1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1166-1172
Issue
6
Volume
16
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A pilot pharmacokinetic-pharmacodynamic study of benzodiazepine antagonism by flumazenil and aminophylline
Publisher
An entity responsible for making the resource available
Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-11
Subject
The topic of the resource
Pharmacology & Pharmacy; diazepam; midazolam; theophylline; volunteers
Creator
An entity primarily responsible for making the resource
Bonfiglio M F; FisherKatz L E; Saltis L M; Traeger S M; Martin B R; Nackes N A; Perkins T A
Description
An account of the resource
Study Objectives. To develop a pharmacokinetic-pharmacodynamic model using quantitative electroencephalographic (EEG) analysis to compare two separate benzodiazepine antagonists and generate data concerning response variability. Design. A pilot study using a randomized, blinded, crossover design. Setting. The Neurology Laboratory at the Akron City Hospital campus of SUMMA Health System. Patients. Four healthy volunteers completed the protocol. Interventions. Subjects received midazolam 0.1-0.2 mg/kg by intravenous bolus on 3 study days, separated by a minimum washout period of 1 week. Subjects participated in an initial open-label response phase followed by a randomized, crossover trial of each benzodiazepine antagonist. Measurements and Main Results. Venous blood samples were obtained to characterize the pharmacokinetics of all study compounds. The EEG parameter of total number of waves/second (recorded from FP1-F3 and FP2-F4 electrodes) in the frequency of 12-30 Hz was used to quantify effect. Flumazenil appeared to prolong the elimination half-life of midazolam significantly (p<0.05). Theophylline (aminophylline) also appeared to prolong the half-life of flumazenil (p<0.05). Despite considerable variability, flumazenil resulted in reversal of sedation at concentrations achieved by routine dosing. Resedation was apparent for all subjects following flumazenil reversal. Only partial reversal of sedation by theophylline was achieved by an aminophylline dose of 1-2 mg/kg. Conclusions. Flumazenil, was consistently effective in reversing sedation by midazolam at routinely recommended dosing. Further investigation of aminophylline as a reversal agent should use an estimated dose of 6-8 mg/kg aminophylline. To achieve adequate reversal, some patients may require aminophylline dosages that exceed safe clinical administration.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bonfiglio M F
Diazepam
FisherKatz L E
Journal Article or Conference Abstract Publication
Martin B R
midazolam
Nackes N A
Perkins T A
Pharmacology & Pharmacy
Pharmacotherapy
Saltis L M
theophylline
Traeger S M
volunteers
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/106002809202600105" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/106002809202600105</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
22-25
Issue
1
Volume
26
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
ANAPHYLACTOID REACTION TO INTRAVENOUS ACETYLCYSTEINE ASSOCIATED WITH ELECTROCARDIOGRAPHIC ABNORMALITIES
Publisher
An entity responsible for making the resource available
Annals of Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-01
Subject
The topic of the resource
Pharmacology & Pharmacy; n-acetylcysteine; adverse reactions; acetaminophen overdose
Creator
An entity primarily responsible for making the resource
Bonfiglio M F; Traeger S M; Hulisz D T; Martin B R
Description
An account of the resource
OBJECTIVE: To review the potential for anaphylactoid reactions to intravenously administered acetylcysteine when used in the treatment of acetaminophen overdose. This case is unique in that electrocardiographic changes, including ST segment depression and T-wave inversion were associated with the episode and complicated the diagnosis. DATA SOURCES: Reference articles and letters are identified in the text. DATA SYNTHESIS: Intravenous administration of acetylcysteine has been used in the treatment of acetaminophen overdose. This route may be considered in some clinical situations where oral therapy is complicated. Anaphylactoid reactions, including cutaneous eruptions, flushing, chest pain, tachycardia, and fever have been reported in up to three percent of patients receiving intravenous acetylcysteine. The nature of these reactions and evidence concerning their etiology suggest a histamine-release phenomenon. Response to intervention with antihistamines and the safety of further acetylcysteine administration are discussed. CONCLUSIONS: This case illustrates a variant anaphylactoid reaction to intravenously administered acetylcysteine and emphasizes the need for practitioners to consider the potential for these reactions prior to initiation of therapy and indicates appropriate treatment of these reactions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/106002809202600105" target="_blank" rel="noreferrer noopener">10.1177/106002809202600105</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
acetaminophen overdose
adverse reactions
Annals of Pharmacotherapy
Bonfiglio M F
Hulisz D T
Journal Article or Conference Abstract Publication
Martin B R
n-acetylcysteine
Pharmacology & Pharmacy
Traeger S M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00003246-199306000-00025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003246-199306000-00025</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
938-940
Issue
6
Volume
21
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CONTINUOUS-INFUSION OF PYRIDOSTIGMINE IN THE MANAGEMENT OF MYASTHENIC CRISIS
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-06
Subject
The topic of the resource
cholinergic; cholinesterase inhibitors; compounds; edrophonium; General & Internal Medicine; gravis; injections; intravenous; kinetics; myasthenia gravis; neostigmine; neuromuscular diseases; ocular motility disorders; pyridinium; pyridostigmine bromide; receptors; ventilatory weaning
Creator
An entity primarily responsible for making the resource
Saltis L M; Martin B R; Traeger S M; Bonfiglio M F
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003246-199306000-00025" target="_blank" rel="noreferrer noopener">10.1097/00003246-199306000-00025</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1993
Bonfiglio M F
cholinergic
cholinesterase inhibitors
compounds
Critical care medicine
edrophonium
General & Internal Medicine
gravis
Injections
Intravenous
Journal Article
Kinetics
Martin B R
myasthenia gravis
neostigmine
neuromuscular diseases
ocular motility disorders
pyridinium
pyridostigmine bromide
Receptors
Saltis L M
Traeger S M
ventilatory weaning
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/clinids/21.6.1504" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/clinids/21.6.1504</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1504-1506
Issue
6
Volume
21
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Seizures associated with ofloxacin therapy
Publisher
An entity responsible for making the resource available
Clinical Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
Immunology; Infectious Diseases; intravenous ofloxacin; Microbiology
Creator
An entity primarily responsible for making the resource
Traeger S M; Bonfiglio M F; Wilson J A; Martin B R; Nackes N A
Description
An account of the resource
We describe four patients who had seizures while receiving ofloxacin; no other causes were evident. Common factors among all patients included advanced age and use of a high-dose regimen. The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor, Other potentially related factors included electrolyte abnormalities and prior neurological insult. Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/clinids/21.6.1504" target="_blank" rel="noreferrer noopener">10.1093/clinids/21.6.1504</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1995
Bonfiglio M F
Clinical Infectious Diseases
Immunology
Infectious Diseases
intravenous ofloxacin
Journal Article
Martin B R
Microbiology
Nackes N A
Traeger S M
Wilson J A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/106002809502900901" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/106002809502900901</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
835-842
Issue
9
Volume
29
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
THROMBOCYTOPENIA IN INTENSIVE-CARE PATIENTS - A COMPREHENSIVE ANALYSIS OF RISK-FACTORS IN 314 PATIENTS
Publisher
An entity responsible for making the resource available
Annals of Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-09
Subject
The topic of the resource
vancomycin; Pharmacology & Pharmacy; antibodies; respiratory-distress syndrome; septicemia; heparin-associated thrombocytopenia; intravascular coagulation
Creator
An entity primarily responsible for making the resource
Bonfiglio M F; Traeger S M; Kier K L; Martin B R; Hulisz D T; Verbeck S R
Description
An account of the resource
OBJECTIVE: To define the incidence and severity of thrombocytopenia in a mixed medical-surgical population of critically ill patients and to examine factors that may be related to the development of thrombocytopenia. DESIGN: Retrospective chart review of 314 critically ill patients requiring at least 3 days of critical care. SETTING: A 17-bed combined medical-surgical intensive care unit (ICU) in a 560-bed tertiary care community hospital. PATIENTS: Medical and surgical patients admitted to the ICU. INTERVENTIONS: All medical records over the duration of the ICU stay were reviewed, All scheduled medications, including dosage and start/stop dates, were recorded. All platelet counts, placement of pulmonary artery catheters, liver function test results, and admission serum creatinine concentrations were collected. MEASUREMENT AND MAIN RESULTS: Thrombocytopenia (platelet count less than 200 x 10(9)/L) was observed frequently, but rarely reached a severe stage (7 patients). No single diagnostic category was significantly associated with thrombocytopenia alone, although the combination of sepsis syndrome/septic shock and respiratory failure was strongly correlated (p < 0.0001) with thrombocytopenia. Liver function abnormalities were correlated strongly with thrombocytopenia, and the majority of patients (5 of 7) with severe thrombocytopenia (less than 20 x 10(9)/L) were found to have concurrent severe alterations in liver function test results. Pulmonary artery catheter placement and heparin exposure were associated strongly with thrombocytopenia (p < 0.0001). Drug therapies that were correlated with thrombocytopenia included heparin and vancomycin (p < 0.05). Hemodynamic instability was correlated strongly with the presence and severity of thrombocytopenia. In a stepwise linear regression model, the admission platelet count accounted for the largest proportion of the variance (43%), followed by hemodynamic instability (8%) and the requirement for inotropic agents (2%). CONCLUSIONS: Thrombocytopenia in the critically ill occurs frequently, rarely reaches severely depressed concentrations, and primarily represents a manifestation of disease processes initiated prior to admission. Hemodynamic instability and/or heparin exposure appear to be the strongest identifiable correlates with thrombocytopenia. Although these may cause infrequent isolated cases, other specific drug causes of thrombocytopenia are not responsible for the majority of cases of thrombocytopenia in the critically ill.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/106002809502900901" target="_blank" rel="noreferrer noopener">10.1177/106002809502900901</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
Annals of Pharmacotherapy
Antibodies
Bonfiglio M F
heparin-associated thrombocytopenia
Hulisz D T
intravascular coagulation
Journal Article or Conference Abstract Publication
Kier K L
Martin B R
Pharmacology & Pharmacy
respiratory-distress syndrome
septicemia
Traeger S M
vancomycin
Verbeck S R