1
40
23
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
51-52
Issue
10
Volume
23
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Flesh-eating Bacteria
Publisher
An entity responsible for making the resource available
Physician and Sportsmedicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
General & Internal Medicine; Orthopedics; Sport Sciences
Creator
An entity primarily responsible for making the resource
Jain R; Bredle D L; Helms S E; Brodell R T
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
Bredle D L
Brodell R T
General & Internal Medicine
Helms S E
Jain R
Journal Article or Conference Abstract Publication
Orthopedics
Physician and Sportsmedicine
Sport Sciences
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A371-A371
Issue
3
Volume
42
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Predicted Vs Measured Energy-expenditure In Critically Ill Mechanically Ventilated Patients
Publisher
An entity responsible for making the resource available
Clinical Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-10
Subject
The topic of the resource
Nutrition & Dietetics; Research & Experimental Medicine
Creator
An entity primarily responsible for making the resource
Heiselman D E; Beckner J; Black L; Bredle D L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
Beckner J
Black L
Bredle D L
Clinical Research
Heiselman D E
Journal Article or Conference Abstract Publication
Nutrition & Dietetics
Research & Experimental Medicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.109.3.756" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.109.3.756</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
756-760
Issue
3
Volume
109
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopexamine Hydrochloride In Septic Shock
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
consumption; dobutamine; dopexamine hydrochloride; endotoxic dogs; General & Internal Medicine; heart failure; infusion; inotropic support; lactate; muscle; O-2 transport; O-2 uptake; optimal values; oxygen delivery; Respiratory System; respiratory-distress syndrome; sepsis; septic shock; tissue oxygenation; volume support
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Meierhellmann A; Wallenfang G; Bredle D L
Description
An account of the resource
Objective: To test whether dopexamine hydrochloride, by its beta(2)-adrenoceptor and dopaminergic 1 (DA(1)) and dopaminergic 2 (DA(2)) agonistic properties, can improve oxygen consumption (V over dot O-2) in hyperdynamic patients with septic shock. Design: Prospective, single-cohort study. Setting: ICU, university hospital. Patients: Twenty-nine postoperative, hemodynamically stabilized, hyperdynamic patients with septic shock. Interventions: Short-term application (30 min) of dopexamine hydrochloride at a dose of 2 mu g/kg/min. Measurements: Complete hemodynamic profile with O-2 transport-related variables at baseline, 30 min after starting the dopexamine infusion, and 30 min after stopping the infusion. Main results: The dopexamine infusion resulted in significant increases in cardiac index (17%) (p<0.001) and O-2 delivery (DO2) (16%) (p<0.001), V over dot O-2 increased slightly but significantly about 4% (p<0.01) by respiratory gas exchange measurements and 9% (p<0.01) by cardiovascular Fick calculations. The O-2 extraction ratio decreased about 8% (0.001). Conclusions: The addition of dopexamine hydrochloride at a dose of 2 mu g/kg/min resulted in significant increases of DO2 and to a lesser extent V over dot O-2. Much of the global DO2 increase was not utilized, because O-2 extraction ratio decreased. Direct calorigenic effects of dopexamine and an increase in myocardial V over dot O-2 likely account for a large portion of the increase in global V over dot O-2. Whether any of the V over dot O-2 increase reflects improvement in regions of jeopardized tissue oxygenation remains to be clarified before the definite value of this lug in septic shock can be established.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.109.3.756" target="_blank" rel="noreferrer noopener">10.1378/chest.109.3.756</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bredle D L
Chest
consumption
dobutamine
dopexamine hydrochloride
endotoxic dogs
General & Internal Medicine
Hannemann L
Heart failure
infusion
inotropic support
Journal Article or Conference Abstract Publication
lactate
Meierhellmann A
Muscle
O-2 transport
O-2 uptake
optimal values
oxygen delivery
Reinhart K
Respiratory System
respiratory-distress syndrome
sepsis
Septic shock
tissue oxygenation
volume support
Wallenfang G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.105.5.1504" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.105.5.1504</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1504-1510
Issue
5
Volume
105
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prostacyclin In Septic Shock
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-05
Subject
The topic of the resource
critically; delivery; failure; General & Internal Medicine; ill patients; increases oxygen-consumption; infusion; lactate; norepinephrine therapy; Respiratory System; respiratory-distress syndrome; sepsis; tissue oxygenation
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Meierhellmann A; Bredle D L
Description
An account of the resource
Objective: Investigation of the hypothesis that the infusion of 10 ng/kg/min prostacyclin (epoprostenol) (PGI(2)) improves O-2 uptake in patients with hyperdynamic septic shock. Design: Prospective, single cohort design. Setting: ICU, university hospital. Patients: Fifteen postoperative patients with septic shock. Interventions: Infusion of 10 ng/kg/min of PGI(2) for 60 min. Measurements: Complete hemodynamic profile with O-2 transport-related variables (simultaneous measurements of Vo(2) from the respiratory gases and by cardiovascular Fick) and blood lactate levels before start of the PGI(2)-infusion and 60 min thereafter. Main results: Oxygen delivery increased significantly (14 percent) from its already high value, 750+/-238 to 852+/-214 ml/min/m(2). The O-2 extraction ratio remained unchanged. When Vo(2) was measured from the respiratory gases, it was unchanged. When Vo(2) was measured by cardiovascular Fick, it increased slightly (p<0.05). Conclusions: We conclude that in this O-2 challenge test with PGI(2) in patients with septic shock, an increase in O-2 delivery was not matched by an increase in Vo(2). We believe that the adequate conventional support of these patients may have prevented the PGI(2) from revealing a ''covert'' O-2 debt. The PGI(2) test did not predict mortality by O-2 supply dependency. The small increase in Vo(2) as calculated indirectly suggests a degree of mathematical coupling of O-2 delivery and uptake.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.105.5.1504" target="_blank" rel="noreferrer noopener">10.1378/chest.105.5.1504</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
Bredle D L
Chest
critically
Delivery
failure
General & Internal Medicine
Hannemann L
ill patients
increases oxygen-consumption
infusion
Journal Article or Conference Abstract Publication
lactate
Meierhellmann A
norepinephrine therapy
Reinhart K
Respiratory System
respiratory-distress syndrome
sepsis
tissue oxygenation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00024382-199602000-00008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00024382-199602000-00008</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
130-134
Issue
2
Volume
5
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hypertonic Saline In Stabilized Hyperdynamic Sepsis
Publisher
An entity responsible for making the resource available
Shock
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
& Cardiology; cardiac-output; Cardiovascular System; delivery; dogs; fluid resuscitation; General & Internal Medicine; Hematology; hyperosmotic nacl; osmolality; oxygen consumption; respiratory-distress syndrome; septic shock; severe hemorrhagic-shock; Surgery
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Korell R; Spies C; Bredle D L
Description
An account of the resource
Hypertonic saline with or without colloidal solution has been successfully used for treating hemorrhagic shock in animal experiments and clinical studies. Due to its various effects at systemic, organ, and microcirculatory levels, the substance appears to be a promising candidate for improving tissue oxygenation in sepsis. We therefore investigated the hypothesis that infusion of hypertonic saline would further improve O-2 delivery, O-2 extraction, and O-2 uptake in hyperdynamic septic shock patients already stabilized by adequate volume and catecholamine infusion. Twenty-one patients received 2-4 mL/kg body weight of hypertonic saline in hydroxyethyl starch within 15 min. This hypertonic saline infusion caused a rapid significant increase in O-2 delivery by 14% but only a marginal increase in O-2 consumption (7% by cardiovascular Fick [p < .05], 4% by respiratory gases [n.s.]). Hypertonic saline increased the already elevated cardiac output by 24%. The pulmonary capillary wedge pressure increased from 14 +/- 3 to 23 +/- 3 mmHg and pulmonary shunt fraction increased 15%, but arterial PO2 did not fall. Except for the increase in pulmonary capillary wedge pressure, none of the cardiovascular changes lasted longer than 60 min. Plasma sodium levels increased from 138 +/- 25 to 163 +/- 38 mmol/L and normalized within 24 h. In these hyperdynamic septic patients, hypertonic saline infusion produced a transient increase in circulation, but no evidence of a substantial increase in O-2 consumption. Either there was no significant O-2 debt due to the already elevated O-2 delivery levels at baseline (700 mL/min/m(2)) or the global O-2 measurements we used were not able to detect discrete regional hypoxia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00024382-199602000-00008" target="_blank" rel="noreferrer noopener">10.1097/00024382-199602000-00008</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
& Cardiology
1996
Bredle D L
cardiac-output
Cardiovascular System
Delivery
Dogs
fluid resuscitation
General & Internal Medicine
Hannemann L
Hematology
hyperosmotic nacl
Journal Article or Conference Abstract Publication
Korell R
osmolality
Oxygen Consumption
Reinhart K
respiratory-distress syndrome
Septic shock
severe hemorrhagic-shock
Shock
Spies C
Surgery
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00003246-199512000-00004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003246-199512000-00004</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1962-1970
Issue
12
Volume
23
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison Of Dopamine To Dobutamine And Norepinephrine For Oxygen Delivery And Uptake In Septic Shock
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
agents; cardiac-output; catecholamines; consumption; dobutamine; dopamine; General & Internal Medicine; hemodynamics; infusion; inotropic; intra-pulmonary shunt; lactic-acidosis; norepinephrine; oxygen consumption; septic shock; severe sepsis; skeletal-muscle; therapy; transport
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Grenzer O; Meierhellmann A; Bredle D L
Description
An account of the resource
Objectives: To test whether dopamine infusion improves oxygen delivery (D over dot O-2) and oxygen uptake (V over dot O-2) in hyperdynamic septic shock patients stabilized by adequate volume and dobutamine alone, or by the combination of dobutamine and norepinephrine. Design: Prospective clinical trial of two patient groups. Group 1 (n = 15) was stabilized with dobutamine, and group 2 (n = 10) was stabilized with dobutamine and norepinephrine. Setting: Intensive care unit in a university hospital. Patients: Twenty-five postoperative, hyperdynamic septic shock patients. Interventions: The stabilizing catecholamine infusion was replaced in a stepwise manner by dopamine to achieve a similar mean arterial pressure (dopamine doses: group 1, mean 22 +/- 15 mu g/kg/min [range 6 to 52]; and group 2, mean 57 +/- 41 mu g/kg/min [range 15 to 130]). Measurements and Main Results: A complete hemodynamic profile was performed with oxygen transport-related variables at baseline, after replacement by dopamine and after resetting to the original catecholamine infusion. The change to dopamine resulted in increases in cardiac index (group 1: 20% [p < .01]; group 2: 33% [p < .01]), and D over dot O-2 (group 1: 19% [p < .01]; group 2: 27% [p < .01]). However, V over dot O-2, whether directly measured from the respiratory gases or calculated by the cardiovascular Fick principle, did not change in both groups with dopamine, while the oxygen extraction ratio decreased significantly in both groups with dopamine. Heart rate, pulmonary artery occlusion pressure, and pulmonary shunt fraction all increased with dopamine, Pao(2) decreased, but oxygen saturation remained stable in both groups with dopamine. Conclusions: Short-term dopamine infusion in hyperdynamic septic shock patients, de. spite producing higher global D over dot O-2, was not superior to dobutamine or the combination of dobutamine and norepinephrine infusion.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003246-199512000-00004" target="_blank" rel="noreferrer noopener">10.1097/00003246-199512000-00004</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
agents
Bredle D L
cardiac-output
catecholamines
consumption
Critical care medicine
dobutamine
Dopamine
General & Internal Medicine
Grenzer O
Hannemann L
Hemodynamics
infusion
inotropic
intra-pulmonary shunt
Journal Article or Conference Abstract Publication
lactic-acidosis
Meierhellmann A
Norepinephrine
Oxygen Consumption
Reinhart K
Septic shock
severe sepsis
skeletal-muscle
therapy
transport
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.105.4.1217" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.105.4.1217</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1217-1220
Issue
4
Volume
105
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Name That Tone - The Proliferation Of Alarms In The Intensive-care Unit
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-04
Subject
The topic of the resource
General & Internal Medicine; Respiratory System
Creator
An entity primarily responsible for making the resource
Cropp A J; Woods L A; Raney D; Bredle D L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.105.4.1217" target="_blank" rel="noreferrer noopener">10.1378/chest.105.4.1217</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
Bredle D L
Chest
Cropp A J
Department of Internal Medicine
General & Internal Medicine
NEOMED College of Medicine
Raney D
Respiratory System
Woods L A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s001340050264" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s001340050264</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1354-1359
Issue
12
Volume
22
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Splanchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis
Publisher
An entity responsible for making the resource available
Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
sepsis; hypoxia; transport; General & Internal Medicine; metabolism; dopamine; septic shock; norepinephrine; failure; gut; oxygen consumption; endotoxemia; splanchnic oxygen delivery; splanchnic oxygen consumption; critically ill; extraction; splanchnic blood flow
Creator
An entity primarily responsible for making the resource
MeierHellmann A; Specht M; Hannemann L; Hassel H; Bredle D L; Reinhart K
Description
An account of the resource
Objective: To assess global and splanchnic blood flow and oxygen transport in patients with sepsis with and without norepinephrine treatment. Design: Prospective, clinical study. Setting: University hospital intensive care unit. Patients: A convenience sample of 15 septic shock patients treated with norepinephrine and 13 patients with severe sepsis who did not receive norepinephrine. Measurements and main results: There were no differences between the two groups in global haemodynamics and oxygen transport. Splanchnic blood flow and oxygen delivery (splanchnic DO2 303 +/- 43 ml/min per m(2)) and consumption (splanchnic VO2 100 +/- 13 ml/min per m(2)) were much higher in the septic shock group compared with the severe sepsis group (splanchnic DO2 175 +/- 19 ml/min per m(2), splanchnic VO2 61 +/- 6 ml/min per m(2)). Gastric mucosal pH was subnormal in both groups (septic shock 7.29 +/- 0.02, severe sepsis 7.25 +/- 0.02) with no significant difference. No significant differences between groups were detected in lactate values. Conclusion: These data confirm a redistribution of blood flow to the splanchnic region in sepsis that is even more pronounced in patients with septic shock requiring norepinephrine. However, subnormal gastric mucosal pH suggested inadequate oxygenation in parts of the splanchnic region due to factors other than splanchnic hypoperfusion. Progress in this area will depend on techniques that address not only total splanchnic blood flow, but also inter-organ flow distribution, intra-organ distribution, and other microcirculatory or metabolic malfunctions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s001340050264" target="_blank" rel="noreferrer noopener">10.1007/s001340050264</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bredle D L
critically ill
Dopamine
endotoxemia
extraction
failure
General & Internal Medicine
Gut
Hannemann L
Hassel H
hypoxia
Intensive Care Medicine
Journal Article or Conference Abstract Publication
Meierhellmann A
Metabolism
Norepinephrine
Oxygen Consumption
Reinhart K
sepsis
Septic shock
Specht M
splanchnic blood flow
splanchnic oxygen consumption
splanchnic oxygen delivery
transport
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00003246-199703000-00005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003246-199703000-00005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
399-404
Issue
3
Volume
25
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Epinephrine impairs splanchnic perfusion in septic shock
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-03
Subject
The topic of the resource
sepsis; oxygen consumption; General & Internal Medicine; epinephrine; agents; septic shock; norepinephrine; oxygen delivery; critically ill patients; intramural ph; tissue oxygenation; blood flow; oxygen consumption; gastric-mucosal ph; indocyanine green; splanchnic; splanchnic oxygen delivery; dobutamine; hepatic blood-flow; splanchnic oxygen consumption; vasoactive
Creator
An entity primarily responsible for making the resource
MeierHellmann A; Reinhart K; Bredle D L; Specht M; Spies C D; Hannemann L
Description
An account of the resource
Objective: To assess the effects of epinephrine on splanchnic perfusion and splanchnic oxygen uptake in patients with septic shock. Design: Prospective, controlled trial. Setting: University hospital intensive care unit (ICU). Patients: Eight patients with septic shock, according to the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference, requiring treatment with vasopressors. Interventions: We compared in crossover design a 2-hr infusion of epinephrine with dobutamine plus norepinephrine in eight ICU patients with septic shock, Systemic and splanchnic hemodynamics and oxygen transport were measured before and during treatment with epinephrine. Measurements and Main Results: There was essentially no effect of epinephrine on the global parameters, except for increased lactate concentrations, There were marked effects on the regional variables; epinephrine caused lower splanchnic flow and oxygen uptake, lower mucosal pH, and higher hepatic vein lactate. Conclusion: We conclude that undesirable splanchnic effects on patients in whom that region is particularly fragile should be considered when using epinephrine for septic shock treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003246-199703000-00005" target="_blank" rel="noreferrer noopener">10.1097/00003246-199703000-00005</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
agents
blood flow
Bredle D L
Critical care medicine
Critically Ill Patients
dobutamine
Epinephrine
gastric-mucosal ph
General & Internal Medicine
Hannemann L
hepatic blood-flow
Indocyanine Green
intramural ph
Journal Article or Conference Abstract Publication
Meierhellmann A
Norepinephrine
Oxygen Consumption
oxygen delivery
Reinhart K
sepsis
Septic shock
Specht M
Spies C D
splanchnic
splanchnic oxygen consumption
splanchnic oxygen delivery
tissue oxygenation
vasoactive
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s001340050287" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s001340050287</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
31-37
Issue
1
Volume
23
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of low dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock
Publisher
An entity responsible for making the resource available
Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-01
Subject
The topic of the resource
sepsis; injury; oxygen consumption; General & Internal Medicine; epinephrine; dopamine; index; septic shock; oxygen delivery; critically ill patients; consumption; blood flow; endotoxemia; gastric-mucosal ph; indocyanine green; splanchnic; splanchnic oxygen; splanchnic oxygen delivery
Creator
An entity primarily responsible for making the resource
MeierHellmann A; Bredle D L; Specht M; Spies C; Hannemann L; Reinhart K
Description
An account of the resource
Objective. To assess the effects of low-dose dopamine on splanchnic blood flow and splanchnic oxygen uptake in patients with septic shock. Design. Prospective, controlled trial. Setting. University hospital intensive care unit. Patients. 11 patients with septic shock, diagnosed according the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine consensus conference, who required treatment with norepinephrine. Measurements and main results: Systemic and splanchnic hemodynamics and oxygen transport were measured before and during addition of low-dose dopamine (3 mu g/kg per min). Low-dose dopamine had a marked effect on total body hemodynamics and oxygen transport. The fractional splanchnic flow at baseline ranged from 0.15 to 0.57. In 7 patients with a fractional splanchnic flow less than 0.30, low-dose dopamine increased splanchnic flow and splanchnic oxygen delivery and oxygen consumption. In 4 patients with a fractional splanchnic flow above 0.30, low-dose dopamine did not appear to change splanchnic blood flow. Conclusion: Low-dose dopamine has a potential beneficial effect on splanchnic blood flow and oxygen consumption in patients with septic shock, provided the fractional splanchnic flow is not already high before treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s001340050287" target="_blank" rel="noreferrer noopener">10.1007/s001340050287</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
blood flow
Bredle D L
consumption
Critically Ill Patients
Dopamine
endotoxemia
Epinephrine
gastric-mucosal ph
General & Internal Medicine
Hannemann L
index
Indocyanine Green
Injury
Intensive Care Medicine
Journal Article or Conference Abstract Publication
Meierhellmann A
Oxygen Consumption
oxygen delivery
Reinhart K
sepsis
Septic shock
Specht M
Spies C
splanchnic
splanchnic oxygen
splanchnic oxygen delivery
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1001/jama.271.15.1158" target="_blank" rel="noreferrer noopener">http://doi.org/10.1001/jama.271.15.1158</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1158-1158
Issue
15
Volume
271
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CRITICAL OXYGEN DELIVERY IN PATIENTS WITH SEPSIS
Publisher
An entity responsible for making the resource available
Jama-Journal of the American Medical Association
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-04
Subject
The topic of the resource
General & Internal Medicine
Creator
An entity primarily responsible for making the resource
Bredle D L; Reinhart K
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/jama.271.15.1158" target="_blank" rel="noreferrer noopener">10.1001/jama.271.15.1158</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
Bredle D L
General & Internal Medicine
Jama-Journal of the American Medical Association
Journal Article or Conference Abstract Publication
Reinhart K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.103.4.1311c" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.103.4.1311c</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1311-1311
Issue
4
Volume
103
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
ELEVATION OF CARDIAC-OUTPUT AND OXYGEN DELIVERY IMPROVES OUTCOME IN SEPTIC SHOCK
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-04
Subject
The topic of the resource
Respiratory System; General & Internal Medicine
Creator
An entity primarily responsible for making the resource
Bredle D L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.103.4.1311c" target="_blank" rel="noreferrer noopener">10.1378/chest.103.4.1311c</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
Bredle D L
Chest
General & Internal Medicine
Journal Article or Conference Abstract Publication
Respiratory System
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s1081-1206(10)60976-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s1081-1206(10)60976-3</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
817-818
Issue
6
Volume
97
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Title
A name given to the resource
Contact dermatitis to levobunolol eyedrops superimposed on IgE-mediated rhinoconjunctivitis
Publisher
An entity responsible for making the resource available
Annals of Allergy Asthma & Immunology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-12
Subject
The topic of the resource
Immunology; Allergy
Creator
An entity primarily responsible for making the resource
Blumetti B; Brodell R T; Helms S E; Brodell L P; Bredle D L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s1081-1206(10)60976-3" target="_blank" rel="noreferrer noopener">10.1016/s1081-1206(10)60976-3</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2006
allergy
Annals of Allergy Asthma & Immunology
Blumetti B
Bredle D L
Brodell L P
Brodell R T
Helms S E
Immunology
Journal Article or Conference Abstract Publication
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1738-1746
Issue
11
Volume
22
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Dublin Core
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Title
A name given to the resource
INFLUENCE OF N-ACETYLCYSTEINE ON INDIRECT INDICATORS OF TISSUE OXYGENATION IN SEPTIC SHOCK PATIENTS - RESULTS FROM A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND-STUDY
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-11
Subject
The topic of the resource
blood gas analysis; critical illness; critically-ill patients; endotoxin; gastric mucosa; General & Internal Medicine; glutathione; intramural ph; l-arginine; multiple organ failure; n-acetylcysteine; nitric-oxide synthesis; organ failure; oxygen consumption; ph; relaxing factor; sepsis; septic; shock; skeletal-muscle; tissue oxygenation
Creator
An entity primarily responsible for making the resource
Spies C D; Reinhart K; Witt I; Meierhellmann A; Hannemann L; Bredle D L; Schaffartzik W
Description
An account of the resource
Objectives: Deactivation of endothelium-derived relaxing factor due to an increased oxygen radical load during sepsis may contribute to an impairment in microcirculatory blood flow. We investigated whether treatment with the sulfhydryl donor and oxygen radical scavenger, N-acetylcysteine, would improve whole-body oxygen consumption (Vo(2)), gastric intramucosal pH, and veno-arterial CO2 gradient (veno-arterial PCO2) during septic shock. Design: Prospective, randomized, double-blind study conducted over 2 yrs. Setting: Septic shock patients admitted to the intensive care unit. Patients: Fifty-eight patients requiring hemodynamic monitoring (radial and pulmonary artery catheters) due to septic shock, were included in this study. All patients were examined within 72 hrs after the onset of sepsis. They were optimally resuscitated by conventional means with volume and inotropic agents, and exhibited stable clinical conditions (hemodynamic values, body temperature, hemoglobin, FIO2). Interventions: A gastric tonometer was inserted to measure the gastric intramucosal pH. Subjects randomly received either 150 mg/kg of intravenous N-acetylcysteine or placebo over a 15-min period, then a continuous infusion of 12.5 mg/hr of N-acetylcysteine or placebo over similar to 90 mins. Measurements: Infusion measurements were begun 60 mins after the beginning of infusion and lasted similar to 30 mins. The infusion was then discontinued and 2 hrs later the final measurements were taken. Main Results: Basic patient characteristics (age, sex, Acute Physiology and Chronic Health Evaluation [APACHE] II scores, Multiple Organ Failure scores) did not differ significantly, nor did pre- and 2-hr postinfusion measurements differ between any of the groups. Thirteen (45%) patients responded (i.e., showed an increase in Vo(2) >10%, reaching a mean of 19%) to the N-acetylcysteine infusion. The N-acetylcysteine responders also showed an increase in gastric intramucosal pH, a decrease in veno-arterial PCO2, an increase in oxygen delivery, cardiac index, stroke index, and left ventricular stroke work index, as well as a significant decrease in systemic vascular resistance in comparison to baseline. The N-acetylcysteine nonresponders, as well as the patients in the placebo group, did not show any significant changes in any of these variables. The N-acetylcysteine responders had a higher survival rate (69%) than the nonresponders (19%) and were studied earlier after onset of sepsis (37 hrs) than the nonresponders (61 hrs). The only significant difference between the entire N-acetylcysteine group (which included responders plus nonresponders) and the placebo group was an increased 30, in the entire N-acetylcysteine group during infusion measurements. Conclusions: N-acetylcysteine provided a transient improvement in tissue oxygenation in about half of the septic shock patients, as indicated by an increase in Vo(2) and gastric intramucosal pH and a decrease in veno-arterial PCO2. The higher survival rate in the N-acetylcysteine responders and the fact that half of the patients receiving N-acetylcysteine did not respond, suggests that, in some patients, sepsis irreversibly damages the microvasculature to the extent that N-acetylcysteine has no effect. If analyzed by intention to treat, the N-acetylcysteine did not produce effects that were significantly different from the placebo. Whether the N-acetylcysteine challenge was merely diagnostic or whether N-acetylcysteine can be effective in the treatment of sepsis deserves further investigation.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1994
Blood Gas Analysis
Bredle D L
Critical care medicine
Critical Illness
critically-ill patients
endotoxin
gastric mucosa
General & Internal Medicine
Glutathione
Hannemann L
intramural ph
Journal Article
l-arginine
Meierhellmann A
multiple organ failure
n-acetylcysteine
nitric-oxide synthesis
organ failure
Oxygen Consumption
ph
Reinhart K
relaxing factor
Schaffartzik W
sepsis
septic
Shock
skeletal-muscle
Spies C D
tissue oxygenation
Witt I
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
773-779
Issue
3
Volume
151
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Dublin Core
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Title
A name given to the resource
N-ACETYLCYSTEINE PRESERVES OXYGEN-CONSUMPTION AND GASTRIC-MUCOSAL PH DURING HYPEROXIC VENTILATION
Publisher
An entity responsible for making the resource available
American Journal of Respiratory and Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-03
Subject
The topic of the resource
cardiac-output; critically-ill patients; endotoxin; gas-exchange; General & Internal Medicine; l-arginine; nitric-oxide synthesis; relaxing factor; Respiratory System; septic patients; skeletal-muscle; superoxide
Creator
An entity primarily responsible for making the resource
Reinhart K; Spies C D; Meierhellmann A; Bredle D L; Hannemann L; Specht M; Schaffartzik W
Description
An account of the resource
Hyperoxic ventilation, used to prevent hypoxemia during potential periods of hypoventilation, has been reported to paradoxically decrease whole body oxygen consumption (Vo(2)). Reduction in nutritive blood flow due to oxygen radical production is one possible mechanism. We investigated whether pretreatment with the sulfhydryl group donor and O-2 radical scavenger N-acetylcysteine (NAG) would preserve whole body Vo(2) and prevent deterioration of oxygenation in gastric mucosal tissue during hyperoxia. Thirty-eight patients, requiring hemodynamic monitoring (radial and pulmonary artery catheters) due to sepsis syndrome, were included in this randomized experiment. All patients exhibited stable clinical conditions (hemodynamics, body temperature, hemoglobin, Flo(2) < 0.5). A gastric tonometer was placed to measure the gastric intramucosal pH (pH(i)), which indirectly assesses nutritive blood flow to the mucosa. Cardiac output was determined by thermodilution and Vo(2) by cardiovascular Fick. After baseline measurements, patients randomly received either 150 mg . kg(-1) NAC (n = 19) or placebo (n = 19) in 250 ml 5% dextrose intravenously over a period of 15 min. Measurements were repeated 30 min after starting NAC or placebo infusion, 30 min after starting hyperoxia (Flo(2) = 1.0), and 60 min after resetting the original Flo(2). There were no significant differences between groups in any of the measurements before treatment and after the return to baseline Flo(2) at the end of the study. NAG, but not placebo infusion, caused a slight but significant increase in cardiac output and decrease in systemic vascular resistance. Significant differences between groups during hyperoxia were: Vo(2) (NAG: 114 +/- 9 mi min(-1) m(-2) versus placebo: 81 +/- 31 ml . min(-1) m(-2); p = 0.008) and oxygen extraction ratio (NAG: 21 +/- 6% versus placebo: 14 +/- 5%; p = 0.003). The mean decrease of Vo(2) was 11% in the NAC group versus 34% in the placebo group. The mean decrease of the oxygen extraction ratio was 12% in the NAC group versus 34% in the placebo group. NAC prevented a decrease in pH(i) in hyperoxia (NAG: 7.28 +/- 0.10 versus placebo: 7.14 +/- 0.18; p = 0.012). NAC helped preserve whole body oxygen uptake, oxygen extraction ratio, and pH(i) during brief hyperoxia in these septic patients. This suggests that pretreatment with NAC can attenuate impaired tissue oxygenation during hyperoxia.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1995
American journal of respiratory and critical care medicine
Bredle D L
cardiac-output
critically-ill patients
endotoxin
gas-exchange
General & Internal Medicine
Hannemann L
Journal Article
l-arginine
Meierhellmann A
nitric-oxide synthesis
Reinhart K
relaxing factor
Respiratory System
Schaffartzik W
septic patients
skeletal-muscle
Specht M
Spies C D
superoxide
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s001340050403" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s001340050403</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
743-748
Issue
7
Volume
23
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Title
A name given to the resource
A controlled study of leukocyte activation in septic patients
Publisher
An entity responsible for making the resource available
Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-07
Subject
The topic of the resource
alpha; burst; chemi-luminescence; chemi-luminescence; formyl-methionyl-leucyl-phenyl alanine; General & Internal Medicine; leukocytes; luminol; neutrophils; opsonized zymosan; oxidative burst; phagocytes; phorbol myristate acetate; polymorphonuclear; respiratory burst; sepsis; septic shock; shock; tumor-necrosis-factor
Creator
An entity primarily responsible for making the resource
Pascual C; Karzai W; Meierhellmann A; Bredle D L; Reinhart K
Description
An account of the resource
Objective: Qualitative and quantitative evaluation of leukocyte activation in septic patients in comparison to two control groups. Design: A prospective clinical study in which the leukocyte oxidative output of whole blood was measured in three groups of patients. Two chemiluminescence markers (luminol or lucigenin), indicative of either total oxidant output or superoxide production, and three stimuli (opsonized zymosan, formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate) (PMA), representing different pathways of leukocyte activation, were used. Tumor necrosis factor, interleukin-6 and C-reactive protein (TNF, IL-6, and CRP) were determined to evaluate the severity of the inflammatory process. Setting: Intensive care and surgical units of a university hospital. Patients: Seventy-four healthy patients, ten ICU patients without signs of sepsis or systemic inflammatory response syndrome and 19 septic patients were studied. Measurement and main results: With all three stimuli, whole blood total oxidative output and superoxide production were generally increased in septic patients. This was most likely due to the increased leukocyte numbers in these patients. When the chemiluminescence values were normalized per phagocyte (granulocytes and monocytes), the total oxidative output of septic phagocytes decreased with opsonin and fMLP but increased with PMA, while superoxide output decreased regardless of the stimuli used. TNF, IL-6 and CRP, although increased in septic patients as compared to ICU controls, correlated weakly with oxidant output. Conclusions: The oxidative output of whole blood was increased in septic patients compared to controls because of elevated leukocyte numbers. However, oxidant output normalized for phagocyte numbers generally decreases during sepsis for most stimuli. Cytokines and CRP do not appear to be associated with the extent of oxidant output during sepsis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s001340050403" target="_blank" rel="noreferrer noopener">10.1007/s001340050403</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1997
alpha
Bredle D L
burst
chemi-luminescence
formyl-methionyl-leucyl-phenyl alanine
General & Internal Medicine
Intensive Care Medicine
Journal Article
Karzai W
LEUKOCYTES
luminol
Meierhellmann A
Neutrophils
opsonized zymosan
oxidative burst
Pascual C
phagocytes
phorbol myristate acetate
polymorphonuclear
Reinhart K
respiratory burst
sepsis
Septic shock
Shock
tumor-necrosis-factor
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
51–88
Issue
10
Volume
23
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Imaging quiz. 'Flesh-eating bacteria'?
Publisher
An entity responsible for making the resource available
Physician & Sportsmedicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
Male; Education; Middle Age; Continuing (Credit); Arm – Physiopathology; Foreign Bodies – Diagnosis
Creator
An entity primarily responsible for making the resource
Jain R; Bredle D L; Helms S E; Brodell R T
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Arm – Physiopathology
Bredle D L
Brodell R T
Continuing (Credit)
Education
Foreign Bodies – Diagnosis
Helms S E
Jain R
Male
Middle Age
Physician & Sportsmedicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
277–279
Issue
2
Volume
90
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Randomized comparison of gastric pH control with intermittent and continuous intravenous infusion of famotidine in ICU patients.
Publisher
An entity responsible for making the resource available
The American journal of gastroenterology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-02
Subject
The topic of the resource
Female; Humans; Male; Middle Aged; Aged; Treatment Outcome; Prospective Studies; Analysis of Variance; Double-Blind Method; Hydrogen-Ion Concentration; Intensive Care Units; Drug Administration Schedule; Famotidine/administration & dosage/*therapeutic use; Stomach Ulcer/blood/etiology/*prevention & control; Stomach/*drug effects/physiopathology; Infusions; Intravenous
Creator
An entity primarily responsible for making the resource
Heiselman D E; Hulisz D T; Fricker R; Bredle D L; Black L D
Description
An account of the resource
OBJECTIVE: To compare gastric pH control using intravenous famotidine as a primed, continuous infusion versus intermittent infusion. METHODS: In a prospective, double-blind study, 40 ICU patients at risk for stress ulceration were randomly assigned to receive either famotidine 20 mg intravenous bolus followed by 1.67 mg/h infusion or famotidine 20 mg intravenously every 12 h. Intraluminal gastric pH was recorded at baseline and every 4 h using a glass electrode. Clinical outcome indicators were also monitored. Subjects were studied for a minimum of 24 h and a maximum of 6 days. Continuous variables were analyzed by ANOVA and nominal variables by Fisher's exact test (alpha = 0.05). RESULTS: Nineteen patients were randomized to the continuous infusion group, and 21 were randomized to the intermittent group. Using gastric pH greater than 4.0 as an endpoint, the continuous group exhibited better pH control, both in terms of percentage of total measurements (83% versus 63%, p \textless 0.001) and time spent above pH 4.0 (91% versus 76%, p \textless 0.01). Similar results were found at pH greater than 5.0 (78% versus 56% for all measurements for the continuous and bolus groups, respectively (p \textless 0.001), and 88% versus 72% for the time spent above pH 5.0 (p \textless 0.01). Clinical outcomes, including evidence for gastrointestinal bleeding and hospital mortality, did not differ significantly between groups. CONCLUSION: Famotidine infusion at 1.67 mg/h, when preceded by a bolus dose of 20 mg, provides a greater and more sustained increase in gastric pH than intermittent administration of famotidine 20 mg every 12 h.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Aged
Analysis of Variance
Black L D
Bredle D L
Department of Internal Medicine
Double-Blind Method
Drug Administration Schedule
Famotidine/administration & dosage/*therapeutic use
Female
Fricker R
Heiselman D E
Hulisz D T
Humans
Hydrogen-Ion Concentration
Infusions
Intensive Care Units
Intravenous
Male
Middle Aged
NEOMED College of Medicine
Prospective Studies
Stomach Ulcer/blood/etiology/*prevention & control
Stomach/*drug effects/physiopathology
The American journal of gastroenterology
Treatment Outcome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3810/pgm.1999.04.714" target="_blank" rel="noreferrer noopener">http://doi.org/10.3810/pgm.1999.04.714</a>
Pages
220, 223–224
Issue
4
Volume
105
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Persistent contact dermatitis. When a cause can't be found, consider the cure.
Publisher
An entity responsible for making the resource available
Postgraduate medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-04
Subject
The topic of the resource
Humans; Male; Middle Aged; Patch Tests; Adrenal Cortex Hormones/*adverse effects/immunology; Cross Reactions; Dermatologic Agents/*adverse effects/immunology; Excipients/*adverse effects; Shoes/adverse effects; Waxes/*adverse effects; Dermatitis; Contact/drug therapy/*etiology/immunology
Creator
An entity primarily responsible for making the resource
Helms S E; Brodell R T; Bredle D L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3810/pgm.1999.04.714" target="_blank" rel="noreferrer noopener">10.3810/pgm.1999.04.714</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Adrenal Cortex Hormones/*adverse effects/immunology
Bredle D L
Brodell R T
Contact/drug therapy/*etiology/immunology
Cross Reactions
Dermatitis
Dermatologic Agents/*adverse effects/immunology
Excipients/*adverse effects
Helms S E
Humans
Male
Middle Aged
Patch Tests
Postgraduate medicine
Shoes/adverse effects
Waxes/*adverse effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1176/ps.48.10.1323" target="_blank" rel="noreferrer noopener">http://doi.org/10.1176/ps.48.10.1323</a>
Pages
1323–1327
Issue
10
Volume
48
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Relevance of routine admission electrocardiograms for psychiatric patients.
Publisher
An entity responsible for making the resource available
Psychiatric services (Washington, D.C.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-10
Subject
The topic of the resource
Adult; Aged; Arrhythmias; Cardiac/diagnosis/*epidemiology/etiology; Comorbidity; Cost Savings; Diagnosis; Diagnostic Tests; Dual (Psychiatry); Electrocardiography/economics/*statistics & numerical data; Female; Humans; Male; Mental Disorders/diagnosis/*epidemiology/rehabilitation; Middle Aged; Myocardial Ischemia/diagnosis/*epidemiology/etiology; Patient Admission/economics/*statistics & numerical data; Routine/economics/*statistics & numerical data; Sensitivity and Specificity; Treatment Outcome
Creator
An entity primarily responsible for making the resource
Heiselman D E; Bredle D L; Kessler E; Rutecki G W; Hines R M; Whittier F C; Bunn P D; Ognibene A J
Description
An account of the resource
OBJECTIVE: To make clinically relevant recommendations for electrocardiogram (ECG) testing among psychiatric patients, the study examined the practice of ordering ECGs for this population. METHODS: The records of 4,045 patients consecutively admitted for psychiatric care to seven community teaching hospitals over one year were examined. The frequency of ECG orders was documented, and abnormal ECG results were grouped into two categories: relevant to psychiatric treatment (ischemia or conduction defects) and incidental to treatment (minor abnormalities and screening abnormalities). For those with abnormalities, additional cardiac follow-up data were recorded. Associations between ECG results and patients' characteristics were analyzed. RESULTS: ECGs were performed for 2,857 (71 percent) of first admissions, of which 2,225 (78 percent) showed neither relevant nor screening abnormalities. Eighteen percent of those tested had relevant abnormalities, most commonly a first-degree atrioventricular block or some evidence of a myocardial infarction. ECG screening abnormalities were found for another 4 percent, primarily left ventricular hypertrophy (3 percent), but no follow-up occurred for 46 percent of these patients. Among patients under 40 years of age, 8 percent had relevant abnormalities, and 3 percent had screening abnormalities. Among patients without apparent cardiac risk, 10 percent had relevant and 3 percent had screening abnormalities. More than half the patients who had a second or third admission during the year had a repeat ECG, even when previous ECGs were normal. CONCLUSIONS: Routine ECG is not an effective treatment or screening tool in this population, and substantial cost savings could result from more selective testing, particularly among young patients, those at low risk, and those with repeat admissions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1176/ps.48.10.1323" target="_blank" rel="noreferrer noopener">10.1176/ps.48.10.1323</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Adult
Aged
Arrhythmias
Bredle D L
Bunn P D
Cardiac/diagnosis/*epidemiology/etiology
Comorbidity
Cost Savings
Department of Family & Community Medicine
Department of Internal Medicine
Diagnosis
Diagnostic Tests
Dual (Psychiatry)
Electrocardiography/economics/*statistics & numerical data
Female
Heiselman D E
Hines R M
Humans
Kessler E
Male
Mental Disorders/diagnosis/*epidemiology/rehabilitation
Middle Aged
Myocardial Ischemia/diagnosis/*epidemiology/etiology
NEOMED College of Medicine
Ognibene A J
Patient Admission/economics/*statistics & numerical data
Psychiatric services (Washington, D.C.)
Routine/economics/*statistics & numerical data
Rutecki G W
Sensitivity and Specificity
Treatment Outcome
Whittier F C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1524-4725.1995.tb00155.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1524-4725.1995.tb00155.x</a>
Pages
213–218
Issue
3
Volume
21
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The treatment of palmar and plantar warts using natural alpha interferon and a needleless injector.
Publisher
An entity responsible for making the resource available
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-03
Subject
The topic of the resource
Adolescent; Adult; Child; Female; Foot Dermatoses/*therapy; Hand Dermatoses/*therapy; Humans; Injections; Interferon-alpha/*administration & dosage/therapeutic use; Intralesional; Jet; Male; Middle Aged; Warts/*therapy
Creator
An entity primarily responsible for making the resource
Brodell R T; Bredle D L
Description
An account of the resource
BACKGROUND: The treatment of palmar and plantar warts is difficult and often frustrating. The need for multiple destructive treatments and recurrences after apparent cure are common. OBJECTIVE: The purpose of this study was to determine if intralesional natural alpha interferon might offer an effective alternative therapy for common plantar and palmar warts. METHODS: A series of 22 private office patients with palmar and plantar warts were treated with intralesional natural alpha interferon using a needless injector. We treated twice weekly for a minimum of 8 weeks or until clear. RESULTS: Sixteen patients (73%) showed complete clearing of their warts in a mean of 11 weeks of twice weekly treatment. Upon follow-up, which averaged 9.5 months, 17 of 21 patients (81%) remained clear of their warts. CONCLUSION: Natural alpha interferon by needless injector appears to represent an effective alternative treatment for palmar and plantar human papillomavirus lesions. Further study of this modality is indicated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1524-4725.1995.tb00155.x" target="_blank" rel="noreferrer noopener">10.1111/j.1524-4725.1995.tb00155.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Adolescent
Adult
Bredle D L
Brodell R T
Child
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Female
Foot Dermatoses/*therapy
Hand Dermatoses/*therapy
Humans
Injections
Interferon-alpha/*administration & dosage/therapeutic use
Intralesional
Jet
Male
Middle Aged
Warts/*therapy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0190-9622(97)80322-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0190-9622(97)80322-2</a>
Pages
705–710
Issue
5
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Oral contraceptive failure rates and oral antibiotics.
Publisher
An entity responsible for making the resource available
Journal of the American Academy of Dermatology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-05
Subject
The topic of the resource
*Antibiotics; *Case Control Studies; *Contraception Failure; *Contraceptives; *Drug Interactions; *Oral Contraceptives–side effects; *Pregnancy; *Research Report; Administration; Adolescent; Adult; Americas; Anti-Bacterial Agents/*administration & dosage/adverse effects; Combined; Contraception; Contraceptive Methods–side effects; Contraceptive Usage; Dermatology; Developed Countries; Drug Interactions; Drugs; Family Planning; Female; Humans; North America; Northern America; Oral; Research Methodology; Retrospective Studies; Studies; Treatment; United States
Creator
An entity primarily responsible for making the resource
Helms S E; Bredle D L; Zajic J; Jarjoura D; Brodell R T; KrishnaRao I
Description
An account of the resource
BACKGROUND: Despite anecdotal evidence of a possibility of decreased effectiveness of oral contraceptives (OCs) with some antibiotics, it is not known whether antibiotic use in dermatologic practices engenders any increased risk of accidental pregnancy. OBJECTIVE: Our purpose was to examine the effect of commonly prescribed oral antibiotics (tetracyclines, penicillins, cephalosporins) on the failure rate of OCs. METHODS: The records from three dermatology practices were reviewed, and 356 patients with a history of combined oral antibiotic/OC use were surveyed retrospectively. Of these patients, 263 also provided "control" data (during the times they used OCs alone). An additional 162 patients provided control data only. RESULTS: Five pregnancies occurred in 311 woman-years of combined antibiotic/OC exposure (1.6% per year failure rate) compared with 12 pregnancies in 1245 woman-years of exposure (0.96% per year) for the 425 control patients. This difference was not significant (p = 0.4), and the 95% confidence interval on the difference (-0.81, 2.1) ruled out a substantial difference (\textgreater 2.1% per year). There was also no significant difference between OC failure rates for the women who provided data under both conditions, nor between the two control groups. All our data groups had failure rates below the 3% or higher per year, which are typically found in the United States. CONCLUSION: The difference in failure rates of OCs when taken concurrently with antibiotics commonly used in dermatology versus OC use alone suggests that these antibiotics do not increase the risk of pregnancy. Physicians and patients need to recognize that the expected OC failure rate, regardless of antibiotic use, is at least 1% per year and it is not yet possible to predict in whom OCs may fail.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0190-9622(97)80322-2" target="_blank" rel="noreferrer noopener">10.1016/s0190-9622(97)80322-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Antibiotics
*Case Control Studies
*Contraception Failure
*Contraceptives
*Drug Interactions
*Oral Contraceptives–side effects
*Pregnancy
*Research Report
1997
Administration
Adolescent
Adult
Americas
Anti-Bacterial Agents/*administration & dosage/adverse effects
Bredle D L
Brodell R T
Combined
Contraception
Contraceptive Methods–side effects
Contraceptive Usage
Dermatology
Developed Countries
Drug Interactions
Drugs
Family Planning
Female
Helms S E
Humans
Jarjoura D
Journal of the American Academy of Dermatology
KrishnaRao I
North America
Northern America
Oral
Research Methodology
Retrospective Studies
Studies
Treatment
United States
Zajic J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1001/archfami.6.3.296" target="_blank" rel="noreferrer noopener">http://doi.org/10.1001/archfami.6.3.296</a>
Pages
296–298
Issue
3
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prescription errors. Legibility and drug name confusion.
Publisher
An entity responsible for making the resource available
Archives of family medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-06
Subject
The topic of the resource
*Handwriting; *Medication Errors; Humans; Interprofessional Relations
Creator
An entity primarily responsible for making the resource
Brodell R T; Helms S E; KrishnaRao I; Bredle D L
Description
An account of the resource
Inadvertent drug substitution occurred in several instances in our practices due to the combination of the physician's illegible handwriting on prescriptions and the pharmacist's misinterpretation of subtle clues, which might have prevented the errors. The literature on the legibility of physician handwriting is reviewed. Our specific recommendations include using preprinted prescription pads, training staff assistants who write prescriptions, printing complete directions on each prescription, and aggressively educating each patient about the name and purpose of all drugs being prescribed. Patients are encouraged to bring their medications to each office visit to identify potential errors.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/archfami.6.3.296" target="_blank" rel="noreferrer noopener">10.1001/archfami.6.3.296</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Handwriting
*Medication Errors
1997
Archives of family medicine
Bredle D L
Brodell R T
Helms S E
Humans
Interprofessional Relations
KrishnaRao I