Stem Cell Therapies For Coronary Collateral Growth In Zucker Obese Fatty Rats: Redox Modulator Mitoneet As A Therapeutic Target
Arteriogenesis; Cardiovascular System & Cardiology; cells; Metabolic syndrome; Mitochondria; oxidative stress; Stem
Logan S; Geldenhuys W; Yin L Y; Carroll R; Stevanov K; Enrick M; Ohanyan V; Chilian W
Circulation
2013
2013-11
Journal Article or Conference Abstract Publication
n/a
Failure Of Regenerative Cell-based Therapy To Stimulate Coronary Collateral Growth In A Rat Model Of Metabolic Syndrome
Arteriogenesis; Cardiovascular System & Cardiology; Collateral circulation; Metabolic; oxidative stress; Stem cell therapy; syndrome
Logan S; Chilian W M; Ohanyan V A; Stevanov K; Enrick M; Kolz C L; Yin L Y
Circulation
2012
2012-11
Journal Article or Conference Abstract Publication
n/a
Transient Ischemic Dilation: A New Perspective Utilizing Cardiac Mri
Cardiovascular System & Cardiology
Lisko J C; Nicoloff N; Mikolich B; Dhingra A; Mikolich J R
Journal of the American College of Cardiology
2015
2015-03
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/s0735-1097(15)61316-x" target="_blank" rel="noreferrer noopener">10.1016/s0735-1097(15)61316-x</a>
Left Ventractilar Hypertrophy In Hypertensive Patients: A Reliable Diagnosis?
Cardiac MRI; Cardiovascular System & Cardiology; Echocardiography; Hypertension; Hypertrophy
Lisko J; Mikolich J R; Boniface N C; Hegde V; Tandon N; Mikolich B
Circulation
2013
2013-11
Journal Article or Conference Abstract Publication
n/a
Inhibition Of Angiopoietin-like 3 Expression Is A Potential Mechanism Of Activation Of Lipoprotein Lipase And Of Lipid Lowering By Metformin
Cardiovascular System & Cardiology; Drugs; Hematology; Hyperlipidemia; Lipases
Lin L; Burke J R; Geldenhuys W J; Sadana P
Arteriosclerosis Thrombosis and Vascular Biology
2017
2017-05
Journal Article or Conference Abstract Publication
n/a
Foxo1 And Tgf Beta 1 Signaling Inhibit Cholesterol 7 Alpha-hydroxylase Gene Expression And Bile Acid Synthesis In High Fat Diet Induced Diabetes
Cardiovascular System & Cardiology
Li T G; Chiang J Y
Circulation
2008
2008-10
Journal Article or Conference Abstract Publication
n/a
Gemifloxacin Once Daily For 7 Days Compared To Amoxicillin/clavulanic Acid Thrice Daily For 10 Days For The Treatment Of Community-acquired Pneumonia Of Suspected Pneumococcal Origin
adults; antimicrobial resistance; Cardiovascular System & Cardiology; community-acquired pneumonia; fluoroquinolone; gemifloxacin; guidelines; levofloxacin; management; pneumococcal pneumonia; Respiratory System; streptococcus-pneumoniae; surveillance; therapy; trovafloxacin; united-states
Context: Community-acquired pneumonia (CAP) is common among adults and contributes considerably to morbidity and mortality. Objective: To compare the safety and efficacy of gemifloxacin to high-dose amoxicillin/clavulanate for the treatment of CAP of suspected pneumococcal origin. Design: Randomized, multicentre, double-blind, double-dummy, parallel group Phase III study. Setting and participants: From September 1998 to July 1999, 324 patients with CAP were randomized at 102 centers in France, Poland and the Republic of South Africa. Intervention: Patients were double-blind randomized to receive either oral gemifloxacin 320 mg once daily for 7 days or oral amoxicillin/clavulanate 1 g/1 25 mg three times daily for 10 days. Main outcome measures: The main outcome measures were clinical, bacteriotogical, and radiological responses at the end of therapy (day 12-14) and follow-up (day 24-30) visits. Results: In 228 PP patients, clinical resolution at follow-up was 88.7% for 7-day gemifloxacin and 87.6% for 10-day amoxicillin/clavulanate [95% CI, -7.3, 9.5]. In 249 PP patients, clinical resolution at end of therapy was 95.3% for 7-day gemifloxacin vs. 90.1% for 10-day amoxicillin/clavutanate [95% Cl, -1.2, 11.7]. Bacteriologic response rates for the PP patients at end of therapy were 96.3% for 7-day gernifloxacin and 91.8% for the amoxicillin/clavulanate group [95% Cl, -4.7, 13.6]. Bacteriologic response rates at follow-up were 87.2% for 7-day gernifloxacin and 89.1% for the amoxicillin/clavulanate group [95% CI, -15.0, 11.2]. Specifically gernifloxacin eradicated 95.7% of Streptococcus pneumoniae including penicillin and macrolide resistant strains. Radiological response rates for the PP patients at end of therapy were 89.1% for 7-day gemifloxacin and 87.6% for the amoxicillin/clavulanate group. The most frequently reported drug-retated events were in the gernifloxacin group, diarrhea (6.0%) and rash (3.0%) and in the amoxicillin/clavulanate group, diarrhea (11.1%) and fungal infection, vaginitis and vomiting (each 2.0%). Overall there were statistically fewer withdrawals due to tack of therapeutic effect in the gemifloxacin group compared with the amoxicillin/clavulanate cohort, (95% Cl, -8.8;0.6; P = 0.03). Conclusion: Gemifloxacin 320 mg once daily for 7 days was found to be clinically, bacteriologically, and radiologically as effective as 10 days of amoxicillin/clavulanate 1 g/125 mg three times daily for the treatment of suspected pneumococcal CAR (C) 2004 Elsevier Ltd. All rights reserved.
Leophonte P; File T; Feldman C
Respiratory Medicine
2004
2004-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.rmed.2004.04.007" target="_blank" rel="noreferrer noopener">10.1016/j.rmed.2004.04.007</a>
Biphasic Modulation Of The Mitochondrial Electron Transport Chain In Myocardial Ischemia And Reperfusion
Cardiovascular System & Cardiology; cytochrome-c-oxidase; energy-metabolism; injury; nadh dehydrogenase; oxidative modification; oxygen-free-radicals; Physiology; postischemic myocardium; protein biosynthesis; rat-heart mitochondria; reactive oxygen species; transfer complex-i; translational control
Lee HL, Chen CL, Yeh ST, Zweier JL, Chen YR. Biphasic modulation of the mitochondrial electron transport chain in myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol 302: H1410-H1422, 2012. First published January 20, 2012; doi: 10.1152/ajpheart.00731.2011.-Mitochondrial electron transport chain (ETC) is the major source of reactive oxygen species during myocardial ischemia-reperfusion (I/R) injury. Ischemic defect and reperfusion-induced injury to ETC are critical in the disease pathogenesis of postischemic heart. The properties of ETC were investigated in an isolated heart model of global I/R. Rat hearts were subjected to ischemia for 30 min followed by reperfusion for 1 h. Studies of mitochondrial function indicated a biphasic modulation of electron transfer activity (ETA) and ETC protein expression during I/R. Analysis of ETAs in the isolated mitochondria indicated that complexes I, II, III, and IV activities were diminished after 30 min of ischemia but increased upon restoration of flow. Immunoblotting analysis and ultrastructural analysis with transmission electron microscopy further revealed marked downregulation of ETC in the ischemic heart and then upregulation of ETC upon reperfusion. No significant difference in the mRNA expression level of ETC was detected between ischemic and postischemic hearts. However, reperfusion-induced ETC biosynthesis in myocardium can be inhibited by cycloheximide, indicating the involvement of translational control. Immunoblotting analysis of tissue homogenates revealed a similar profile in peroxisome proliferator-activated receptor-gamma coactivator-1 alpha expression, suggesting its essential role as an upstream regulator in controlling ETC biosynthesis during I/R. Significant impairment caused by ischemic and postischemic injury was observed in the complexes I-III. Analysis of NADH ferricyanide reductase activity indicated that injury of flavoprotein subcomplex accounts for 50% decline of intact complex I activity from ischemic heart. Taken together, our findings provide a new insight into the molecular mechanism of I/R-induced mitochondrial dysfunction.
Lee H L; Chen C L; Yeh S T; Zweier J L; Chen Y R
American Journal of Physiology-Heart and Circulatory Physiology
2012
2012-04
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1152/ajpheart.00731.2011" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00731.2011</a>
Evaluation Of Embolic Protection Devices For Fat Emboli Prevention
Cardiovascular System & Cardiology; Surgery
Background: Patients with acutely treated femoral shaft fractures with reamed intramedullary nailing are at risk for acute respiratory distress syndrome due to liberation of bone marrow fat particles that travel to the lung and cause damage to the parenchyma. The purpose of this study was to demonstrate: (1) the ability of clinically applicable embolic protection devices to capture such particles; (2) how such a device affects cardiopulmonary function after reamed intramedullary nailing; and (3) evaluation of lung pathology to determine whether filtration affects pulmonary embolic load. Methods: A total of 12 canines were anesthetized, and hemodynamic monitoring was established. Carotid embolic protection devices were introduced into the iliac vein, and ipsilateral intramedullary reaming and nailing was performed. Cardiopulmonary parameters were recorded at timed intervals up to 60 minutes after the procedure. The control group (n = 4) was compared with groups treated with Accunet (n = 4) and Spider (n = 4) filters. A blinded histopathological review was performed on lung specimens to determine the average number of emboli per section and to measure the area (mm(2)) of embolic load by digital image analysis. Results: Gross inspection of the embolic protection devices showed the presence of bone marrow debris. A significant change was observed in pH levels (control = -0.052, filters = +0.005; P < .05) within the 60 minutes after intramedullary nailing. Serum bicarbonate (meq/dL) values were noted to have similar changes of -2.7 and -1.8 at 10 and 60 minutes, whereas the experimental group was +0.6 and +0.8 at the same time intervals (P = .01 and .0004, respectively). Pulmonary measurements for pO(2) and oxygen saturation were analogous to the serum parameters with decreases in the control group in comparison with the filter groups. The mean numbers of emboli and area measurements of embolic load were significantly reduced in the filter group (all P < .01). Conclusions: Embolic protection devices were effective in capturing embolic debris from reamed intramedullary nailing of lower extremity long bones and demonstrated a protective effect on pulmonary function and significantly decreased the number and size of emboli in the lung. Based on these findings, patients with long bone fractures at risk for pulmonary complications and acute respiratory distress syndrome could benefit from the placement of embolic protection devices prior to intramedullary fixation. While this study utilized filtration devices designed for carotid embolic protection, further study is warranted to determine optimal filter design in this setting.
Lanzinger W; Caldwell J; Schoenfeld A; Horne W; Sloan P; Stakleff K S; Zink J; Netzley R; Wright D
Journal of Vascular Surgery-Venous and Lymphatic Disorders
2013
2013-01
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.jvsv.2012.07.012" target="_blank" rel="noreferrer noopener">10.1016/j.jvsv.2012.07.012</a>
Mitochondrial Oxidative Stress Negatively Impacts Endothelial Function In The Metabolic Syndrome
Cardiovascular System & Cardiology
Kiyooka T; Rocic P; Wilson G; Shokolenko I; Chilian W M
Circulation
2007
2007-10
Journal Article or Conference Abstract Publication
n/a
Basis Of Impaired Coronary Metabolic Dilation In Obesity And Insulin Resistance
Cardiovascular System & Cardiology
Kiyooka T; Ohanyan V; Dobson J G; Fenton R A; Balmadani S; Chilian W M
Circulation
2008
2008-10
Journal Article or Conference Abstract Publication
n/a
Impaired Coronary Metabolic Dilation In Metabolic Syndrome
Cardiovascular System & Cardiology; Physiology
Kiyooka T; Nikaidoh A; Takikawa M; Okamoto N; Kasai T; Oikawa K; Chilian W M
Journal of Vascular Research
2009
2009
Journal Article or Conference Abstract Publication
n/a
Ibuprofen Reduces The Lung Lymph-flow Changes Associated With Inhalation Injury
Cardiovascular System & Cardiology
Kimura R; Traber L; Herndon D; Niehaus G; Flynn J; Traber D L
Circulatory Shock
1988
1988-03
Journal Article or Conference Abstract Publication
n/a
Cost-effectiveness Of Warfarin Management In Atrial Fibrillation: Comparison Of Cardiologist And Primary Care Physician Practice Patterns
Cardiovascular System & Cardiology
Khandhar S J; Tjia J; Amorn A M; Mikolich J R
Circulation
2004
2004-05
Journal Article or Conference Abstract Publication
n/a
The Role Of Amadori-glycation In High Density Lipoprotein Dysfunction And Oxidative Stress In Patients With Diabetes
Apolipoproteins; Atherosclerosis; Cardiovascular System & Cardiology; Hematology; Insulin resistance
Kasumov T; Golizeh M; Lee K; Ilchenko S; Wang S H; Smith J; Kashyap S
Arteriosclerosis Thrombosis and Vascular Biology
2017
2017-05
Journal Article or Conference Abstract Publication
n/a
Mitochondrial Reductive Stress Induced By Over-expression Of Sod2 Enhances Cardiac Function
Cardiovascular System & Cardiology; Hypertrophy; Mitochondria; oxidative stress; Redox; Super oxide
Kang P T; Chen C L; Luther D J; Ohanyan V; Meszaros J G; Chilian W M; Chen Y R
Circulation
2013
2013-11
Journal Article or Conference Abstract Publication
n/a
Defective Glutathione Reductase Results In Systolic Dysfunction Associated With Impaired Mitochondrial Integrity, Increased Uncoupling Respiration, And Enhanced S-glutathionylation Of Complex I
Cardiovascular System & Cardiology; Enzyme inhibitors; Mitochondria; oxidative stress; Redox; Systole
Kang P T; Chen C L; Guarini G; Chen Y R
Circulation
2011
2011-11
Journal Article or Conference Abstract Publication
n/a
Oxidant Stress-induced Protein Thiyl Radical Is Associated To Enhancement Of Complex I S-glutathionylation In The Enos(-/-) Murine Heart
Cardiovascular System & Cardiology; Mitochondria; Myocardium; nitric-oxide synthase; Redox; Super oxide
Kang P T; Chen C L; Chen Y R
Circulation
2012
2012-11
Journal Article or Conference Abstract Publication
n/a
Early Up-regulation Of Myocardial Cxcr4 Expression Is Critical For Cardiac Improvement With Chemical Preconditioning In Acute Myocardial Infarction
Cardiac regeneration; Cardiovascular System & Cardiology; heart failure; Myocardial infarction
Kamath M; Kiedrowski M; Weber K; Forudi F; Penn M S; Dong F
Circulation
2013
2013-11
Journal Article or Conference Abstract Publication
n/a
Complication Of Cardiac Resuscitation
Cardiovascular System & Cardiology
Jeong Y G; Caccamo L P
American Heart Journal
1975
1975
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/0002-8703(75)90238-0" target="_blank" rel="noreferrer noopener">10.1016/0002-8703(75)90238-0</a>
Tissue Specificity In Hormone Induced Fibroblast Collagen Type I Production In Heart, Coronary Arteries And Aorta
Cardiovascular System & Cardiology
Jenkins C; Milsted A; Doane K; Meszaros G; Ely D
Hypertension
2005
2005-10
Journal Article or Conference Abstract Publication
n/a
Angiotensin Type I Receptor Blockade In Conjunction With Enhanced Akt Activation Restores Coronary Collateral Growth In The Metabolic Syndrome
Cardiovascular System & Cardiology; coronary artery occlusion; endothelial-cells; inhibition; ischemia-induced angiogenesis; kinase; mediated angiogenesis; nitric-oxide synthase; pathway; phosphorylation; Physiology; rat; smooth-muscle-cells; transient
Jadhav R, Dodd T, Smith E, Bailey E, DeLucia AL, Russell JC, Madison R, Potter B, Walsh K, Jo H, Rocic P. Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome. Am J Physiol Heart Circ Physiol 300: H1938-H1949, 2011. First published February 18, 2011; doi:10.1152/ajpheart.00282.2010.-We have previously demonstrated that Akt was required for repetitive ischemia (RI)-induced coronary collateral growth (CCG) in healthy rats but was not activated by RI in the metabolic syndrome (JCR:LA-cp rats) where CCG was impaired. Here we hypothesized that failure of angiotensin type I receptor (AT(1)R) blockers to restore Akt activation is a key determinant of their inability to completely restore CCG in the metabolic syndrome. Therefore, we investigated whether adenovirus-mediated delivery of constitutively active Akt (MyrAkt-Adv.) in conjunction with AT(1)R blockade (candesartan) was able to restore RI-induced CCG in JCR:LA-cp rats. Successful myocardial MyrAkt-Adv delivery was confirmed by a >80% transduction efficiency and an approximately fourfold increase in Akt expression and activation. CCG was assessed by myocardial blood flow measurements in the normal and collateral-dependent zones. MyrAkt-Adv alone significantly increased RI-induced CCG in JCR:LA-cp rats (similar to 30%), but it completely restored CCG in conjunction with administration of candesartan. In contrast, dominant negative Akt (DN-Akt-Adv) reversed the beneficial effect of candesartan on CCG in JCR:LA-cp rats. We conclude that optimal restoration of coronary collateral growth in JCR:LA-cp rats requires a combination of AT(1)R blockade with constitutive Akt activation. These findings may carry implications for metabolic syndrome patients in need of coronary revascularization.
Jadhav R; Dodd T; Smith E; Bailey E; DeLucia A L; Russell J C; Madison R; Potter B; Walsh K; Jo H J; Rocic P
American Journal of Physiology-Heart and Circulatory Physiology
2011
2011-05
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1152/ajpheart.00282.2010" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00282.2010</a>
Bile Acid Receptor Activation Ameliorates Metabolic Disorders By Differentially Activating Fxr Or Tgr5
Cardiovascular System & Cardiology; Hematology; Ligands; Lipids
Jadhav K S; Xu Y; Zhang Y Q
Arteriosclerosis Thrombosis and Vascular Biology
2017
2017-05
Journal Article or Conference Abstract Publication
n/a
Effects Of Exercise On C-reactive Protein In Healthy Patients And In Patients With Heart Disease: A Meta-analysis
Biological; body-composition; Cardiovascular System & Cardiology; cardiovascular-disease; Coronary disease; coronary-artery-disease; exercise; Heart disease; induced weight-loss; Inflammation; inflammatory markers; life-style intervention; marker c-reactive protein; Nursing; obese postmenopausal women; physical-activity; randomized controlled trial; Respiratory System; risk-factors; time
Decreases in circulating hsCRP have been associated with increased physical activity and exercise training, although the ability of exercise interventions to reduce hsCRP and which individuals benefit the most remains unclear. This meta-analysis evaluates the ability of exercise to reduce hsCRP levels in healthy individuals and in individuals with heart disease. A systematic review and meta-analysis was conducted that included exercise interventions trials from 1995 to 2012. Forty-three studies were included in the final analysis for a total of 3575 participants. Exercise interventions significantly reduced hsCRP (standardized mean difference -0.53 mg/L; 95% CI, -0.74 to -0.33). Results of sub-analysis revealed no significant difference in reductions in hsCRP between healthy adults and those with heart disease (p =.20). Heterogeneity between studies could not be attributed to age, gender, intervention length, intervention type, or inclusion of diet modification. Exercise interventions reduced hsCRP levels in adults irrespective of the presence of heart disease. (c) 2016 Elsevier Inc. All rights reserved.
Hammonds T L; Gathright E C; Goldstein C M; Penn M S; Hughes J W
Heart & Lung
2016
2016-05
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.hrtlng.2016.01.009" target="_blank" rel="noreferrer noopener">10.1016/j.hrtlng.2016.01.009</a>
Detecting Dna Synthesis Of Neointimal Formation After Catheter Balloon Injury In Gk And In Wistar Rats: Using 5-ethynyl-2 '-deoxyuridine
alkynes; arterial injury; balloon injury; Cardiovascular System & Cardiology; carotid-artery; Catheter; cell-cycle progression; click chemistry; diabetes-mellitus; diabetes-mellitus; DNA synthesis; EdU; eluting stents; Endocrinology & Metabolism; in-vitro; mammalian target; Neointimal formation; PCNA; proliferation; terminal
Background: Neointimal formation plays an important role in the pathogenesis of coronary restenosis after percutaneous coronary intervention (PCI), especially in patients with diabetes mellitus. Recently, some studies have shown that 5-ethynyl-2'-deoxyuridine (EdU) incorporation can serve as a novel alternative to the 5-bromo-2'-deoxyuridine (BrdU) antibody detection method for detection of DNA synthesis in regenerating avian cochlea, chick embryo and the adult nervous system. However, few studies have been performed to assess the suitability of EdU for detecting DNA synthesis in vascular neointima. Methods: The carotid artery balloon injury model was established in Goto-Kakizaki (GK) and Wistar rats. A Cell-Light (TM) EdU Kit was used to detect EdU-labeled cell nuclei of common carotid arteries at day 7 after catheter balloon injury. Different methods of injecting EdU were tested. The protein levels of proliferating cell nuclear antigen (PCNA) and p-Akt (Ser473), as well as the mRNA levels of PCNA were evaluated by Western blotting and quantitative real-time PCR (qRT-PCR), respectively. Immunohistochemical staining was also employed to visualize PCNA-positive cells. Results: At day 7 after catheter balloon injury, far more EdU-positive and PCNA-positive cells were observed in GK rats. When comparing groups that received different EdU doses, it was found that the percentage of EdU-positive cells at a dose of 100 mg/kg body weight was than at doses of 25 mg/kg and 50 mg/kg. The number of positive cells was significantly higher in the repeated injection group compared to the single injection group. Further, after balloon injury DNA synthesis in GK rats was more notable than in Wistar rats. Neointimal formation in GK rats was more obvious than in Wistar rats. The protein levels of PCNA and p-Akt (Ser473) and the mRNA levels of PCNA were increased in injured rats as compared to uninjured rats, and were significantly higher in GK rats than in Wistar rats. Conclusion: By intraperitoneal injections of EdU at a dose of 100 mg/kg three times, EdU incorporation can detect carotid arterial DNA synthesis caused by neointimal formation in GK rats and Wistar rats at day 7 after balloon injury by the EdU click reaction quickly and effectively. Moreover, more obvious DNA synthesis in the vascular neointima could be observed in GK rats than in Wistar rats.
Guo J S; Li D Y; Bai S R; Xu T D; Zhou Z M; Zhang Y B
Cardiovascular Diabetology
2012
2012-12
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1186/1475-2840-11-150" target="_blank" rel="noreferrer noopener">10.1186/1475-2840-11-150</a>
Coronary Microvascular Dysfunction Is Linked To Altered Tprv1 Channels Function In Metabolic Syndrome
Cardiovascular System & Cardiology
Guarini G; Ohanyan V A; Chilian W M; Bratz I N
European Heart Journal
2010
2010-09
Journal Article or Conference Abstract Publication
n/a
Targeting Mitochondrial Dna To Reduce Consequences Of Oxidative Stress: Role In The Prevention Of The Diabetic Cardiomyopathy
arrhythmias; Cardiovascular System & Cardiology; Coronary circulation; Coronary microcirculation; heart failure; Mitochondrial energetics; oxidative stress; Type 2 Diabetes
Guarini G; Kolz C L; Pung Y F; Ohanyan V A; Yin L Y; Bratz I N; Marzilli M; Chilian W M
Circulation
2011
2011-11
Journal Article or Conference Abstract Publication
n/a
Repair Of Mitochondrial Dna Oxidative Damage Restores Coronary Metabolic Dilation In Diabetes
Cardiovascular System & Cardiology
Guarini G; Kolz C; Pung Y F; Marzilli M; Chilian W M
European Heart Journal
2011
2011-08
Journal Article or Conference Abstract Publication
n/a
Role Of Mitochondrial Function And Mitochondrial Dna Integrity In Coronary Metabolic Dilation
arrhythmias; Cardiovascular System & Cardiology; Coronary circulation; Coronary microcirculation; energetics; heart failure; Mitochondrial
Guarini G; Kolz C; Ohanyan V A; Bratz I N; Yin L Y; Shokolenko I; Wilson G L; Chilian W M
Circulation
2010
2010-11
Journal Article or Conference Abstract Publication
n/a
Measurement Of Reactive Oxygen Species, Reactive Nitrogen Species, And Redox-dependent Signaling In The Cardiovascular System: A Scientific Statement From The American Heart Association
acute myocardial-infarction; AHA Scientific Statements; Cardiovascular System & Cardiology; coronary-artery-disease; free radicals; Hematology; ischemia-reperfusion injury; liquid-chromatography; low-density-lipoprotein; measurements; nitric-oxide synthase; nitrogen species; oxidants; oxidative stress; performance; peroxides; protein-tyrosine phosphatases; reactive; reactive oxygen species; tandem mass-spectrometry; vascular smooth-muscle
Reactive oxygen species and reactive nitrogen species are biological molecules that play important roles in cardiovascular physiology and contribute to disease initiation, progression, and severity. Because of their ephemeral nature and rapid reactivity, these species are difficult to measure directly with high accuracy and precision. In this statement, we review current methods for measuring these species and the secondary products they generate and suggest approaches for measuring redox status, oxidative stress, and the production of individual reactive oxygen and nitrogen species. We discuss the strengths and limitations of different methods and the relative specificity and suitability of these methods for measuring the concentrations of reactive oxygen and reactive nitrogen species in cells, tissues, and biological fluids. We provide specific guidelines, through expert opinion, for choosing reliable and reproducible assays for different experimental and clinical situations. These guidelines are intended to help investigators and clinical researchers avoid experimental error and ensure high-quality measurements of these important biological species.
Griendling K K; Touyz R M; Zweier J L; Dikalov S; Chilian W; Chen Y R; Harrison D G; Bhatnagar A; Amer Heart Assoc Council Basic
Circulation Research
2016
2016-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1161/res.0000000000000110" target="_blank" rel="noreferrer noopener">10.1161/res.0000000000000110</a>
Obstructive Coronary Atherosclerosis And Ischemic Heart Disease: An Elusive Link!
angina; artery-disease; atherosclerosis; Cardiovascular System & Cardiology; clinical presentation; follow-up; fractional flow reserve; Ischemic heart disease; medical therapy; multifactorial; myocardial-infarction; prognostic value; reactive protein-levels; revascularization; risk-factors; stable
Marzilli M; Merz C N B; Boden W E; Bonow R O; Capozza P G; Chilian W M; DeMaria A N; Guarini G; Huqi A; Morrone D; Patel M R; Weintraub W S
Journal of the American College of Cardiology
2012
2012-09
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.jacc.2012.02.082" target="_blank" rel="noreferrer noopener">10.1016/j.jacc.2012.02.082</a>
Pulmonary Hemodynamic-responses During Superior Mesenteric-artery Occlusion
Cardiovascular System & Cardiology
Maron M B; Borchelt M D
Circulatory Shock
1983
1983
Journal Article or Conference Abstract Publication
n/a
Risk Factors For Upper Extremity Venous Thrombosis Associated With Peripherally Inserted Central Venous Catheters
Cardiovascular System & Cardiology; chronic kidney-disease; deep-vein thrombosis; pH; PICC lines; Prophylaxis; retrospective analysis; risk-factors; thromboembolism; thrombophlebitis; trauma; Upper extremity venous thrombosis
Marnejon T; Angelo D; Abu Abdou A; Gemmel D
Journal of Vascular Access
2012
2012-04
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.5301/jva.5000039" target="_blank" rel="noreferrer noopener">10.5301/jva.5000039</a>
Feasibility Of Percutaneous Extraction Of Transvenous Defibrillator Leads
Cardiovascular System & Cardiology
Maloney J D; Wilkoff B L; Smith H J; Zhu W X
Circulation
1995
1995-10
Journal Article or Conference Abstract Publication
n/a
Economic Effect Of Third-party Payor Pre-authorization Policy For Nuclear Stress Perfusion Imaging
Cardiovascular imaging; Cardiovascular System & Cardiology; Health economics; Perfusion imaging; Stress echocardiography
Malik B R; Mikolich J R; Lisko J; Dhingra A; Mikolich B
Circulation
2013
2013-11
Journal Article or Conference Abstract Publication
n/a
Effect Of Third Party Payor Pre-authorization Policy On Concordance Of Nuclear Stress Perfusion Imaging And Coronary Arteriography
Cardiovascular System & Cardiology
Malik B; Mikolich J R; Dhingra A; Lisko J; Mikolich B
Journal of the American College of Cardiology
2013
2013-03
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/s0735-1097(13)61548-x" target="_blank" rel="noreferrer noopener">10.1016/s0735-1097(13)61548-x</a>
Interference With Akt Signaling In Dyslipidemia Diminishes Myocardial Infarction And Promotes Survival By Inhibiting Oxidative Stress
Cardiovascular System & Cardiology
Ma L N; Kerr B A; West X Z; Malinin N L; Weber M E; Ding L; Somanath P R; Penn M S; Podrez E A; Byzova T V
Heart
2012
2012-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1136/heartjnl-2012-302920a.154" target="_blank" rel="noreferrer noopener">10.1136/heartjnl-2012-302920a.154</a>
Long-term Tamoxifen (tmx)-treatment Enhances Endothelium-dependent Nitric Oxide (no) And Constrictor Prostanoid (pg) Function In Female Rat Aorta
Cardiovascular System & Cardiology
Fulton C T; Freeman E J; Stallone J N
Circulation
1999
1999-11
Journal Article or Conference Abstract Publication
n/a
Global Position Paper On Cardiovascular Regenerative Medicine
acute myocardial-infarction; bone-marrow-cells; Cardiovascular System & Cardiology; colony-stimulating factor; controlled clinical-trial; critical; function; ischemic-heart failure; left-ventricular; limb ischemia; nonischemic dilated cardiomyopathy; pluripotent stem-cells; randomized controlled-trial
Fernandez-Aviles F; Sanz-Ruiz R; Climent A M; Badimon L; Bolli R; Charron D; Fuster V; Janssens S; Kastrup J; Kim H S; Luscher T F; Martin J F; Menasche P; Simari R D; Stone G W; Terzic A; Willerson J T; Wu J C; Broughton K; DiFede D L; Dimmeler S; Madonna R; Penn M S; Sussman M A; Sluijter J P G; Wollert K C; Balkan W; Chamuleau S; Fernandez-Santos M E; Goliasch G; Gyongyosi M; Hare J M; Tompkins B A; Winkler J; Bayes-Genis A; Henry T D; Taylor D A; Lerman A; Pelacho B; Prosper F; Perin E C; Pompilio G; Gersh B; Bartunek J; Duckers E; Ferdinandy P; Losordo D W; Sanchez P L; Sherman W; Wojakowski W; Zeiher A; Roncalli J; Mathur A; Crea F; D'Amario D; Povsic T J; Traverse J; Yla-Herttuala S; Alliance Tactics Transnational; Basic Res Subcomm; Translational Res Subcomm; Challenges Cardiovasc Regenerative; Tissue Engn Subcomm; Delivery Navigation Tracking; Clinical Trials Subcomm; Regulatory; Funding Strategie
European Heart Journal
2017
2017-09
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1093/eurheartj/ehx248" target="_blank" rel="noreferrer noopener">10.1093/eurheartj/ehx248</a>
Role Of Genetic Polymorphisms Of Ion Channels In The Pathophysiology Of Coronary Microvascular Dysfunction And Ischemic Heart Disease
artery-disease; atherosclerosis; Atrial fibrillation; Cardiovascular System & Cardiology; Coronary microcirculation; dysfunction; endothelial; Endothelium; gene; Genetic polymorphisms; Ion channels; Ischemic heart disease; k-atp channels; kir6.2; late sodium current; nitric-oxide; sensitive potassium channels; smooth-muscle; type-2 diabetes-mellitus; vascular
Fedele F; Mancone M; Chilian W M; Severino P; Canali E; Logan S; De Marchis M L; Volterrani M; Palmirotta R; Guadagni F
Basic Research in Cardiology
2013
2013-11
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1007/s00395-013-0387-4" target="_blank" rel="noreferrer noopener">10.1007/s00395-013-0387-4</a>