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Text
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URL Address
<a href="http://doi.org/10.3390/molecules22060917" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/molecules22060917</a>
Issue
6
Volume
22
Dublin Core
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Title
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Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.
Publisher
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Molecules (Basel, Switzerland)
Date
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2017
2017-06
Subject
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Humans; Animals; Protein Binding; Signal Transduction; atherosclerosis; *Drug Discovery; *Ligands; Adenosine/metabolism; cardiac death; Cardiovascular Diseases/drug therapy/metabolism; Cardiovascular System/metabolism; Hydrogen Bonding; Molecular Structure; myocardial infarction; Structure-Activity Relationship; vascular tone; Receptors; Models; Molecular; Purinergic P1/*chemistry/*metabolism
Creator
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Geldenhuys Werner J; Hanif Ahmad; Yun June; Nayeem Mohammed A
Description
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Cardiovascular diseases remain the number one diseases affecting patients' morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural changes in structure translate into ligand potency and efficacy. Adenosine receptors represent a novel therapeutic target for development of treatment options treating a wide variety of diseases, including vascular disease and obesity.
Identifier
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<a href="http://doi.org/10.3390/molecules22060917" target="_blank" rel="noreferrer noopener">10.3390/molecules22060917</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*drug discovery
*Ligands
2017
Adenosine/metabolism
Animals
Atherosclerosis
Cardiac death
Cardiovascular Diseases/drug therapy/metabolism
Cardiovascular System/metabolism
Department of Integrative Medical Sciences
Geldenhuys Werner J
Hanif Ahmad
Humans
Hydrogen Bonding
Models
Molecular
Molecular Structure
Molecules (Basel, Switzerland)
myocardial infarction
Nayeem Mohammed A
NEOMED College of Medicine
Protein Binding
Purinergic P1/*chemistry/*metabolism
Receptors
Signal Transduction
Structure-Activity Relationship
Vascular tone
Yun June