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Text
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URL Address
<a href="http://doi.org/10.1002/ar.21363" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ar.21363</a>
Pages
1461–1471
Issue
9
Volume
294
Dublin Core
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Title
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Fetal lung epithelial ion channels relocate in the cell membrane during late gestation.
Publisher
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Anatomical record (Hoboken, N.J. : 2007)
Date
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2011
2011-09
Subject
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Animals; Blotting; Caveolin 1/*metabolism; Cell Membrane/*metabolism; Cl transport; Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism; distal lung fluid absorption; Epithelial Sodium Channels/*metabolism; Epithelium/embryology/*metabolism; Female; fetal lung development; Fetus/*metabolism; Gestational Age; Guinea Pigs; IL-1beta; Immunoprecipitation; Interleukin-1beta/metabolism; Ion Channels/metabolism; Lung/embryology/*metabolism; Na transport; Western
Creator
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Beard LaMonta L; Li Tianbo; Hu Yang; Folkesson Hans G
Description
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Near the end of gestation, the direction of ion and fluid flow across the alveolar epithelium rapidly changes from secretion to absorption. Thus, the relative cell membrane location of epithelial Na channels (ENaCs) and cystic fibrosis transmembrane regulator (CFTR) Cl channels during late fetal lung development and after maternal interleukin-1beta (IL-1beta) pretreatment was the focus of our study. Western blot analysis after sucrose gradient separation of caveolin-1-(Cav-1)-rich membrane regions (CRR) and Cav-1-poor membrane (non-CRR) revealed primary CRR ENaC localization at gestation day (GD) 61 in guinea pigs. Correlating with the natural induction of distal lung fluid absorption, ENaC appeared in the non-CRR cell membrane regions at GD68. Conversely, CFTR was present in the non-CRR cell membrane regions at GD61 and in the CRRs at GD68.
Identifier
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<a href="http://doi.org/10.1002/ar.21363" target="_blank" rel="noreferrer noopener">10.1002/ar.21363</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Anatomical record (Hoboken, N.J. : 2007)
Animals
Beard LaMonta L
Blotting
Caveolin 1/*metabolism
Cell Membrane/*metabolism
Cl transport
Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism
distal lung fluid absorption
Epithelial Sodium Channels/*metabolism
Epithelium/embryology/*metabolism
Female
fetal lung development
Fetus/*metabolism
Folkesson Hans G
Gestational Age
Guinea Pigs
Hu Yang
IL-1beta
Immunoprecipitation
Interleukin-1beta/metabolism
Ion Channels/metabolism
Li Tianbo
Lung/embryology/*metabolism
Na transport
Western