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Text
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URL Address
<a href="http://doi.org/10.1016/s0304-3940(00)01142-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0304-3940(00)01142-3</a>
Pages
121–124
Issue
2
Volume
287
Dublin Core
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Title
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Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury.
Publisher
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Neuroscience letters
Date
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2000
2000-06
Subject
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*Antigens; *Avian Proteins; *Blood Proteins; Aging/*physiology; Animals; Basigin; CD; Cell Division/physiology; Hot Temperature; Hyperalgesia/pathology; Inbred F344; Membrane Glycoproteins/analysis; Microglia/chemistry/*cytology; Neoplasm; Posterior Horn Cells/*cytology; Rats; Sciatic Nerve/*injuries; Sciatica/pathology; Surface
Creator
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Stuesse S L; Cruce W L; Lovell J A; McBurney D L; Crisp T
Description
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Nerve injury may lead to chronic neuropathic pain syndromes. We determined whether the extent of central nervous system microglial activation that accompanies nerve injury is age dependent and correlated with behavioral manifestations of pain. We used the Bennett and Xie sciatic nerve chronic constriction injury model (Bennett, G.J., Xie, Y.-K., A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man, Pain, 33 (1998) 87-107) to induce neuropathic pain in three age cohorts of Fischer 344 FBNF1 hybrid rats (4-6, 14-16, and 24-26 months). Rats were assessed for thermal sensitivity (hyperalgesia) of their hind paws pre-injury (day 0) and up to 35 days post injury. On various days post injury, the L4-L5 levels of their spinal cords were reacted for localization of an antibody to OX-42, a marker for microlgia. OX-42 immunoreactivity (ir) was quantified by use of a Bioquant density analysis system. OX-42 ir was heavy in areas of sciatic nerve primary afferent terminations and in the motor columns of its neurons. Aging increases
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<a href="http://doi.org/10.1016/s0304-3940(00)01142-3" target="_blank" rel="noreferrer noopener">10.1016/s0304-3940(00)01142-3</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Antigens
*Avian Proteins
*Blood Proteins
2000
Aging/*physiology
Animals
Basigin
CD
Cell Division/physiology
Crisp T
Cruce W L
Department of Anatomy & Neurobiology
Hot Temperature
Hyperalgesia/pathology
Inbred F344
Lovell J A
McBurney D L
Membrane Glycoproteins/analysis
Microglia/chemistry/*cytology
NEOMED College of Medicine
Neoplasm
Neuroscience letters
Posterior Horn Cells/*cytology
Rats
Sciatic Nerve/*injuries
Sciatica/pathology
Stuesse S L
Surface