1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41581-020-0267-8</a>
ISSN
1759-507X 1759-5061
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1038/s41581-020-0267-8</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.
Publisher
An entity responsible for making the resource available
Nature reviews. Nephrology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04-08
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Bedoyan Jirair K; Lichter-Konecki Uta; Jouvet Philippe; Picca Stefano; Mew Nicholas Ah; Machado Marcel C; Chakraborty Ronith; Vemuganti Meghana; Grewal Manpreet K; Bunchman Timothy; Sethi Sidharth Kumar; Krishnappa Vinod; McCulloch Mignon; Alhasan Khalid; Bagga Arvind; Basu Rajit K; Schaefer Franz; Filler Guido; Warady Bradley A
Description
An account of the resource
Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial. This expert Consensus Statement presents recommendations for the management of hyperammonaemia requiring KRT in paediatric populations. Additional studies are required to strengthen these recommendations.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">10.1038/s41581-020-0267-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Alhasan Khalid
Bagga Arvind
Basu Rajit K
Bedoyan Jirair K
Bunchman Timothy
Chakraborty Ronith
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Filler Guido
Grewal Manpreet K
journalArticle
Jouvet Philippe
June 2020 Update II
Krishnappa Vinod
Lichter-Konecki Uta
Machado Marcel C
McCulloch Mignon
Mew Nicholas Ah
Nature reviews. Nephrology
NEOMED College of Medicine
Picca Stefano
Raina Rupesh
Schaefer Franz
Sethi Sidharth Kumar
Vemuganti Meghana
Warady Bradley A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fped.2019.00454</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
454
Volume
7
ISSN
2296-2360
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fped.2019.00454</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
January 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Affiliated Hospital
Cleveland Clinic Akron General
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dextran-Sulfate Plasma Adsorption Lipoprotein Apheresis in Drug Resistant Primary Focal Segmental Glomerulosclerosis Patients: Results From a Prospective, Multicenter, Single-Arm Intervention Study
Publisher
An entity responsible for making the resource available
Frontiers in Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
1905-07
Subject
The topic of the resource
focal segmental glomerulosclerosis; lipoprotein apheresis; liposorber; nephrotic syndrome; proteinuria
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Krishnappa Vinod; Sanchez-Kazi Cheryl; Quiroga Alejandro; Twombley Katherine E; Mathias Robert; Lo Megan; Chakraborty Ronith; Mahesh Shefali; Steinke Julia; Bunchman Timothy; Zaritsky Joshua
Description
An account of the resource
Background: Focal segmental glomerulosclerosis (FSGS) causes end stage renal disease (ESRD) in significant proportion of patients worldwide. Primary FSGS carries poor prognosis and management of FSGS patients, refractory to standard treatments or resistant to steroids, remains a major challenge. Lipoprotein apheresis is a therapeutic approach for drug resistant primary FSGS and post-renal transplant primary FSGS recurrence. Objectives: To examine the safety and probable benefit at 1, 3, 6, 12, and 24-months following completion of apheresis treatment using Liposorber® LA-15 system in patients with nephrotic syndrome (NS), due to refractory primary FSGS or primary FSGS associated NS, in post renal transplant children. Material and Methods: Prospective, multicenter, single-arm intervention study using Liposorber® LA-15 system. Patients ≤21 years old with drug resistant or drug intolerant NS secondary to primary FSGS with glomerular filtration rate (GFR) ≥60 ml/min/1.73 m2 or post renal transplant patients ≤21 years old with primary FSGS associated NS were included in the study. Each patient had 12 dextran-sulfate plasma adsorption lipoprotein apheresis sessions over a period of 9 weeks. All patients were followed up at 1, 3, 6, 12, and 24-months following completion of treatment. Results: Of 17 patients enrolled, six were excluded from the outcome analysis (protocol deviations). Of the remaining 11 patients, all but one have completed apheresis treatments. Three patients were lost to follow-up immediately after completion of apheresis and excluded from outcome analysis. At one-month follow-up, 1 of 7 patients (14.3%) attained partial remission of NS while 2 of 4 subjects (50%) and 2 of 3 subjects (66.7%) had partial/complete remission at 3- and 6-months follow-up, respectively. One of two patients followed up for 12 months had complete remission and one patient had partial remission of NS after 24 months. Improved or stable eGFR was noted in all patients over the follow-up period. Conclusion: The results of our multicenter study showed improvement in the response rates to steroid or immunosuppressive therapy and induced complete or partial remission of proteinuria in some of the patients with drug resistant primary FSGS. The main limitation of our study is the small number of subjects and high dropout rate.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">10.3389/fped.2019.00454</a>
PMID: 31850285 PMCID: PMC6902874
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Bunchman Timothy
Chakraborty Ronith
Focal segmental glomerulosclerosis
Frontiers in pediatrics
January 2020 Update
Journal Article
Krishnappa Vinod
Lipoprotein apheresis
liposorber
Lo Megan
Mahesh Shefali
Mathias Robert
NEOMED College of Graduate Studies Student
NEOMED Student Publications
Nephrotic syndrome
Proteinuria
Quiroga Alejandro
Raina Rupesh
Sanchez-Kazi Cheryl
Steinke Julia
Twombley Katherine E
Zaritsky Joshua
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00467-018-4190-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00467-018-4190-1</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
925-941
Issue
5
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup
Publisher
An entity responsible for making the resource available
Pediatric Nephrology (Berlin, Germany)
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-05
Subject
The topic of the resource
Blood pressure monitoring; Blood volume monitoring; Children; Dialysate cooling; Intradialytic hypotension; Mannitol; Midodrine; Sodium profiling
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Lam Stephanie; Raheja Hershita; Krishnappa Vinod; Hothi Daljit; Davenport Andrew; Chand Deepa; Kapur Gaurav; Schaefer Franz; Sethi Sidharth Kumar; McCulloch Mignon; Bagga Arvind; Bunchman Timothy; Warady Bradley A
Description
An account of the resource
Intradialytic hypotension (IDH) is a common adverse event resulting in premature interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH occurs in response to the reduction in blood volume during ultrafiltration and subsequent poor compensatory mechanisms due to abnormal cardiac function or autonomic or baroreceptor failure. Pediatric patients are inherently at risk for IDH due to the added difficulty of determining and attaining an accurate dry weight. While frequent blood pressure monitoring, dialysate sodium profiling, ultrafiltration-guided blood volume monitoring, dialysate cooling, hemodiafiltration, and intradialytic mannitol and midodrine have been used to prevent IDH, they have not been extensively studied in pediatric population. Lack of large-scale studies on IDH in children makes it difficult to develop evidence-based management guidelines. Here, we aim to review IDH preventative strategies in the pediatric population and outlay recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup. Without strong evidence in the literature, our recommendations from the expert panel reflect expert opinion and serve as a valuable guide.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00467-018-4190-1" target="_blank" rel="noreferrer noopener">10.1007/s00467-018-4190-1</a>
2019
Bagga Arvind
Blood Pressure Monitoring
Blood volume monitoring
Bunchman Timothy
Chand Deepa
Children
Davenport Andrew
Department of Internal Medicine
Dialysate cooling
Germany)
Hothi Daljit
Intradialytic hypotension
June 2019 Update
Kapur Gaurav
Krishnappa Vinod
Lam Stephanie
Mannitol
McCulloch Mignon
Midodrine
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
Pediatric nephrology (Berlin
Pediatric nephrology (Berlin, Germany)
Raheja Hershita
Raina Rupesh
Schaefer Franz
Sethi Sidharth Kumar
Sodium profiling
Warady Bradley A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0178233" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0178233</a>
Pages
e0178233–e0178233
Issue
5
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of AKI in developing and developed countries: An international survey of pediatric dialysis modalities.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017
Subject
The topic of the resource
Humans; Child; Surveys and Questionnaires; *Developed Countries; *Developing Countries; Acute Kidney Injury/*therapy; Renal Dialysis/*methods
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Chauvin Abigail M; Bunchman Timothy; Askenazi David; Deep Akash; Ensley Michael J; Krishnappa Vinod; Sethi Sidharth Kumar
Description
An account of the resource
HYPOTHESIS: Acute kidney injury (AKI) is a common cause of morbidity and mortality worldwide, with a pediatric incidence ranging from 19.3% to 24.1%. Treatment of pediatric AKI is a source of debate in varying geographical regions. Currently CRRT is the treatment for pediatric AKI, but limitations due to cost and accessibility force use of adult equipment and other therapeutic options such as peritoneal dialysis (PD) and hemodialysis (HD). It was hypothesized that more cost-effective measures would likely be used in developing countries due to lesser resource availability. METHODS: A 26-question internet-based survey was distributed to 650 pediatric Nephrologists. There was a response rate of 34.3% (223 responses). The survey was distributed via pedneph and pcrrt email servers, inquiring about demographics, technology, resources, pediatric-specific supplies, and preference in renal replacement therapy (RRT) in pediatric AKI. The main method of analysis was to compare responses about treatments between nephrologists in developed countries and nephrologists in developing countries using difference-of-proportions tests. RESULTS: PD was available in all centers surveyed, while HD was available in 85.1% and 54.1% (p = 0.00), CRRT was available in 60% and 33.3% (p = 0.001), and SLED was available in 20% and 25% (p = 0.45) centers of developed and developing world respectively. In developing countries, 68.5% (p = 0.000) of physicians preferred PD to costlier therapies, while in developed countries it was found that physicians favored HD (72%, p = 0.00) or CRRT (24%, p = 0.041) in infants. CONCLUSIONS: Lack of availability of resources, trained physicians and funds often preclude standards of care in developing countries, and there is much development needed in terms of meeting higher global standards for treating pediatric AKI patients. PD remains the main modality of choice for treatment of AKI in infants in developing world.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0178233" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0178233</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Developed Countries
*Developing Countries
2017
Acute Kidney Injury/*therapy
Askenazi David
Bunchman Timothy
Chauvin Abigail M
Child
Deep Akash
Department of Internal Medicine
Ensley Michael J
Humans
Krishnappa Vinod
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
PloS one
Raina Rupesh
Renal Dialysis/*methods
Sethi Sidharth Kumar
Surveys and Questionnaires