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Text
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URL Address
<a href="http://doi.org/10.3109/1061186X.2011.589435" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/1061186X.2011.589435</a>
Pages
837–845
Issue
9
Volume
19
Dublin Core
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Title
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Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.
Publisher
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Journal of drug targeting
Date
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2011
2011-11
Subject
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Humans; Male; Animals; Mice; *Drug Delivery Systems; Rats; Cell Line; Nanoparticles; Permeability; Particle Size; Delayed-Action Preparations; Blood-Brain Barrier/metabolism; Adenosine Triphosphatases/metabolism; Brain Neoplasms/drug therapy; Cell Death/drug effects; Coumarins/administration & dosage/pharmacokinetics; Glioma/drug therapy/pathology; Glutathione/*chemistry; Microtubules/metabolism; Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology; Thiazoles/administration & dosage/pharmacokinetics; Tubulin/metabolism; Inbred C57BL; Tumor; ATP Binding Cassette Transporter; Antineoplastic Agents; Member 1/metabolism; Subfamily B; Phytogenic/administration & dosage/*pharmacokinetics/pharmacology
Creator
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Geldenhuys Werner; Mbimba Thomas; Bui Thong; Harrison Kimberly; Sutariya Vijaykumar
Description
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Paclitaxel is not effective for treatment of brain cancers because it cannot cross the blood-brain barrier (BBB) due to efflux by P-glycoprotein (P-gp). In this work, glutathione-coated poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) of paclitaxel were developed for brain targeting for treatment of brain cancers. P-gp ATPase assay was used to evaluate the NP as potential substrates. The NP showed a particle size suitable for BBB permeation (particle size around 200 nm) and higher cellular uptake of the NP was demonstrated in RG2 cells. The
Identifier
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<a href="http://doi.org/10.3109/1061186X.2011.589435" target="_blank" rel="noreferrer noopener">10.3109/1061186X.2011.589435</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Drug Delivery Systems
2011
Adenosine Triphosphatases/metabolism
Animals
Antineoplastic Agents
ATP Binding Cassette Transporter
Blood-Brain Barrier/metabolism
Brain Neoplasms/drug therapy
Bui Thong
Cell Death/drug effects
Cell Line
Coumarins/administration & dosage/pharmacokinetics
Delayed-Action Preparations
Geldenhuys Werner
Glioma/drug therapy/pathology
Glutathione/*chemistry
Harrison Kimberly
Humans
Inbred C57BL
Journal of drug targeting
Male
Mbimba Thomas
Member 1/metabolism
Mice
Microtubules/metabolism
Nanoparticles
Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology
Particle Size
Permeability
Phytogenic/administration & dosage/*pharmacokinetics/pharmacology
Rats
Subfamily B
Sutariya Vijaykumar
Thiazoles/administration & dosage/pharmacokinetics
Tubulin/metabolism
Tumor