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Text
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URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90402-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90402-4</a>
Pages
267–271
Issue
2
Volume
36
Dublin Core
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Title
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Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.
Publisher
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Pharmacology, biochemistry, and behavior
Date
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1990
1990-06
Subject
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Male; Animals; Rats; Drug Administration Schedule; Drug Tolerance; Psychotropic Drugs/*pharmacology; Haloperidol/pharmacology; Alkaloids/*pharmacology; *Discrimination (Psychology)/drug effects; Catha; Domperidone/pharmacology; Phenylpropanolamine/antagonists & inhibitors/*pharmacology; Plant Extracts/analysis; Inbred Strains
Creator
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Pehek E A; Schechter M D
Description
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The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this effect developed and dissipated rapidly. Thus, different dose-response curves were generated depending upon whether cathine or vehicle was administered the day before testing. The development of tolerance also shortened cathine's time course of action and enhanced the ability of haloperidol to antagonize the cathine cue. These results suggest caution in interpreting effects produced by intermittent drug injection schedules.
Identifier
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<a href="http://doi.org/10.1016/0091-3057(90)90402-4" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90402-4</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)/drug effects
1990
Alkaloids/*pharmacology
Animals
Catha
Domperidone/pharmacology
Drug Administration Schedule
Drug Tolerance
Haloperidol/pharmacology
Inbred Strains
Male
Pehek E A
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/antagonists & inhibitors/*pharmacology
Plant Extracts/analysis
Psychotropic Drugs/*pharmacology
Rats
Schechter M D