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Text
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URL Address
<a href="http://doi.org/10.1002/ccd.27996" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ccd.27996</a>
Pages
E277-E286
Issue
5
Volume
93
ISSN
1522-726X
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Update Year & Number
June2020SubmittedList
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Outcomes with drug-coated balloons in small-vessel coronary artery disease.
Publisher
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Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Date
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2019
2019-04-01
Subject
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Female; Humans; Male; Aged; Middle Aged; Treatment Outcome; Risk Factors; Risk Assessment; Randomized Controlled Trials as Topic; Cardiac Catheters; Coated Materials Biocompatible; drug-coated balloons; drug-eluting balloons; Drug-Eluting Stents; small-vessel disease coronary disease; Angioplasty Balloon Coronary/adverse effects/instrumentation/mortality; Cardiovascular Agents/administration & dosage/adverse effects; Coronary Artery Disease/diagnostic imaging/mortality/therapy; Coronary Restenosis/epidemiology; Observational Studies as Topic
Creator
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Megaly M; Rofael M; Saad M; Rezq A; Kohl LP; Kalra A; Shishehbor M; Soukas P; Abbott JD; Brilakis ES
Description
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BACKGROUND: Percutaneous coronary intervention (PCI) of small-vessel coronary artery disease (SVD) is associated with increased risk of restenosis. The use of drug-coated balloons (DCBs) in SVD has received limited study. OBJECTIVES: To assess the outcomes of DCB in the treatment of SVD compared with the standard of care. METHODS: We performed a meta-analysis of all studies published between January 2000 and September 2018 reporting the outcomes of DCB versus other modalities in the treatment of de novo SVD. RESULTS: Seven studies with 1,824 patients (1,938 lesions) were included (four randomized controlled trials and three observational studies). During a mean follow-up of 14.5 ± 10 months, DCBs were associated with a similar risk of target lesion revascularization (TLR) (OR: 0.99, 95% CI: 0.54, 1.84, P = 97) and major adverse cardiovascular events (MACE) (OR: 0.86, 95% CI: 0.51, 1.45, P = 0.57) compared with drug-eluting stents (DES). During a mean follow-up of 7 ± 1.5 months, DCBs were associated with a significantly lower risk of TLR (OR: 0.19, 95% CI 0.04-0.88, P = 0.03) and binary restenosis (OR: 0.17, 95% CI 0.08-0.37, P = <0.00001) compared with noncoated balloon angioplasty. CONCLUSION: The use of DCBs in SVD is associated with comparable outcomes when compared with DES and favorable outcomes when compared with balloon angioplasty.
Identifier
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<a href="http://doi.org/10.1002/ccd.27996" target="_blank" rel="noreferrer noopener">10.1002/ccd.27996</a>
PMID: 30489687
Rights
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© 2018 Wiley Periodicals, Inc.
Format
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journalArticle
2019
Abbott JD
Aged
Angioplasty Balloon Coronary/adverse effects/instrumentation/mortality
Brilakis ES
Cardiac Catheters
Cardiovascular Agents/administration & dosage/adverse effects
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Cleveland Clinic Akron General Hospital
Coated Materials Biocompatible
Coronary Artery Disease/diagnostic imaging/mortality/therapy
Coronary Restenosis/epidemiology
Department of Internal Medicine
drug-coated balloons
drug-eluting balloons
Drug-Eluting Stents
Female
Humans
journalArticle
June2020SubmittedList
Kalra A
Kohl LP
Male
Megaly M
Middle Aged
NEOMED College of Medicine
Observational Studies as Topic
Randomized Controlled Trials as Topic
Rezq A
Risk Assessment
Risk Factors
Rofael M
Saad M
Shishehbor M
small-vessel disease coronary disease
Soukas P
Treatment Outcome