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Text
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URL Address
<a href="http://doi.org/10.1046/j.1524-475x.2003.11208.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1524-475x.2003.11208.x</a>
Pages
127–131
Issue
2
Volume
11
Dublin Core
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Title
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Effects of vascular endothelial growth factor on wound closure rates in the genetically diabetic mouse model.
Publisher
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Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Date
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2003
2003-04
Subject
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Administration; Angiogenesis Inducing Agents/*administration & dosage; Animal; Animals; Diabetes Mellitus/*physiopathology; Endothelial Growth Factors/*administration & dosage; Intercellular Signaling Peptides and Proteins/*administration & dosage; Lymphokines/*administration & dosage; Mice; Models; Topical; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing/*drug effects
Creator
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Kirchner Loren M; Meerbaum Sharon O; Gruber Brian S; Knoll Andrew K; Bulgrin Jeffery; Taylor R A J; Schmidt Steven P
Description
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Impaired wound healing is characteristic of diabetic patients. Potential reasons include poor inflammatory response, granulation tissue formation, and abnormal patterns of cytokine release and response. Vascular endothelial growth factor, abnormally regulated during healing in diabetics, is the major factor stimulating angiogenesis during normal wound healing. We tested our hypothesis that topically applied vascular endothelial growth factor would improve wound closure rates in diabetic animals in a full-thickness wound model in genetically diabetic mice (C57 BL/KsJ db/db). Animals received either 1.0 micro g of vascular endothelial growth factor165 or polyethylene glycol alone topically to wounds daily between days 0 and 4 post-wounding. Wound area was measured at days 0, 5, 10, 15, and 21. Data were analyzed using probit analysis and expressed as length-of-time (LT) to 50, 90, and 95% wound closure. Among untreated animals, nondiabetics had an LT50 of 8.5 days (fiducial limits 8.3-8.7), while diabetics had an LT50 of 15.8 days (15.6-16.1). Vascular endothelial growth factor-treated animals had LT50 values of 7.8 (7.6-8.1) and 11.8 days (11.6-12.0) for nondiabetics and diabetics, respectively, representing a 25% improvement in time to 50% closure in treated diabetics. We conclude that topically applied vascular endothelial growth factor improves time to wound closure in the genetically diabetic mouse model.
Identifier
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<a href="http://doi.org/10.1046/j.1524-475x.2003.11208.x" target="_blank" rel="noreferrer noopener">10.1046/j.1524-475x.2003.11208.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Administration
Angiogenesis Inducing Agents/*administration & dosage
Animal
Animals
Bulgrin Jeffery
College of Graduate Studies
Department of Pharmaceutical Sciences
Diabetes Mellitus/*physiopathology
Endothelial Growth Factors/*administration & dosage
Gruber Brian S
Intercellular Signaling Peptides and Proteins/*administration & dosage
Kirchner Loren M
Knoll Andrew K
Lymphokines/*administration & dosage
Meerbaum Sharon O
Mice
Models
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Schmidt Steven P
Taylor R A J
Topical
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Wound Healing/*drug effects
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society