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Carbapenem-Resistant Enterobacteriaceae Infections in Patients on Renal Replacement Therapy.

Background: Patients on chronic intermittent renal replacement therapy (RRT) are at risk for infection with carbapenem-resistant Enterobacteriaceae (CRE). However, the impact of RRT on outcomes after CRE infections remains to be defined. Here we…

The Pitt Bacteremia Score Predicts Mortality in Non-Bacteremic Infections.

Background: Predicting mortality risk in patients is important in research settings. The Pitt bacteremia score (PBS) is commonly used as a predictor of early mortality risk in patients with bloodstream infections (BSI). Here, we determined whether…

A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.

BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on…

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE)…

Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE)…

508. Gentamicin Non-susceptibility is Associated with Persistence of Carbapenem-Resistant Klebsiella pneumoniae in the Urinary Tract.

Background Urinary tract infection (UTI) is the most common clinical manifestation of carbapenem-resistant Klebsiella pneumoniae (CR Kp). Persistent CR Kp bacteriuria is associated with the spread of CR Kp and antibiotic overuse. Risk factors for…

Tags: 2019, amikacin, antibiotic overuse, antimicrobial susceptibility, bacteriuria, Bonomo Robert A, carbapenem resistance, carbapenem-resistant Enterobacteriaceae, CENTERS for Disease Control & Prevention (U.S.), Cleveland Clinic Akron General Hospital, Cober Eric, Department of Internal Medicine, Disclosure, Doi Yohei, Duin David van, Gentamicin, gentamicin sulfate (usp), gentamicins, health care safety, health care systems, Henderson Heather I, hospital admission, Journal Article, Kaye Keith S, Klebsiella pneumonia, Laboratory, Luterbach Courtney L, Midwestern United States, NEOMED College of Medicine, North Carolina, November 2019 Update, Open forum infectious diseases, Persistence, rales, Richter Sandra S, Salata Robert A, signs and symptoms, Trimethoprim-Sulfamethoxazole Combination, URINARY organs, urinary tract, Urinary Tract Infections, Urine, urine culture, Watkins Richard R

Ceftolozane/Tazobactam vs Polymyxin or Aminoglycoside-based Regimens for the Treatment of Drug-resistant Pseudomonas Aeruginosa

BACKGROUND: Ceftolozane/tazobactam is a novel cephalosporin/beta-lactamase inhibitor combination that often retains activity against resistant Pseudomonas aeruginosa. The comparative safety and efficacy vs polymyxins or aminoglycosides in this…

Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Background: Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide.…

Tags: *beta-Lactam Resistance, *carbapenem-resistant Enterobacteriaceae, *Colistin, *Klebsiella pneumoniae, *mortality, *ST258, 2017, Aged, Anti-Bacterial Agents/pharmacology/*therapeutic use, beta-Lactamases/genetics, Bonomo Robert A, Carbapenems/pharmacology/therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Cober Eric, Colistin/pharmacology/*therapeutic use, Comorbidity, Department of Internal Medicine, Doi Yohei, Domitrovic T Nicholas, Evans Scott, Female, Fowler Vance G Jr, Hujer Andrea M, Hujer Kristine M, Humans, Kalayjian Robert C, Kaplan-Meier Estimate, Kaye Keith S, Klebsiella Infections/diagnosis/*drug therapy/*microbiology/mortality, Klebsiella pneumoniae/classification/*drug effects/genetics, Male, Marshall Steve, Microbial Sensitivity Tests, Middle Aged, NEOMED College of Medicine, Perez Federico, Phylogeny, Proportional Hazards Models, Richter Sandra S, Rojas Laura J, Rudin Susan D, Salata Robert A, Salim Madiha, van Duin David, Watkins Richard R

Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae.

Background: The efficacy of ceftazidime-avibactam-a cephalosporin-beta-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CRE)-compared with colistin…

Overview: Global and Local Impact of Antibiotic Resistance.

The rapid and ongoing spread of antibiotic resistance poses a serious threat to global public health. The indiscriminant use of antibiotics in agriculture and human medicine along with increasingly connected societies has fueled the distribution of…

Tags: *Agriculture, *Antibiotic resistance, *Bacterial Infections/drug therapy/microbiology/prevention & control, *Drug Resistance, *Global Health, *Infections, *Public health, 2016, Agriculture, Anti-Bacterial Agents/pharmacology/therapeutic use, Bacteria/drug effects, Bacterial, Bonomo Robert A, Department of Internal Medicine, Humans, Infectious disease clinics of North America, NEOMED College of Medicine, United States, Watkins Richard R

Increasing prevalence of carbapenem-resistant Enterobacteriaceae and strategies to avert a looming crisis.

Tags: 2013, Antibiotics – Therapeutic Use, Bonomo Robert A, Carbapenems – Therapeutic Use, Department of Internal Medicine, Drug Resistance, Early Diagnosis, Enterobacteriaceae – Drug Effects, Enterobacteriaceae – Physiology, Enterobacteriaceae Infections – Diagnosis, Enterobacteriaceae Infections – Drug Therapy, Enterobacteriaceae Infections – Microbiology, Expert review of anti-infective therapy, Microbial, NEOMED College of Medicine, Watkins Richard R

Tags: 2018, Bonomo Robert A, Burdette Steven D, Ceftaroline, Department of Internal Medicine, Discitis, epidural abscess, Haller Nairmeen Awad, Horattas Sophia, Journal of global antimicrobial resistance, Mangira Caroline, MRSA, NEOMED College of Medicine, Salata Robert A, Vertebral osteomyelitis, Watkins Richard R, Yendewa George

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