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Text
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URL Address
<a href="http://doi.org/10.1152/ajpheart.00099.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00099.2002</a>
Pages
H2062–2073
Issue
5
Volume
283
Dublin Core
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Title
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Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.
Publisher
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American journal of physiology. Heart and circulatory physiology
Date
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2002
2002-11
Subject
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*Sex Characteristics; Animals; Aorta/drug effects/physiology; Bridged Bicyclo Compounds; Cyclooxygenase Inhibitors/pharmacology; Endothelium; Enzyme Inhibitors/pharmacology; Estrogens/*physiology; Fatty Acids; Female; Heterocyclic; Hydrazines/pharmacology; Imidazoles/pharmacology; Indomethacin/pharmacology; Male; Ovariectomy; Phenylephrine/pharmacology; Progesterone/*physiology; Prostaglandins/*metabolism; Rats; Sprague-Dawley; Thromboxanes/metabolism; Unsaturated; Vascular/*metabolism; Vasoconstriction/drug effects/*physiology; Vasoconstrictor Agents/pharmacology; Vasopressins/pharmacology
Creator
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Fulton Clifford T; Stallone John N
Description
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The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile response of control (Cont) aortas to VP was markedly higher in females (3,885 +/- 332 mg/mg ring wt) than in males (810 +/- 148 mg). Indomethacin (Indo; 10 microM) attenuated maximal response to VP in females (3,043 +/- 277 mg) but not in males. SQ-29,548 (SQ; 1 microM) attenuated maximal response to VP in females (3,042 +/- 290 mg) to a similar extent as Indo. Dazoxiben (Daz; 10 microM) alone had no effect, but Daz + SQ attenuated maximal contractile response to VP to a similar extent as SQ alone. Removal of the endothelium in female aortas attenuated contractile responses to VP in Cont aortas. OVX attenuated maximal contractile response to VP in Cont aortas (2,093 +/- 329 mg) and abolished the attenuating effects of Indo. Indo, SQ, and Daz exerted identical effects on contractile responses of male, female, and OVX female aortas to PE. These findings establish the following in the rat aorta: 1) CP, probably thromboxane and/or endoperoxide, is responsible for approximately
Identifier
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<a href="http://doi.org/10.1152/ajpheart.00099.2002" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00099.2002</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2002
American journal of physiology. Heart and circulatory physiology
Animals
Aorta/drug effects/physiology
Bridged Bicyclo Compounds
Cyclooxygenase Inhibitors/pharmacology
Endothelium
Enzyme Inhibitors/pharmacology
Estrogens/*physiology
Fatty Acids
Female
Fulton Clifford T
Heterocyclic
Hydrazines/pharmacology
Imidazoles/pharmacology
Indomethacin/pharmacology
Male
Ovariectomy
Phenylephrine/pharmacology
Progesterone/*physiology
Prostaglandins/*metabolism
Rats
Sprague-Dawley
Stallone John N
Thromboxanes/metabolism
Unsaturated
Vascular/*metabolism
Vasoconstriction/drug effects/*physiology
Vasoconstrictor Agents/pharmacology
Vasopressins/pharmacology