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Text
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URL Address
<a href="http://doi.org/10.1016/j.drudis.2016.10.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.drudis.2016.10.007</a>
Pages
352–365
Issue
2
Volume
22
Dublin Core
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Title
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Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases.
Publisher
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Drug Discovery Today
Date
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2017
2017-02
Subject
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Animals; Cardiovascular Diseases/drug therapy/*enzymology; Humans; Lipoprotein Lipase/chemistry/*metabolism; Metabolic Diseases/drug therapy/*enzymology
Creator
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Geldenhuys Werner J; Lin Li; Darvesh Altaf S; Sadana Prabodh
Description
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Although statins and other pharmacological approaches have improved the management of lipid abnormalities, there exists a need for newer treatment modalities especially for the management of hypertriglyceridemia. Lipoprotein lipase (LPL), by promoting hydrolytic cleavage of the triglyceride core of lipoproteins, is a crucial node in the management of plasma lipid levels. Although LPL expression and activity modulation is observed as a pleiotropic action of some the commonly used lipid lowering drugs, the deliberate development of drugs targeting LPL has not occurred yet. In this review, we present the biology of LPL, highlight the LPL modulation property of currently used drugs and review the novel emerging approaches to target LPL.
Identifier
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<a href="http://doi.org/10.1016/j.drudis.2016.10.007" target="_blank" rel="noreferrer noopener">10.1016/j.drudis.2016.10.007</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Animals
Cardiovascular Diseases/drug therapy/*enzymology
Darvesh Altaf S
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drug Discovery Today
Geldenhuys Werner J
Humans
Lin Li
Lipoprotein Lipase/chemistry/*metabolism
Metabolic Diseases/drug therapy/*enzymology
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana Prabodh