Browse Items (68 total)
- Tags: Cell Line
A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors.
Tags: *Gene Expression Profiling, *Gene Expression Regulation, 2015, Blotting, Breast Neoplasms/genetics/pathology, Cell Line, Char Jessica E, Chen Xin, ErbB-2/*genetics/metabolism, Franke Anna-Clara, Gene Regulatory Networks, Homeodomain Proteins/genetics/metabolism, Humans, Jia Zhenyu, Jones Frank E, McClelland Michael, MCF-7 Cells, Men Bozhao, Mercola Dan, Nanog Homeobox Protein, Neoplastic, Neoplastic Stem Cells/metabolism, Octamer Transcription Factor-3/genetics/metabolism, Oncotarget, Rahmatpanah Farah B, Receptor, Regulon/*genetics, Reverse Transcriptase Polymerase Chain Reaction, RNA Polymerase II/metabolism, SOXB1 Transcription Factors/genetics/metabolism, Tumor, Tumor Microenvironment/genetics, Western
A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.
Tags: 2007, Bile Acids and Salts/metabolism, Carcinoma, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology, Gastroenterology, Genetic/drug effects/*physiology, Hepatocellular/*metabolism/pathology, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/drug effects/*metabolism/pathology, Humans, Hydroxamic Acids/pharmacology, Li Tiangang, Liver Neoplasms/*metabolism/pathology, Messenger/metabolism, NEOMED College of Medicine, RNA, Signal Transduction/physiology, Smad3 Protein/metabolism, Transcription, Transforming Growth Factor beta1/*metabolism, Tumor
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
Tags: *Gene Expression Regulation, 2006, Aged, Amino Acid Motifs, Bile Acids and Salts/metabolism, Cell Line, Cell Nucleus/metabolism, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*chemistry/*genetics, Cultured/metabolism, Department of Integrative Medical Sciences, Enzymologic, Female, Genes, Genetic, Gluconeogenesis, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/metabolism/*physiology, Hepatocytes/metabolism, Homeodomain Proteins/metabolism/*physiology, Humans, Immunoprecipitation, Li Tiangang, Liver/metabolism, Luciferases/metabolism, Male, Messenger/metabolism, Middle Aged, NEOMED College of Medicine, Phosphoenolpyruvate Carboxykinase (ATP)/metabolism, Plasmids/metabolism, Protein Structure, Reporter, Response Elements, Reverse Transcriptase Polymerase Chain Reaction, RNA, Small Interfering/metabolism, Song Kwang-Hoon, Tertiary, The Journal of biological chemistry, Time Factors, Transcription, Transcriptional Activation, Transfection, Tumor Suppressor Proteins, Two-Hybrid System Techniques
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Tags: 2016, Adapala R K, Animals, Calcium Signaling/genetics, Cappelli H C, Carcinoma, Cell Line, Cell Proliferation/drug effects, Chilian W M, Cisplatin/administration & dosage, Department of Integrative Medical Sciences, Dudley A C, Endothelium, Gene Expression Regulation, Ghosh K, Humans, Ingber D E, Keshamouni V, Klagsbrun M, Leucine/administration & dosage/analogs & derivatives, Lewis Lung/drug therapy/*genetics/pathology, Meszaros J G, Mice, NEOMED College of Medicine, Neoplastic/drug effects, Neovascularization, Oncogene, Paruchuri S, Pathologic/drug therapy/*genetics/pathology, Sulfonamides/administration & dosage, Thodeti C K, Thoppil R J, TRPV Cation Channels/agonists/biosynthesis/*genetics, Tumor, Vascular Endothelial Growth Factor A/genetics, Vascular/drug effects/*pathology
Antitumor effect of novel gallium compounds and efficacy of nanoparticle-mediated gallium delivery in lung cancer.
Tags: 2012, Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics, Biocompatible Materials/administration & dosage/chemistry/pharmacokinetics, Cell Line, Cell Survival/drug effects, Coordination Complexes/*administration & dosage/chemistry/pharmacokinetics, Department of Pharmaceutical Sciences, Drug Carriers/administration & dosage/chemistry, Drug Stability, Endocytosis/drug effects, Gallium/*administration & dosage/chemistry/pharmacokinetics, Hemolysis/drug effects, Humans, Journal of biomedical nanotechnology, Lung Neoplasms/*drug therapy/metabolism, Materials Testing, Membrane Potential, Mitochondrial/drug effects, Nanoparticles/*administration & dosage/chemistry, NEOMED College of Pharmacy, Oyewumi Moses O, Particle Size, Platelet Aggregation/drug effects, Reactive Oxygen Species/metabolism, Transferrin/chemistry/pharmacology, Tumor, Wehrung Daniel
Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles.
Tags: *Lethal Dose 50, 2013, Adenocarcinoma/*drug therapy/pathology, Animals, Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity, Bi Lipeng, Cell Line, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Stability, Drug Tolerance, Gallium/*administration & dosage/pharmacokinetics/*toxicity, Geldenhuys Werner J, Humans, Journal of biomedical nanotechnology, Metabolic Clearance Rate, Mice, Nanocapsules/*administration & dosage/chemistry/*toxicity, NEOMED College of Pharmacy, Nude, Organ Specificity, Oyewumi Moses O, Tissue Distribution, Treatment Outcome, Triglycerides/chemistry, Tumor, Wehrung Daniel
Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.
Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko
BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.
Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Tags: 2009, Butadienes/pharmacology, Carcinoma, Cell Line, Chenodeoxycholic Acid/*pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cytoplasmic and Nuclear/metabolism/physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Fibroblast Growth Factor, Fibroblast Growth Factors/drug effects/*physiology, Gene Expression/drug effects, Hepatocellular/metabolism, Hepatocytes/metabolism, Hepatology (Baltimore, Md.), Humans, Isoxazoles/pharmacology, Li Tiangang, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, NEOMED College of Medicine, Nitriles/pharmacology, Owsley Erika, Receptor, Receptors, Signal Transduction/drug effects, Song Kwang-Hoon, Strom Stephen, Transcription Factors/metabolism, Tumor, Type 4/antagonists & inhibitors
Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates.
Tags: 2013, Alanine Transaminase/blood, Animals, Biocompatible Materials/chemistry/*metabolism/*toxicity, Cell Line, Chamsaz Elaheh A, Creatine/blood, Cytokines/analysis, Department of Pharmaceutical Sciences, Erythrocytes/drug effects, Hemolysis/drug effects, Inbred BALB C, Journal of pharmaceutical sciences, Joy Abraham, Kidney/drug effects/pathology, Light, Liver/drug effects/pathology, Macrophages/cytology/drug effects, Mice, NEOMED College of Pharmacy, Oyewumi Moses O, Polycarboxylate Cement/chemistry/*metabolism/*toxicity, Rats, Sprague-Dawley, Sun Shuangyi, Wehrung Daniel
Brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles for brain cancers.
Tags: *Drug Delivery Systems, 2015, Animals, Antibiotics, Antineoplastic/*administration & dosage/pharmacokinetics, Blood-Brain Barrier/*metabolism, Brain cancer, Brain Neoplasms/drug therapy/metabolism, brain-targeted delivery, Cell Line, Doxorubicin, Doxorubicin/*administration & dosage/pharmacokinetics, Drug Carriers/*chemistry/metabolism, Geldenhuys Werner, Glutathione/*chemistry/metabolism, Groshev Anastasia, Hirani Anjali, Lactic Acid/chemistry/metabolism, Nanoparticles/*chemistry/metabolism, Pharmaceutical development and technology, PLGA-PEG NP, Polyethylene Glycols/chemistry/metabolism, Polyglycolic Acid/chemistry/metabolism, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Sutariya Vijaykumar, Tumor, Wehrung Daniel
Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.
Tags: *Drug Delivery Systems, 2011, Adenosine Triphosphatases/metabolism, Animals, Antineoplastic Agents, ATP Binding Cassette Transporter, Blood-Brain Barrier/metabolism, Brain Neoplasms/drug therapy, Bui Thong, Cell Death/drug effects, Cell Line, Coumarins/administration & dosage/pharmacokinetics, Delayed-Action Preparations, Geldenhuys Werner, Glioma/drug therapy/pathology, Glutathione/*chemistry, Harrison Kimberly, Humans, Inbred C57BL, Journal of drug targeting, Male, Mbimba Thomas, Member 1/metabolism, Mice, Microtubules/metabolism, Nanoparticles, Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology, Particle Size, Permeability, Phytogenic/administration & dosage/*pharmacokinetics/pharmacology, Rats, Subfamily B, Sutariya Vijaykumar, Thiazoles/administration & dosage/pharmacokinetics, Tubulin/metabolism, Tumor
Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders.
Tags: *Lactic Acid, *Polyglycolic Acid, 2010, Animals, Antibodies, Antioxidants/chemistry/*metabolism, Bhatia Deepak, Bhatia Ruchi, Bishayee Anupam, Blood-Brain Barrier/metabolism, Carroll Richard T, Cell Line, Cross-Linking Reagents/chemistry, Cyclic N-Oxides/chemistry/*metabolism, Delayed-Action Preparations, Free Radical Scavengers/chemistry/*metabolism, Geldenhuys Werner, Journal of drug targeting, Maleimides/chemistry, Miladore Nicholas, Monoclonal/chemistry/*metabolism, Nanoparticles, Particle Size, Polyethylene Glycols, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Spin Labels, Sutariya Vijaykumar, Transferrin/*immunology, Tumor
Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability.
Tags: 2003, Aggrecans, Animals, C-Type, Cell Line, Chondrocytes/*physiology, Collagen Type II/genetics/metabolism, Dactinomycin, Down-Regulation, Extracellular Matrix Proteins/analysis/genetics/*metabolism, Gene Expression Regulation, Glycoproteins/analysis/genetics/*metabolism, High Mobility Group Proteins/genetics/*metabolism, Horton Walter E Jr, Journal of cellular biochemistry, Kinkel Mary D, Lectins, Matrilin Proteins, Messenger/analysis/biosynthesis, Polymerase Chain Reaction/methods, Proteoglycans/genetics/metabolism, Proto-Oncogene Proteins c-bcl-2/deficiency/genetics/*physiology, Rats, RNA, RNA Stability, Signal Transduction, SOX9 Transcription Factor, Transcription Factors/genetics/*metabolism, Transfection
Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Cell Line, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Chromosome Mapping, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Inhibitors/pharmacology, Gene Expression Regulation/*drug effects, Genetic/drug effects, Genetic/physiology, Hepatocyte Nuclear Factor 4, Hepatocytes/metabolism, Humans, Interleukin-1/*pharmacology, Jahan Asmeen, MAP Kinase Signaling System/drug effects/physiology, Messenger/antagonists & inhibitors, Mitogen-Activated Protein Kinase 8/metabolism, Mitogen-Activated Protein Kinases/antagonists & inhibitors, NEOMED College of Medicine, Phosphoproteins/genetics/metabolism, Phosphorylation, Promoter Regions, Response Elements/genetics, RNA, Steroid 12-alpha-Hydroxylase/antagonists & inhibitors/*genetics, Transcription, Transcription Factors/genetics/metabolism
Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.
Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal
Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence.
Tags: 2016, 3T3 Cells, Animals, Cardona Sandra M, Cell Line, Cell Proliferation, Cell Survival, Department of Integrative Medical Sciences, Dunphy Jaclyn M, env/biosynthesis, Female, Gene Products, Journal of virology, Leukemia Virus, Li Ying, Lynch Connor R, Lynch William P, Macklin Wendy B, Male, Mice, Motor Neuron Disease/*virology, Murine/*pathogenicity, NEOMED College of Medicine, Neural Stem Cells/*virology, Neurogenesis/*physiology, Neuroglia/*virology, Oligodendroglia/cytology/virology, Pedraza Carlos E, Retroviridae Infections/*complications, Transgenic
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Tags: 2009, Adenoviridae/genetics, Animals, Bile Acids and Salts/biosynthesis, Biochimica et biophysica acta, Cell Line, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*antagonists & inhibitors/genetics/metabolism, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage/*pharmacology, Down-Regulation/drug effects, Enzymologic/drug effects, Feeding Behavior/*drug effects, Forkhead Box Protein O1, Forkhead Transcription Factors/genetics/*metabolism, Gene Expression Regulation, Gene Knockdown Techniques, Gene Transfer Techniques, Hepatocytes/drug effects/*enzymology, Humans, Inbred C57BL, Insulin Resistance, Insulin/metabolism, Lee Yoon-Kwang, Li Tiangang, Ma Huiyan, Male, Messenger/genetics/metabolism, Mice, Moore David D, NEOMED College of Medicine, Park Young Joo, RNA, RNA Interference/drug effects, Strom Stephen, Tumor
Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates.
Tags: 2014, Animals, Biocompatibility, Cardiotoxicity, Cell Line, Chamsaz Elaheh A, Chemistry, Department of Pharmaceutical Sciences, Dose-Response Relationship, Doxorubicin, Drug, Drug Delivery Systems/*methods, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Heart/drug effects, Humans, Inbred BALB C, Joy Abraham, Mice, Nanotechnology, NEOMED College of Pharmacy, Oyewumi Moses O, Pharmaceutical, Photic Stimulation/*methods, Photoresponsive, Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity, Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity, Polymer chain scission, Stimuli-responsive, Tumor, Wehrung Daniel
Gelucire-stabilized nanoparticles as a potential DNA delivery system.
Tags: *Gene Transfer Techniques, 2016, Animals, Cationic lipids, Cell Line, Cell Survival/drug effects/physiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, DNA/*administration & dosage/chemistry, gene therapy, Hep G2 Cells, Humans, macrophage activation, Macrophages/drug effects/physiology, Mice, Nanoparticles, Nanoparticles/*administration & dosage/chemistry, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Oyewumi Moses O, Pharmaceutical development and technology, Polyethylene Glycols/*administration & dosage/chemistry, Sadana Prabodh, Transfection, Wehrung Daniel
Genomic structure and regulation of the rat hepatic CYP4F1 gene by peroxisome proliferators.
Tags: 2008, Animals, Archives of biochemistry and biophysics, Cell Line, Chen Liping, Chromosome Mapping, Cytochrome P-450 Enzyme System/*genetics, Department of Integrative Medical Sciences, Donelson Ellen, Gene Expression Regulation/drug effects/*genetics, Genetic/*genetics, Goswami Puja, Hardwick James P, Hepatocytes/drug effects/*physiology, Liver/drug effects/*physiology, NEOMED College of Medicine, Peroxisome Proliferator-Activated Receptors/*genetics, Peroxisome Proliferators/*pharmacology, Promoter Regions, Rats, Song Byoung J, Zhang Xiaolan
Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.
Tags: 2003, ATP Binding Cassette Transporter, ATP-Binding Cassette Transporters/*genetics, Biochemical and biophysical research communications, Cell Line, Chenodeoxycholic Acid/antagonists & inhibitors, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, DNA-Binding Proteins/*antagonists & inhibitors/metabolism, Dose-Response Relationship, Drug, Gene Expression Regulation/drug effects, Humans, Member 11, NEOMED College of Medicine, Owsley Erika, Pregnane X Receptor, Pregnenediones/*pharmacology, Receptors, Steroid/*metabolism, Subfamily B, Transcription Factors/*antagonists & inhibitors/metabolism, Transcriptional Activation/drug effects
Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress.
Tags: *ammonia, *ATP, *cellular respiration, *cirrhosis, *Mitochondria, *Oxidative Stress, *portacaval anastamosis, *Reactive oxygen species, *skeletal muscle, 2016, Adenosine Triphosphate/metabolism, Aged, Allawy Allawy, Animals, Cell Line, Cell Respiration, Creatine Kinase/metabolism, Dasarathy Srinivasan, Davuluri Gangarao, Department of Pharmaceutical Sciences, Female, Flask Chris A, Hoppel Charles, Humans, Hyperammonemia/*metabolism, Kasumov Takhar, Kumar Avinash, Liver Cirrhosis/metabolism, Male, Middle Aged, Mitochondria, Muscle, Muscle/*metabolism, Myosin Heavy Chains/metabolism, NAD/metabolism, NEOMED College of Pharmacy, Rats, Reactive Oxygen Species/metabolism, Rennison Julie H, Sandlers Yana, Singh Dharmvir, Skeletal/*metabolism, Sprague-Dawley, Thapaliya Samjhana, The Journal of physiology, Thiobarbituric Acid Reactive Substances/metabolism, Van Wagoner David R
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.
Tags: 2017, ADME, Animals, Antineoplastic Agents/*therapeutic use, Apoptosis, Brain cancer, Brain Neoplasms/*drug therapy/pathology/*secondary, Breast Neoplasms/*pathology, Cell Line, Chemotherapy, CNS, Current cancer drug targets, Department of Anatomy & Neurobiology, distribution, Drug Discovery, Drug Resistance, Female, Geldenhuys Werner J, Griffith Jessica I G, Humans, Lockman Paul R, Mice, NEOMED College of Medicine, Safadi Fayez F, Sondag Gregory R, Terell-Hall Tori B, Tumor, Venishetty Vinay K
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.
Tags: 2010, Absorption, Anderson Jody, Animals, Biological, Cell Line, Cholesterol/*metabolism, Class B/*genetics/metabolism, Coronary Disease/metabolism, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Edwards Peter A, Glucose/metabolism, Gonzalez Frank J, Hepatocyte Nuclear Factor 4/metabolism, Homeostasis, Humans, Lipoproteins/metabolism, Liver/metabolism, Ma Huiyan, Mice, Models, NEOMED College of Medicine, Receptors, Scavenger Receptors, The Journal of biological chemistry, Willson Timothy M, Yin Liya, Zhang Yanqiao
Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.
Tags: *Energy Metabolism, *Membrane potential, *Mitochondria, *Myocardial ischemia and reperfusion, *Oxidative Stress, *pH gradient, *Redox dysfunction, 2017, Aconitate Hydratase/metabolism, Animal, Animals, Basic research in cardiology, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Family & Community Medicine, Department of Integrative Medical Sciences, Disease Models, Electron Transport Chain Complex Proteins/metabolism, Heart/*metabolism/pathology, Hydrogen Peroxide/metabolism, Hydrogen-Ion Concentration, Ionophores/pharmacology, Kang Patrick T, Lin Paul, Male, Mitochondria, Mitochondrial, Myocardial Infarction/*metabolism/pathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Oxidation-Reduction, Potassium/metabolism, Rats, Sprague-Dawley, Superoxides/metabolism
Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells.
Tags: 1996, Biochemical and biophysical research communications, Cell Line, Cinnamates/*pharmacology, Cultured, G2 Phase/*drug effects, Humans, Jamison J M, Koch J A, Lymphocytes/cytology/*drug effects, Mitosis/*drug effects, Monocytes/cytology/drug effects, Rosenthal K S, Summers J L, Transformed, Tumor Cells
Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.
Tags: *Immunity, 2006, Active, Animal, Animals, B-Lymphocytes/immunology, Brain/pathology/*virology, Cell Line, Disease Models, Docherty John J, Encephalitis, Fu Ming Ming, Herpes Simplex/*immunology, Innate, Journal of neurovirology, Kumaraswamy Guttalu K, Mice, Microglia/pathology/virology, Newborn, Simplexvirus/*isolation & purification/physiology, T-Lymphocytes/immunology, Virus Replication
Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation.
Tags: *Cell Differentiation, 2015, Animals, Barbe Mary F, Cell Adhesion, Cell Line, Connective Tissue Growth Factor/chemistry/*metabolism, Core Binding Factor Alpha 1 Subunit/metabolism, Cytoskeleton/*metabolism, Department of Anatomy & Neurobiology, Extracellular Signal-Regulated MAP Kinases/metabolism, Focal Adhesion Protein-Tyrosine Kinases/metabolism, Hendesi Honey, Integrins/*metabolism, Mice, Monroy M Alexandra, NEOMED College of Medicine, Osteoblasts/*cytology/*metabolism, PloS one, Popoff Steven N, rac GTP-Binding Proteins/metabolism, Receptors, Safadi Fayez F, Signal Transduction, Transcriptional Activation, Vitronectin/metabolism
Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of Down syndrome
Tags: 16 mice, 2006, Abnormalities, Acetylcholine, acetylcholine-release, Allen D D, alzheimers-disease, amyloid, antisense, beta-protein, calcium, Cardenas A M, Caviedes P, Caviedes R, Cell Line, de Saint Pierre M, Down syndrome, Journal Article, Journal of neuroscience research, Neurosciences & Neurology, Neurotoxicity, Opazo P, peptide, rat hippocampal slices, root ganglion neurons, Saud K, Segura-Aguilar J
LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model.
Tags: *Cancer Vaccines/genetics/immunology/therapeutic use, 2017, Animal, Animals, Breast Neoplasms/genetics/immunology/prevention & control/therapy, CD8-Positive T-Lymphocytes/immunology, Cell Line, Cytotoxic/immunology, Disease Models, Disease Progression, Epitopes, erbB-2, Experimental/immunology/pathology/*prevention & control/*therapy, Female, Genes, Immunoglobulin G/blood, Inbred BALB C, Journal of immunology research, Koski Gary, Mammary Neoplasms, Mice, Neoplasm Metastasis/prevention & control, Proof of Concept Study, Rosenthal Ken S, Stone Sarah, T-Lymphocyte/immunology, T-Lymphocytes, Tumor, Zimmerman Daniel H
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.
Tags: 2016, Al-Azzam Nosayba, Animals, Boyce Joshua A, c-fos, Capillary Permeability, Cell Line, CysLT(1)R, Department of Integrative Medical Sciences, Dinoprostone/*immunology, Duah Ernest, E-prostanoid receptor 3, Edema/immunology, EP3 Subtype/*immunology, extracellular signal-regulated kinase, Humans, Inbred BALB C, Inbred C57BL, Inflammation/immunology, Kondeti Vinay, leukotriene D(4), Leukotriene D4/*immunology, Leukotriene/*immunology, macrophage inflammatory protein 1beta, Mast cells, Mast Cells/*immunology, Mice, NEOMED College of Medicine, Paruchuri Sailaja, prostaglandin D(2), Prostaglandin E, prostaglandin E(2), protein kinase G, Receptors, The Journal of allergy and clinical immunology, Thodeti Charles K, Transgenic, Tumor
Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-kappaB/HIF-1alpha pathway.
Tags: *Cancer stem cells, *Lipopolysaccharide, *Plasticity, *Stemness maintenance, *Tumor microenvironment, 2016, AC133 Antigen/genetics/*metabolism, alpha Subunit/genetics/*metabolism, Animals, Antineoplastic Agents – Pharmacodynamics, Antineoplastic Agents/pharmacology, Body Weights and Measures, Cancer letters, Carcinoma, Cell Line, Cell Movement – Drug Effects, Cell Movement/drug effects, Cell Physiology, Cell Physiology – Drug Effects, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Drug Resistance, Gene Expression Regulation, Genes, Genetic Techniques, Han Zhi-Peng, Hepatocellular, Hepatocellular – Drug Therapy, Hepatocellular – Metabolism, Hepatocellular – Pathology, Hepatocellular/drug therapy/genetics/*metabolism/pathology, Humans, Hypoxia-Inducible Factor 1, Inbred BALB C, Jing Ying-Ying, Lai Fo-Bao, Li Rong, Li Xiao-Yong, Lipopolysaccharides – Pharmacodynamics, Lipopolysaccharides/*pharmacology, Liu Jing-Feng, Liu Wen-Ting, Liver Neoplasms, Liver Neoplasms – Drug Therapy, Liver Neoplasms – Metabolism, Liver Neoplasms – Pathology, Liver Neoplasms/drug therapy/genetics/*metabolism/pathology, Male, Mice, NEOMED College of Medicine, Neoplasm, Neoplasm Invasiveness, Neoplastic, Neoplastic Stem Cells/*drug effects/metabolism/pathology, NF-kappa B – Metabolism, NF-kappa B/*metabolism, Nude, Pan Xiao-Rong, Phenotype, Proteins, Proteins – Metabolism, RNA Interference, Shi Rong-Yu, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Stem Cells – Drug Effects, Stem Cells – Metabolism, Stem Cells – Pathology, Time Factors, Transfection, Tumor Burden, Tumor Microenvironment, Wei Li-Xin, Wu Meng-Chao, Yang Xue, Yu Guo-Feng, Zeng Jian-Xing, Zhang Hang-Jie, Zhang Ping, Zhao Qiu-Dong
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: 2009, Base Sequence, Calcitriol/drug effects/genetics/*physiology, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cultured, Department of Integrative Medical Sciences, DNA Primers, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Gene Knockdown Techniques, Genetic/*physiology, Han Shuxin, Hepatocytes/*drug effects/enzymology, Humans, Immunoprecipitation, Lithocholic Acid/pharmacology, Messenger/genetics, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, RNA, Small Interfering, Transcription, Tumor, Two-Hybrid System Techniques
Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.
Tags: 1989, Animals, Cell Line, Electron, Electrophoresis, Endocytosis, Glycoproteins/analysis, Glycosylation, Gyurgyik L, Hodnichak C M, Humans, Hydrogen-Ion Concentration, Janiga K, Killius J, Microscopy, Polyacrylamide Gel, Rosenthal K S, Simplexvirus/*physiology/ultrastructure, Temperature, The Journal of general virology, Time Factors, Venetta T M, Vero Cells, Viral Proteins/analysis/metabolism
MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor.
Tags: 2015, Carson Mary, Carson William E 3rd, Cell Line, Cell Movement/genetics, Cell Proliferation/genetics, Chan Anthony N, Dao Thao-Vi, Fairchild Ene T, Ganju Akaansha, Gene Expression Regulation, Grignol Valerie P, Humans, Jaime-Ramirez Alena Cristina, Karpa Volodymyr I, Latchana Nicholas, Levine Kala M, Martin del Campo Sara E, Melanoma/*genetics/metabolism/pathology, MicroRNAs/*genetics/metabolism, Neoplasm Invasiveness/*genetics/pathology, Neoplastic, PloS one, RNA, Skin Neoplasms/*genetics/metabolism/pathology, Small Interfering, Tissue Inhibitor of Metalloproteinase-3/*genetics/metabolism, Tumor
Misfolding of CasBrE SU is reversed by interactions with 4070A Env: implications for gammaretroviral neuropathogenesis.
Tags: 2010, Animals, Cell Line, Department of Integrative Medical Sciences, env/*metabolism, Experimental/*virology, Gene Products, Helper Viruses/metabolism/pathogenicity/*physiology, Leukemia, Leukemia Virus, Li Ying, Lynch William P, Mice, Motor Neuron Disease/*virology, Murine/metabolism/pathogenicity/*physiology, NEOMED College of Medicine, Neural Stem Cells/*virology, Protein Binding, Protein Folding, Protein Subunits/metabolism, Retroviridae Infections/*virology, Retrovirology, Tumor Virus Infections/*virology, Virulence
Natural cytotoxins in human plasma: isolation and characterization of phospholipids associated with cytotoxic lipoproteins.
Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration.
Tags: *Gene Transfer Techniques, *Genes, *Microglia/cytology, *Stem Cells/cytology, 1999, Animals, Cell Line, env, Hematopoietic Stem Cell Transplantation, Journal of virology, Lynch W P, Mice, Nerve Degeneration, Retroviridae Infections/pathology/*virology, Retroviridae/genetics/*physiology, Sharpe A H, Snyder E Y
Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia.
Tags: *Acute lymphoblastic leukemia, *Cancer, *Co-culture model, *Lipids, *Lipoprotein lipase, *Metabolism, 2018, Amides/chemistry/metabolism/pharmacology, Antineoplastic Agents/*chemistry/metabolism/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Coculture Techniques, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dyslipidemias/complications/metabolism/pathology, Geldenhuys Werner J, Gibson Laura F, Humans, Lipoprotein Lipase/antagonists & inhibitors/*metabolism, Mesenchymal Stem Cells/cytology/metabolism, Molecular Docking Simulation, Nair Rajesh R, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Piktel Debbie, Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/metabolism/pathology, Protein Binding, Protein Structure, Sadana Prabodh, Serum Albumin/chemistry/metabolism, Tertiary, Tumor