1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/1568009617666161121123948" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/1568009617666161121123948</a>
Pages
479–485
Issue
5
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.
Publisher
An entity responsible for making the resource available
Current cancer drug targets
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-7
Subject
The topic of the resource
Female; Humans; Animals; Mice; Apoptosis; Cell Line; ADME; Antineoplastic Agents/*therapeutic use; brain cancer; Brain Neoplasms/*drug therapy/pathology/*secondary; Breast Neoplasms/*pathology; chemotherapy; CNS; distribution; drug discovery; Drug resistance; Tumor
Creator
An entity primarily responsible for making the resource
Venishetty Vinay K; Geldenhuys Werner J; Terell-Hall Tori B; Griffith Jessica I G; Sondag Gregory R; Safadi Fayez F; Lockman Paul R
Description
An account of the resource
BACKGROUND: Brain cancer from metastasized breast cancer has a high mortality rate in women. The treatment of lesions is hampered in large part by the blood-brain barrier (BBB), which prevents adequate distribution of anti-cancer compounds to brain metastases. METHOD: In this study we used a novel screening method to identify candidate molecules that are well-suited to utilizing the BBB choline transporter for distribution into the brain parenchyma. RESULTS: From our screen we identified two compounds, Ch-1 and Ch-2 that were able to reduce the brain tumor burden in a murine mouse model of brain metastasis of breast cancer. These compounds also significantly increased the survival of mice by more than 10 days. Mechanistic studies indicated that Ch-1 is able to prevent the activation of the pro-survival mitogen-activated kinases (MAPKs) by osteoactivin (OA; Glycoprotein nonmetastatic melanoma protein B GPNMB). CONCLUSION: The results from this study show that nutrient transporter virtual screening is a viable novel alternative to traditional drug screening programs to identify anti-cancer compounds for the treatment of brain cancers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/1568009617666161121123948" target="_blank" rel="noreferrer noopener">10.2174/1568009617666161121123948</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
ADME
Animals
Antineoplastic Agents/*therapeutic use
Apoptosis
Brain cancer
Brain Neoplasms/*drug therapy/pathology/*secondary
Breast Neoplasms/*pathology
Cell Line
Chemotherapy
CNS
Current cancer drug targets
Department of Anatomy & Neurobiology
distribution
Drug Discovery
Drug Resistance
Female
Geldenhuys Werner J
Griffith Jessica I G
Humans
Lockman Paul R
Mice
NEOMED College of Medicine
Safadi Fayez F
Sondag Gregory R
Terell-Hall Tori B
Tumor
Venishetty Vinay K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.compbiomed.2003.12.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.compbiomed.2003.12.006</a>
Pages
91–101
Issue
2
Volume
35
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The relation of breast cancer staging to screening protocol compliance: a computer simulation study.
Publisher
An entity responsible for making the resource available
Computers in biology and medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-02
Subject
The topic of the resource
*Computer Simulation; *Models; *Patient Compliance; Adult; Breast Neoplasms/*pathology; Clinical Protocols; Female; Humans; Mammography; Mass Screening/standards; Middle Aged; Neoplasm Staging/*methods; Theoretical
Creator
An entity primarily responsible for making the resource
Castro Frank; Carter Kimbroe J; Kessler Edward; Erickson Barbara A; Kseibi Samer A
Description
An account of the resource
A computer model based on relational database techniques was used to analyze the relationship between staging and population compliance to a breast cancer screening protocol. Stage distribution data permitted estimates of compliance to the protocol. This relationship followed the equation y=5.83e-2.44x where y was compliance and x was disease stage. Application of this equation to SEER and NCDB data estimated that the levels of compliance never exceeded 16 percent. Results indicated increasing clinical Stage IV disease as population compliance decreased. As the clinical staging increased there was increased sub-clinical Stage IV disease. With regular screening, simulation suggested that mortality would decrease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.compbiomed.2003.12.006" target="_blank" rel="noreferrer noopener">10.1016/j.compbiomed.2003.12.006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Computer Simulation
*Models
*Patient Compliance
2005
Adult
Breast Neoplasms/*pathology
Carter Kimbroe J
Castro Frank
Clinical Protocols
Computers in biology and medicine
Erickson Barbara A
Female
Humans
Kessler Edward
Kseibi Samer A
Mammography
Mass Screening/standards
Middle Aged
Neoplasm Staging/*methods
Theoretical