1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
256-271
Issue
2
Volume
60
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Assessment of outcome following the use of recombinant human bone morphogenetic protein-2 for spinal fusion in the elderly population
Publisher
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Journal of Neurosurgical Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-06
Subject
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Allografts; anterior cervical-spine; Bone morphogenetic protein-2; clinical article; ectopic bone; Elderly; graft; lumbar interbody fusion; Neurosciences & Neurology; off-label use; older-adults; Outcome Assessment (Health Care); perioperative complications; rhBMP-2; rhBMP-2; Spinal fusion; Spine surgery; Surgery; Surgery
Creator
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Shweikeh F; Hanna G; Bloom L; Sayegh E T; Liu J; Acosta F L; Drazin D
Description
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INTRODUCTION: Although the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for spinal fusion has been fairly studied in the general population, relatively little research has been conducted on its use in the elderly patient demographic despite this population's growth. The authors sought to examine the clinical efficacy, complication rate, and cost-effectiveness of rhBMP-2 use in elderly patients undergoing spinal fusion surgery. EVIDENCE ACQUISITION: We conducted a systematic review of the published literature for elderly patients that underwent spinal fusion surgery with the use of rhBMP-2. A systematic search was performed utilizing the PUBMED and MEDLINE databases in order to identify all papers dealing with recombinant human Bone Morphogenic Protein-2 use in patients over the age of 60 years. EVIDENCE SYNTHESIS: Twenty-five papers were identified that met our inclusion criteria. While successful fusion, improvement in pain, and improved quality of life were encountered in elderly patients who were treated with fusions surgery along with rhBMP-2, there were several complications that were encountered including seroma formation, pleural effusions, and bone non-union. CONCLUSIONS: The literature demonstrated that BMP serves as a potent osteoinductive agent in the elderly with similar efficacy to bone auto graft. Although use of BMP showed mixed results and had higher initial costs, when taken into account with complication correction and costs, BMP usage appears to be more economically beneficial overall. Future studies are needed to clarify the clinical significance of the complications encountered in elderly patients treated with rhBMP-2. Future research can assist in developing recommendations which can minimize these risks in the elderly patient demographic.
Identifier
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n/a
Format
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Journal Article
2016
Acosta F L
Allografts
anterior cervical-spine
Bloom L
Bone morphogenetic protein-2
clinical article
Drazin D
ectopic bone
Elderly
graft
Hanna G
Journal Article
Journal of Neurosurgical Sciences
Liu J
lumbar interbody fusion
Neurosciences & Neurology
off-label use
older-adults
Outcome Assessment (Health Care)
perioperative complications
rhBMP-2
Sayegh E T
Shweikeh F
Spinal Fusion
spine surgery
Surgery
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1525-142X.2005.05048.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1525-142X.2005.05048.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
440-457
Issue
5
Volume
7
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity
Publisher
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Evolution & Development
Date
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2005
2005-09
Subject
The topic of the resource
ameloblast; Bone morphogenetic protein-2; dentition; Developmental Biology; differentiation; early tooth development; enamel knot; Evolutionary Biology; Genetics & Heredity; homeobox genes; in-vitro; missense mutation; molar teeth; murine; signaling pathways
Creator
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Plikus M V; Zeichner-David M; Mayer J A; Reyna J; Bringas P; Thewissen J G M; Snead M L; Chai Y; Chuong C M
Description
An account of the resource
During development and evolution, the morphology of ectodermal organs can be modulated so that an organism can adapt to different environments. We have proposed that morphoregulation can be achieved by simply tilting the balance of molecular activity. We test the principles by analyzing the effects of partial downregulation of Bmp signaling in oral and dental epithelia of the keratin 14-Noggin transgenic mouse. We observed a wide spectrum of tooth phenotypes. The dental formula changed from 1.0.0.3/1.0.0.3 to 1.0.0.2(1)/1.0.0.0. All mandibular and M3 maxillary molars were selectively lost because of the developmental block at the early bud stage. First and second maxillary molars were reduced in size, exhibited altered crown patterns, and failed to form multiple roots. In these mice, incisors were not transformed into molars. Histogenesis and differentiation of ameloblasts and odontoblasts in molars and incisors were abnormal. Lack of enamel caused misocclusion of incisors, leading to deformation and enlargement in size. Therefore, subtle differences in the level, distribution, and timing of signaling molecules can have major morphoregulatory consequences. Modulation of Bmp signaling exemplifies morphoregulation hypothesis: simple alteration of key signaling pathways can be used to transform a prototypical conical-shaped tooth into one with complex morphology. The involvement of related pathways and the implication of morphoregulation in tooth evolution are discussed.
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<a href="http://doi.org/10.1111/j.1525-142X.2005.05048.x" target="_blank" rel="noreferrer noopener">10.1111/j.1525-142X.2005.05048.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
ameloblast
Bone morphogenetic protein-2
Bringas P
Chai Y
Chuong C M
Dentition
Developmental Biology
differentiation
early tooth development
enamel knot
Evolution & Development
Evolutionary Biology
Genetics & Heredity
homeobox genes
in-vitro
Journal Article
Mayer J A
missense mutation
molar teeth
murine
Plikus M V
Reyna J
signaling pathways
Snead M L
Thewissen J G M
Zeichner-David M