1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1038/347477a0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/347477a0</a> Pages 477–479 Issue 6292 Volume 347 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Two components of long-term potentiation induced by different patterns of afferent activation. Publisher An entity responsible for making the resource available Nature Date A point or period of time associated with an event in the lifecycle of the resource 1990 1990-10 Subject The topic of the resource 2-Amino-5-phosphonovalerate/*pharmacology; Afferent Pathways/physiology; Animals; Calcium/*physiology; Hippocampus/*physiology; In Vitro Techniques; Membrane Potentials; Memory/*physiology; N-Methyl-D-Aspartate/*physiology; Neuronal Plasticity; Receptors; Synaptic Transmission; Time Factors Creator An entity primarily responsible for making the resource Grover L M; Teyler T J Description An account of the resource Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1038/347477a0" target="_blank" rel="noreferrer noopener">10.1038/347477a0</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 1990 2-Amino-5-phosphonovalerate/*pharmacology Afferent Pathways/physiology Animals Calcium/*physiology Grover L M Hippocampus/*physiology In Vitro Techniques Membrane Potentials Memory/*physiology N-Methyl-D-Aspartate/*physiology Nature Neuronal Plasticity Receptors Synaptic Transmission Teyler T J Time Factors Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/hipo.450040602" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hipo.450040602</a> Pages 623–634 Issue 6 Volume 4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Multideterminant role of calcium in hippocampal synaptic plasticity. Publisher An entity responsible for making the resource available Hippocampus Date A point or period of time associated with an event in the lifecycle of the resource 1994 1994-12 Subject The topic of the resource Animals; Calcium/*physiology; Hippocampus/drug effects/*physiology; Humans; Neuronal Plasticity/drug effects/*physiology; Synapses/drug effects/*physiology Creator An entity primarily responsible for making the resource Teyler T J; Cavus I; Coussens C; DiScenna P; Grover L; Lee Y P; Little Z Description An account of the resource Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca(2+)-dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage-dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/hipo.450040602" target="_blank" rel="noreferrer noopener">10.1002/hipo.450040602</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 1994 Animals Calcium/*physiology Cavus I Coussens C DiScenna P Grover L Hippocampus Hippocampus/drug effects/*physiology Humans Lee Y P Little Z Neuronal Plasticity/drug effects/*physiology Synapses/drug effects/*physiology Teyler T J