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Text
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URL Address
<a href="http://doi.org/10.1111/j.1478-3231.2010.02295.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1478-3231.2010.02295.x</a>
Pages
1103–1114
Issue
8
Volume
30
Dublin Core
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Title
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Resveratrol and liver disease: from bench to bedside and community.
Publisher
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Liver international : official journal of the International Association for the Study of the Liver
Date
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2010
2010-09
Subject
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Acetaminophen/metabolism; Anti-Inflammatory Agents; Antioxidants/therapeutic use; Carbon Tetrachloride/metabolism; Cytokines/metabolism; Ethanol/metabolism; Free Radicals/metabolism; Glutathione/metabolism; Hepatocytes/drug effects/pathology; Humans; Liver Diseases/*drug therapy/epidemiology; NF-kappa B/antagonists & inhibitors; Non-Steroidal/therapeutic use; Resveratrol; Stilbenes/pharmacokinetics/*pharmacology/therapeutic use/toxicity
Creator
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Bishayee Anupam; Darvesh Altaf S; Politis Themos; McGory Robb
Description
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Liver diseases incorporate several maladies, which can range from benign histological changes to serious life-threatening conditions. These may include inborn metabolic disease, primary and metastatic cancers, alcoholic cirrhosis, viral hepatitis and drug-induced hepatotoxicity. Liver disease remains a major cause of morbidity and mortality with significant economic and social costs. Several novel approaches are currently being studied which may provide a better therapeutic outcome. The use of naturally occurring phytochemicals, some of them obtained from dietary sources, in the amelioration of illness have recently gained considerable popularity. These agents, having anti-oxidant and anti-inflammatory properties, provide a safe and effective means of ameliorating chronic disease. Resveratrol, a grape polyphenol, has shown considerable promise as a therapeutic agent in the treatment of the aforementioned liver ailments. Several studies have highlighted the hepatoprotective properties of resveratrol. Resveratrol has been shown to prevent hepatic damage because of free radicals and inflammatory cytokines, induce anti-oxidant enzymes and elevate glutathione content. Resveratrol has also been shown to modulate varied signal transduction pathways implicated in liver diseases. This review critically examines the current preclinical in vitro and in vivo studies on the preventive and therapeutic effects of resveratrol in liver diseases. The review highlights the pharmacological mechanisms involved in mediating the aforementioned effects. Toxicity, pharmacokinetics and clinical bioavailability of resveratrol are also reviewed in this article. The challenges involved, future directions and novel approaches such as site-specific drug delivery in the use of resveratrol for the prevention and treatment of liver disease are also discussed.
Identifier
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<a href="http://doi.org/10.1111/j.1478-3231.2010.02295.x" target="_blank" rel="noreferrer noopener">10.1111/j.1478-3231.2010.02295.x</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Acetaminophen/metabolism
Anti-Inflammatory Agents
Antioxidants/therapeutic use
Bishayee Anupam
Carbon Tetrachloride/metabolism
Cytokines/metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Ethanol/metabolism
Free Radicals/metabolism
Glutathione/metabolism
Hepatocytes/drug effects/pathology
Humans
Liver Diseases/*drug therapy/epidemiology
Liver international : official journal of the International Association for the Study of the Liver
McGory Robb
NEOMED College of Pharmacy
NF-kappa B/antagonists & inhibitors
Non-Steroidal/therapeutic use
Politis Themos
Resveratrol
Stilbenes/pharmacokinetics/*pharmacology/therapeutic use/toxicity