limb length in mammals. Although genetic selection for thermoregulatory adaptation is frequently presumed to…

Age estimation in bowhead whales using tympanic bulla histology and baleen isotopes

Tympanic bullae and baleen plates from bowhead whales of the Western Arctic population were examined. Growth layer groups (GLGs) in the involucrum of the tympanic bone were used to estimate age of the whales, and compared to stable isotope signatures…

Trabecular Bone Structure in the Mandibular Condyles of Gouging and Nongouging Platyrrhine Primates

The relationship between mandibular form and biomechanical function is a topic of significant interest to morphologists and paleontologists alike. Several previous studies have examined the morphology of the mandible in gouging and nongouging…

PARAVERTEBRALMASSES IN BLUE-TAILED MONITOR, VARANUS DORIANUS, INDICATIVE OF SOFT-TISSUE INFECTION WITH ASSOCIATED OSTEOMYELITIS

Paravertebral osseous masses in reptiles have been attributed to Paget's disease on the basis of histology. Histologically recognized mosaic architecture and cement lines, however, lack specificity. A Varanus dorianus with this condition was…

Non-destructive studies of tissue-engineered phalanges by magnetic resonance microscopy and X-ray microtomography

One of the intents of tissue engineering is to fabricate biological materials for the augmentation or replacement of impaired, damaged, or diseased human tissue. In this context, novel models of the human phalanges have been developed recently…

Cartilage calcification studied by proton nuclear magnetic resonance microscopy

A three-dimensional (3D) mineralizing culture system using hollow fiber bioreactors has been developed to study the early stages of endochondral ossification by proton nuclear magnetic resonance (NMR) microscopy. Chondrocytes harvested from the…

Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration.

Simvastatin (Sim) is a widely known drug in the treatment of hyperlipidemia, which has attracted so much attention in bone regeneration due to its potential osteoanabolic effect. However, repurposing of Sim in bone regeneration will require suitable…

Mutation in Osteoactivin Promotes Receptor Activator of NFkappaB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.

We previously reported on the importance of osteoactivin (OA/Gpnmb) in osteogenesis. In this study, we examined the role of OA in osteoclastogenesis, using mice with a nonsense mutation in the Gpnmb gene (D2J) and wild-type controls (D2J/Gpnmb(+)).…

The associations of 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms, and race with risk of incident fracture-related hospitalization: Twenty-year follow-up in a bi-ethnic cohort (the ARIC Study).

BACKGROUND: Deficient levels of 25-hydroxyvitamin D [25(OH)D] have been associated with increased fracture risk. Racial differences in fracture risk may be related to differences in bioavailable vitamin D due to single nucleotide polymorphism (SNP)…

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