1
40
9
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/en.131.2.964" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/en.131.2.964</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
964-969
Issue
2
Volume
131
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Dublin Core
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Title
A name given to the resource
QUANTIFICATION OF VASOACTIVE-INTESTINAL-PEPTIDE IMMUNOREACTIVITY IN THE ANTERIOR-PITUITARY GLANDS OF INTACT MALE AND FEMALE, OVARIECTOMIZED, AND ESTRADIOL BENZOATE-TREATED RATS
Publisher
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Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-08
Subject
The topic of the resource
serotonin; expression; Endocrinology & Metabolism; estrogen; release; polypeptide; vip; hypothalamus; antisera; passive-immunization; prolactin secretion
Creator
An entity primarily responsible for making the resource
Carrillo A J; Phelps C J
Description
An account of the resource
There are considerable data suggesting that vasoactive intestinal peptide (VIP) is involved in the regulation of PRL secretion; however, the role and cell of origin of anterior pituitary VIP remain to be determined. Immunocytochemical (ICC) studies have generally failed to detect VIP-immunoreactive (IR) cells in the pituitary of the untreated rat, although VIP-IR cells have been observed in the pituitaries of hypothyroid or estrogen-treated rats. This study was designed to examine the cellular distribution and tissue content of VIP in the anterior pituitary gland of rats under selected endocrine conditions known to alter the rates of PRL and VIP synthesis and secretion. To this end, anterior pituitary VIP and PRL content (ICC and RIA) and serum PRL levels were determined in ovariectomized (OVX) and OVX rats 3 days after treatment with 7 or 70-mu-g estradiol benzoate (EB). For comparison, pituitary VIP and PRL content (ICC and RIA) and serum PRL levels in untreated male and diestrous female rats were determined. Immunostaining for VIP was accomplished using a newly developed primary antiserum. Significant numbers of VIP-IR cells per 5-mu-m section were found in the anterior pituitary glands of all animals examined (275 +/- 33 in diestrous to 481 +/- 103 cells in male rats). VIP was not colocalized with PRL in any of the pituitaries regardless of steroid treatment or sex. Furthermore, the number of VIP-IR cells per pituitary gland was not significantly correlated with sex or EB treatment. Treatment with 70-mu-g, but not 7-mu-g, EB significantly increased the pituitary content of VIP and serum PRL levels compared to those after ovariectomy. However, both EB treatments resulted in a significant increase in pituitary PRL content compared to that in untreated OVX rats. Pituitaries from male rats had several-fold more VIP and less PRL content than pituitaries from diestrous rats. These data show that 1) in contrast to previous ICC studies, VIP-IR cells are readily detected in the anterior pituitary of intact male and female and OVX as well as EB-treated rats; 2) VIP is localized to cells other than lactotrophs, regardless of the steroid background; and 3) marked changes in anterior pituitary VIP content are not accompanied by changes in VIP-IR cell number.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/en.131.2.964" target="_blank" rel="noreferrer noopener">10.1210/en.131.2.964</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
antisera
Carrillo A J
Endocrinology
Endocrinology & Metabolism
estrogen
expression
Hypothalamus
Journal Article or Conference Abstract Publication
passive-immunization
Phelps C J
polypeptide
prolactin secretion
release
serotonin
VIP
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0303-7207(89)90170-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0303-7207(89)90170-6</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
103-109
Issue
1
Volume
65
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
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Title
A name given to the resource
OBESITY-RELATED AND SEX-RELATED ALTERATIONS IN GROWTH-HORMONE MESSENGER-RNA LEVELS
Publisher
An entity responsible for making the resource available
Molecular and Cellular Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-08
Subject
The topic of the resource
Cell Biology; Endocrinology & Metabolism
Creator
An entity primarily responsible for making the resource
Ahmad I; Steggles A W; Carrillo A J; Finkelstein J A
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0303-7207(89)90170-6" target="_blank" rel="noreferrer noopener">10.1016/0303-7207(89)90170-6</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1989
Ahmad I
Carrillo A J
Cell Biology
Endocrinology & Metabolism
Finkelstein J A
Journal Article or Conference Abstract Publication
Molecular and cellular endocrinology
Steggles A W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0303-7207(89)90170-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0303-7207(89)90170-6</a>
Pages
103–109
Issue
1
Volume
65
Dublin Core
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Title
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Obesity- and sex-related alterations in growth hormone messenger RNA levels.
Publisher
An entity responsible for making the resource available
Molecular and cellular endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-08
Subject
The topic of the resource
Female; Male; Animals; Sex Characteristics; Rats; Nucleic Acid Hybridization; DNA Probes; Obesity/*genetics/metabolism; Prolactin/genetics; Somatomedins/*genetics; RNA; Messenger/metabolism; Zucker
Creator
An entity primarily responsible for making the resource
Ahmad I; Steggles A W; Carrillo A J; Finkelstein J A
Description
An account of the resource
The secretion of growth hormone (GH) is abnormal in genetically obese Zucker rats. Measurements of pulsatile GH release and circulating GH levels in lean (Fa/?) and obese (fa/fa) rats have shown that both are reduced in the latter. We have studied pituitary GH gene expression in order to understand the role of GH synthesis in this abnormality. Obese animals have lower pituitary GH mRNA levels than lean controls. Within each genotype a sex difference was observed with the female animals having lower GH mRNA levels than the males. It is unlikely that the GH abnormality is due to a generalized pituitary defect because prolactin mRNA levels were the same in all four groups of rats.
Identifier
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<a href="http://doi.org/10.1016/0303-7207(89)90170-6" target="_blank" rel="noreferrer noopener">10.1016/0303-7207(89)90170-6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Ahmad I
Animals
Carrillo A J
DNA Probes
Female
Finkelstein J A
Male
Messenger/metabolism
Molecular and cellular endocrinology
Nucleic Acid Hybridization
Obesity/*genetics/metabolism
Prolactin/genetics
Rats
RNA
Sex Characteristics
Somatomedins/*genetics
Steggles A W
Zucker
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/endo-128-1-131" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/endo-128-1-131</a>
Pages
131–138
Issue
1
Volume
128
Dublin Core
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Title
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Preferential increase in pituitary prolactin versus vasoactive intestinal peptide as a function of estradiol benzoate dose in the ovariectomized rat.
Publisher
An entity responsible for making the resource available
Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Animals; Brain/drug effects/*metabolism; Dose-Response Relationship; Drug; Estradiol/*pharmacology; Female; Inbred Strains; Organ Specificity; Ovariectomy; Pituitary Gland/drug effects/*metabolism; Prolactin/blood/*metabolism; Rats; Thyrotropin/blood/metabolism; Vasoactive Intestinal Peptide/*metabolism
Creator
An entity primarily responsible for making the resource
Carrillo A J; Doherty P C; Guan X B; Sturtevant J R; Walro D G
Description
An account of the resource
Vasoactive intestinal peptide (VIP) is synthesized in various tissues, including the anterior pituitary gland, where it may stimulate the release of PRL. Because estrogen plays a central role in the regulation of PRL, it becomes important to determine the effects of this steroid on both pituitary VIP and PRL. To study this, pituitary VIP and PRL and plasma PRL were assayed in ovariectomized rats after treatment with estradiol benzoate (EB; 0.007, 0.07, 0.7, 7 or 70 microgram/rat). Pituitary and plasma TSH were also determined as well as VIP content in the medial basal hypothalamus, suprachiasmatic region, cerebral cortex, and jejunum. Oil-treated rats served as controls. Injection of 0.7 or 7 microgram EB resulted in a significant increase in pituitary PRL without changing plasma PRL levels or pituitary VIP content compared to values in the control group. Only treatment with 70 microgram EB produced a significant increase in both pituitary VIP and PRL as well as in plasma PRL compared to control values. EB treatment at any of the doses used had no significant effect on pituitary and plasma TSH or VIP content in any of the other tissues examined. These data show that pituitary PRL and VIP are differentially regulated in response to estrogen. The increases in pituitary VIP and basal plasma PRL after treatment with the highest dose of EB suggest that pituitary VIP may be involved in the development of estrogen-induced hyperprolactinemia. These data also show that the regulations of pituitary VIP and TSH are independent of each other in the estrogen-treated rat.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/endo-128-1-131" target="_blank" rel="noreferrer noopener">10.1210/endo-128-1-131</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Brain/drug effects/*metabolism
Carrillo A J
Doherty P C
Dose-Response Relationship
Drug
Endocrinology
Estradiol/*pharmacology
Female
Guan X B
Inbred Strains
Organ Specificity
Ovariectomy
Pituitary Gland/drug effects/*metabolism
Prolactin/blood/*metabolism
Rats
Sturtevant J R
Thyrotropin/blood/metabolism
Vasoactive Intestinal Peptide/*metabolism
Walro D G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/endo.131.2.1639033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/endo.131.2.1639033</a>
Pages
964–969
Issue
2
Volume
131
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Quantification of vasoactive intestinal peptide immunoreactivity in the anterior pituitary glands of intact male and female, ovariectomized, and estradiol benzoate-treated rats.
Publisher
An entity responsible for making the resource available
Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-08
Subject
The topic of the resource
*Ovariectomy; Animals; Anterior/*chemistry/drug effects/metabolism; Diestrus; Estradiol/*pharmacology; Female; Immunohistochemistry; Inbred Strains; Male; Pituitary Gland; Prolactin/blood/metabolism; Rats; Vasoactive Intestinal Peptide/*analysis/metabolism
Creator
An entity primarily responsible for making the resource
Carrillo A J; Phelps C J
Description
An account of the resource
There are considerable data suggesting that vasoactive intestinal peptide (VIP) is involved in the regulation of PRL secretion; however, the role and cell of origin of anterior pituitary VIP remain to be determined. Immunocytochemical (ICC) studies have generally failed to detect VIP-immunoreactive (IR) cells in the pituitary of the untreated rat, although VIP-IR cells have been observed in the pituitaries of hypothyroid or estrogen-treated rats. This study was designed to examine the cellular distribution and tissue content of VIP in the anterior pituitary gland of rats under selected endocrine conditions known to alter the rates of PRL and VIP synthesis and secretion. To this end, anterior pituitary VIP and PRL content (ICC and RIA) and serum PRL levels were determined in ovariectomized (OVX) and OVX rats 3 days after treatment with 7 or 70 micrograms estradiol benzoate (EB). For comparison, pituitary VIP and PRL content (ICC and RIA) and serum PRL levels in untreated male and diestrous female rats were determined. Immunostaining for VIP was accomplished using a newly developed primary antiserum. Significant numbers of VIP-IR cells per 5-microns section were found in the anterior pituitary glands of all animals examined (275 +/- 33 in diestrous to 481 +/- 103 cells in male rats). VIP was not colocalized with PRL in any of the pituitaries regardless of steroid treatment or sex. Furthermore, the number of VIP-IR cells per pituitary gland was not significantly correlated with sex or EB treatment. Treatment with 70 micrograms, but not 7 micrograms, EB significantly increased the pituitary content of VIP and serum PRL levels compared to those after ovariectomy. However, both EB treatments resulted in a significant increase in pituitary PRL content compared to that in untreated OVX rats. Pituitaries from male rats had several-fold more VIP and less PRL content than pituitaries from diestrous rats. These data show that 1) in contrast to previous ICC studies, VIP-IR cells are readily detected in the anterior pituitary of intact male and female and OVX as well as EB-treated rats; 2) VIP is localized to cells other than lactotrophs, regardless of the steroid background; and 3) marked changes in anterior pituitary VIP content are not accompanied by changes in VIP-IR cell number.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/endo.131.2.1639033" target="_blank" rel="noreferrer noopener">10.1210/endo.131.2.1639033</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ovariectomy
1992
Animals
Anterior/*chemistry/drug effects/metabolism
Carrillo A J
Diestrus
Endocrinology
Estradiol/*pharmacology
Female
Immunohistochemistry
Inbred Strains
Male
Phelps C J
Pituitary Gland
Prolactin/blood/metabolism
Rats
Vasoactive Intestinal Peptide/*analysis/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0303-7207(94)90168-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0303-7207(94)90168-6</a>
Pages
183–191
Issue
2
Volume
105
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.
Publisher
An entity responsible for making the resource available
Molecular and cellular endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-11
Subject
The topic of the resource
5-Hydroxytryptophan/pharmacology; alpha-Methyltyrosine; Animals; Anterior/*chemistry/drug effects/metabolism; Blotting; Bromocriptine/pharmacology; Gene Expression Regulation/drug effects/physiology; Genetic; Haloperidol/pharmacology; Ketanserin/pharmacology; Male; Messenger/*analysis/genetics; Methiothepin/pharmacology; Methoxydimethyltryptamines/pharmacology; Methyltyrosines/pharmacology; Northern; Pituitary Gland; Prolactin/analysis/*genetics/metabolism; Quipazine/pharmacology; Rats; RNA; Serotonin/*physiology; Sprague-Dawley; Time Factors; Transcription; Vasoactive Intestinal Peptide/analysis/*genetics/metabolism
Creator
An entity primarily responsible for making the resource
Signs S A; Liu B; Wolford J; Carrillo A J
Description
An account of the resource
These studies examined the contribution of serotonin (5-HT) to the control of prolactin (PRL) and vasoactive intestinal peptide (VIP) messenger RNA expression in rat anterior pituitary. Daily injection of rats with the biosynthetic precursor to serotonin, 5-hydroxytryptophan (5-HTP; 25 mg/kg, q.i.d.), resulted on day 5 in a 50% increase in the expression of PRL mRNA in the pituitary while at the same time reducing the levels of both the 1.0 and 1.7 kb VIP mRNA transcripts. Co-treatment of rats with 5-HTP plus the catecholamine biosynthesis inhibitor, alpha-methyl-tyrosine (alpha-MT; 150 mg/kg, q.d. x 2 days), or the dopamine receptor antagonist haloperidol (1.25 mg/kg, b.i.d. x 5 days), resulted in increases in pituitary PRL message levels that were greater than those observed with either anti-dopaminergic agent alone. In contrast, 5-HTP was unable to reverse the inhibition of PRL mRNA expression caused by treatment with the dopamine receptor agonist bromocriptine (2.5 mg/kg, b.i.d. x 5 days). Neither alpha-MT, haloperidol nor bromocriptine had a significant effect on pituitary VIP mRNA expression. Administration of the direct-acting 5-HT receptor agonist quipazine (5 mg/kg, b.i.d.) for 14 consecutive days caused a significant increase in pituitary PRL mRNA levels on day 1 and reached a plateau of 90% above control levels on days 7 and 14. VIP mRNA levels rose significantly on day 1 of quipazine treatment but thereafter fell to a minimum of 22% (1.0 kb) and 52% (1.7 kb) of control by day 14.(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0303-7207(94)90168-6" target="_blank" rel="noreferrer noopener">10.1016/0303-7207(94)90168-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
5-Hydroxytryptophan/pharmacology
alpha-Methyltyrosine
Animals
Anterior/*chemistry/drug effects/metabolism
Blotting
Bromocriptine/pharmacology
Carrillo A J
Gene Expression Regulation/drug effects/physiology
Genetic
Haloperidol/pharmacology
Ketanserin/pharmacology
Liu B
Male
Messenger/*analysis/genetics
Methiothepin/pharmacology
Methoxydimethyltryptamines/pharmacology
Methyltyrosines/pharmacology
Molecular and cellular endocrinology
Northern
Pituitary Gland
Prolactin/analysis/*genetics/metabolism
Quipazine/pharmacology
Rats
RNA
Serotonin/*physiology
Signs S A
Sprague-Dawley
Time Factors
Transcription
Vasoactive Intestinal Peptide/analysis/*genetics/metabolism
Wolford J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0169-328x(93)90070-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0169-328x(93)90070-6</a>
Pages
36–40
Issue
1
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Para-chlorophenylalanine treatment inhibits the expression of vasoactive intestinal peptide messenger RNA in rat anterior pituitary.
Publisher
An entity responsible for making the resource available
Brain research. Molecular brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-01
Subject
The topic of the resource
alpha-Methyltyrosine; Animals; Anterior/*drug effects/metabolism; Chemical; Depression; Dopamine/metabolism; Fenclonine/*pharmacology; Gene Expression Regulation/drug effects; Male; Messenger/*biosynthesis; Methyltyrosines/pharmacology; Pituitary Gland; Prolactin/metabolism; Rats; RNA; Serotonin/metabolism; Sprague-Dawley; Tryptophan Hydroxylase/antagonists & inhibitors; Vasoactive Intestinal Peptide/*biosynthesis/genetics
Creator
An entity primarily responsible for making the resource
Signs S A; Dluzen D E; Carrillo A J
Description
An account of the resource
Adult male Sprague-Dawley rats were treated with para-chlorophenylalanine (pCPA) or alpha-methyl tyrosine (alpha-MT) to study the effect of serotonin or catecholamine depletion on the expression of vasoactive intestinal peptide (VIP) messenger RNA in the anterior pituitary. Single injections of pCPA (300 mg/kg) for two consecutive days resulted on the third day in a dramatic depletion of serotonin in the medial basal hypothalamus, and a significant reduction in the pituitary content of VIP mRNA (1.0 and 1.7 kb). The effect of pCPA on VIP mRNA appeared to be relatively specific for the anterior pituitary since VIP message levels in the cerebral cortex did not decrease. alpha-MT treatment, (150 mg/kg) for 2 consecutive days, reduced dopamine concentrations in the MBH but had no significant effect on pituitary VIP levels. In a time-course study, hypothalamic serotonin and pituitary VIP mRNA levels were significantly depressed 1-3 days after initiation of pCPA treatment; however, 12 days after pCPA treatment, serotonin concentrations in the hypothalamus approached control values and pituitary VIP mRNA content increased an average of 2-fold over control levels in an apparent rebound effect. pCPA-treated rats injected i.p. twice a day with
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0169-328x(93)90070-6" target="_blank" rel="noreferrer noopener">10.1016/0169-328x(93)90070-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
alpha-Methyltyrosine
Animals
Anterior/*drug effects/metabolism
Brain research. Molecular brain research
Carrillo A J
Chemical
Depression
Dluzen D E
Dopamine/metabolism
Fenclonine/*pharmacology
Gene Expression Regulation/drug effects
Male
Messenger/*biosynthesis
Methyltyrosines/pharmacology
Pituitary Gland
Prolactin/metabolism
Rats
RNA
Serotonin/metabolism
Signs S A
Sprague-Dawley
Tryptophan Hydroxylase/antagonists & inhibitors
Vasoactive Intestinal Peptide/*biosynthesis/genetics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(93)90910-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(93)90910-f</a>
Pages
281–284
Issue
2
Volume
613
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-06
Subject
The topic of the resource
Adrenal Glands/anatomy & histology; Animals; Anterior/*physiology; Arcuate Nucleus of Hypothalamus/*physiology; Drinking Behavior; Hypothalamo-Hypophyseal System/*physiology; Male; Median Eminence/*physiology; Organ Size; Pituitary Gland; Pituitary Gland/anatomy & histology; Prolactin/blood/metabolism; Rats; Sprague-Dawley; Testis/anatomy & histology; Time Factors; Vasoactive Intestinal Peptide/*metabolism
Creator
An entity primarily responsible for making the resource
Carrillo A J; Dluzen D E
Description
An account of the resource
This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median eminence (ARC-ME) region in adult male rats. Fifteen days later, there was a significant reduction in pituitary mass, adrenal and testicular weight and an increase in water consumption and serum prolactin levels indicating the elimination of hypothalamic influence on the pituitary gland in the ARC-ME group when compared to controls. Anterior pituitary VIP content was also significantly reduced in the lesion group. These data suggest that the hypothalamus is involved in the regulation of pituitary VIP.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(93)90910-f" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(93)90910-f</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Adrenal Glands/anatomy & histology
Animals
Anterior/*physiology
Arcuate Nucleus of Hypothalamus/*physiology
Brain research
Carrillo A J
Dluzen D E
Drinking Behavior
Hypothalamo-Hypophyseal System/*physiology
Male
Median Eminence/*physiology
Organ Size
Pituitary Gland
Pituitary Gland/anatomy & histology
Prolactin/blood/metabolism
Rats
Sprague-Dawley
Testis/anatomy & histology
Time Factors
Vasoactive Intestinal Peptide/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jcb.240430106" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcb.240430106</a>
Pages
59–66
Issue
1
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Developmental changes in levels of growth hormone mRNA in Zucker rats.
Publisher
An entity responsible for making the resource available
Journal of cellular biochemistry
Date
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1990
1990-05
Subject
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Aging/*metabolism; Animals; Blotting; Glyceraldehyde-3-Phosphate Dehydrogenases/genetics; Growth Hormone/blood/*genetics; Immunoblotting; Male; Messenger/*metabolism; Northern; Obesity/*genetics; Prolactin/genetics; Rats; RNA; Zucker
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Ahmad I; Steggles A W; Carrillo A J; Finkelstein J A
Description
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Levels of pituitary growth hormone (GH) messenger RNA (mRNA) were compared in groups of genetically obese (fa/fa) and lean (Fa/-) littermate male Zucker rats at four different ages, 3, 5, 9, and 11 weeks, in order to determine the earliest age at which a difference between the two groups could be detected. No difference was seen in three-week-old animals. Five weeks of age was the earliest time at which the level of GH mRNA was significantly decreased in the obese rats; this decrease was present at all subsequent ages. Mean serum growth hormone levels were lower in obese animals at all ages, but the differences were not statistically significant because of the large individual variation associated with the pulsatile nature of GH release. The earliest occurrence of differences in GH mRNA level is later than some of the obesity associated abnormalities present in adipose tissue. The earliest time of the GH mRNA differences can be associated with the time when decreased protein deposition is initially seen in the obese rats. Because of this association, decreased GH mRNA may enhance the development of obesity.
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<a href="http://doi.org/10.1002/jcb.240430106" target="_blank" rel="noreferrer noopener">10.1002/jcb.240430106</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Aging/*metabolism
Ahmad I
Animals
Blotting
Carrillo A J
Finkelstein J A
Glyceraldehyde-3-Phosphate Dehydrogenases/genetics
Growth Hormone/blood/*genetics
Immunoblotting
Journal of cellular biochemistry
Male
Messenger/*metabolism
Northern
Obesity/*genetics
Prolactin/genetics
Rats
RNA
Steggles A W
Zucker