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Text
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Pages
213–220
Issue
1
Volume
71
Dublin Core
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Title
A name given to the resource
Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin.
Publisher
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Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-07
Subject
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Humans; Animals; Mice; Signal Transduction/drug effects/*physiology; Phosphorylation; Mitogen-Activated Protein Kinase 1/metabolism; Antineoplastic Agents/pharmacology; Type C Phospholipases/metabolism; Cell Differentiation/drug effects; Neuroprotective Agents/*metabolism; Neuroblastoma; alpha-Macroglobulins/*pharmacology; *Mitogen-Activated Protein Kinases; 3T3 Cells/chemistry/cytology/enzymology; Brain-Derived Neurotrophic Factor/pharmacology; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Isoenzymes/metabolism; Mitogen-Activated Protein Kinase 3; Nerve Growth Factors/pharmacology; Neurotrophin 3; Phospholipase C gamma; Receptor Protein-Tyrosine Kinases/*metabolism; Serotonin/metabolism; Tretinoin/pharmacology; Ciliary Neurotrophic Factor; Receptors; Receptor; Tumor Cells; Cultured/chemistry/cytology/enzymology; Nerve Growth Factor/*metabolism; trkC
Creator
An entity primarily responsible for making the resource
Hu Y Q; Koo P H
Description
An account of the resource
Monoamine-activated alpha2-macroglobulin (alpha2M) was shown to reduce the dopamine concentration in corpus striatum of adult rat brains and inhibit other neuronal functions in vivo and in vitro. As brain-derived neurotrophic factor, neurotrophin-4, and neurotrophin-3 are important neurotrophic factors for dopaminergic neurons, the effect of monoamine-activated alpha2M on signal transduction by trkB and trkC was investigated. The results show that monoamine-activated alpha2M binds to trkB and inhibits brain-derived neurotrophic factor/neurotrophin-4-promoted autophosphorylation of trkB in a dose-dependent manner in both trkB-expressing NIH3T3 (NIH3T3-trkB) and human neuroblastoma
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Mitogen-Activated Protein Kinases
1998
3T3 Cells/chemistry/cytology/enzymology
alpha-Macroglobulins/*pharmacology
Animals
Antineoplastic Agents/pharmacology
Brain-Derived Neurotrophic Factor/pharmacology
Calcium-Calmodulin-Dependent Protein Kinases/metabolism
Cell Differentiation/drug effects
Ciliary Neurotrophic Factor
Cultured/chemistry/cytology/enzymology
Hu Y Q
Humans
Isoenzymes/metabolism
Journal of neurochemistry
Koo P H
Mice
Mitogen-Activated Protein Kinase 1/metabolism
Mitogen-Activated Protein Kinase 3
Nerve Growth Factor/*metabolism
Nerve Growth Factors/pharmacology
Neuroblastoma
Neuroprotective Agents/*metabolism
Neurotrophin 3
Phospholipase C gamma
Phosphorylation
Receptor
Receptor Protein-Tyrosine Kinases/*metabolism
Receptors
Serotonin/metabolism
Signal Transduction/drug effects/*physiology
Tretinoin/pharmacology
trkC
Tumor Cells
Type C Phospholipases/metabolism