1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Pages 36–42 Issue 6 Volume 3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease. Publisher An entity responsible for making the resource available Journal of Gender-Specific Medicine Date A point or period of time associated with an event in the lifecycle of the resource 2000 2000-09 Subject The topic of the resource Female; Male; Sex Factors; Postmenopause; Gender Specific Care; Toxins; Basal Ganglia – Pathology; Brain Stem – Pathology; Basal Ganglia – Physiopathology; Brain Stem – Physiopathology; Dopamine – Metabolism; Estrogens – Pharmacodynamics; Parkinson Disease – Metabolism; Parkinson Disease – Pathology; Parkinson Disease – Physiopathology Creator An entity primarily responsible for making the resource Dluzen D E; McDermott J L Description An account of the resource This article describes the progression of steps followed to demonstrate a gender difference associated with Parkinson's disease (PD) and to gain an understanding of the basis, mechanisms, and implications of this gender specificity. First, a review of the literature on PD shows a greater incidence in men. Next, data are presented from a series of laboratory studies in animal models of PD that suggest a basis for this gender difference: estrogen appears to act as a neuroprotectant of the striatal dopaminergic system. One mechanism for this effect may be that estrogen inhibits the uptake of neurotoxins capable of producing degeneration within dopaminergic neurons. Finally, some of the potential neurologic implications of manipulating estrogen in premenopausal and postmenopausal women are considered. Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2000 Basal Ganglia – Pathology Basal Ganglia – Physiopathology Brain Stem – Pathology Brain Stem – Physiopathology Dluzen D E Dopamine – Metabolism Estrogens – Pharmacodynamics Female Gender Specific Care Journal of Gender-Specific Medicine Male McDermott J L Parkinson Disease – Metabolism Parkinson Disease – Pathology Parkinson Disease – Physiopathology Postmenopause Sex Factors Toxins