1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/me.2009-0482" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/me.2009-0482</a>
Pages
1151–1164
Issue
6
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Publisher
An entity responsible for making the resource available
Molecular endocrinology (Baltimore, Md.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
Calcitriol/*metabolism; Calcitriol/pharmacology; Cell Membrane/drug effects/metabolism; Cell Nucleus/drug effects/metabolism; Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics; Enzyme Activation/drug effects; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Genetic/genetics; Hep G2 Cells; Hepatocyte Nuclear Factor 4/metabolism; Hepatocytes/*drug effects/enzymology/*metabolism; Humans; Intracellular Space/drug effects/metabolism; Ligands; Lithocholic Acid/*pharmacology; Mitogen-Activated Protein Kinase Kinases/metabolism; Phosphorylation/drug effects; Phosphotyrosine/metabolism; Promoter Regions; Protein Kinase Inhibitors/pharmacology; Protein Transport/drug effects; Proto-Oncogene Proteins c-raf/metabolism; Receptors; Retinoid X Receptor alpha/metabolism; Signal Transduction/*drug effects; src-Family Kinases/metabolism; Steroid Hydroxylases/genetics/metabolism; Vitamin D3 24-Hydroxylase
Creator
An entity primarily responsible for making the resource
Han Shuxin; Li Tiangang; Ellis Ewa; Strom Stephen; Chiang John Y L
Description
An account of the resource
Vitamin D receptor (VDR) is activated by natural ligands, 1alpha,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/me.2009-0482" target="_blank" rel="noreferrer noopener">10.1210/me.2009-0482</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Calcitriol/*metabolism
Calcitriol/pharmacology
Cell Membrane/drug effects/metabolism
Cell Nucleus/drug effects/metabolism
Chiang John Y L
Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics
Department of Integrative Medical Sciences
Ellis Ewa
Enzyme Activation/drug effects
Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors
Genetic/genetics
Han Shuxin
Hep G2 Cells
Hepatocyte Nuclear Factor 4/metabolism
Hepatocytes/*drug effects/enzymology/*metabolism
Humans
Intracellular Space/drug effects/metabolism
Li Tiangang
Ligands
Lithocholic Acid/*pharmacology
Mitogen-Activated Protein Kinase Kinases/metabolism
Molecular endocrinology (Baltimore, Md.)
NEOMED College of Medicine
Phosphorylation/drug effects
Phosphotyrosine/metabolism
Promoter Regions
Protein Kinase Inhibitors/pharmacology
Protein Transport/drug effects
Proto-Oncogene Proteins c-raf/metabolism
Receptors
Retinoid X Receptor alpha/metabolism
Signal Transduction/*drug effects
src-Family Kinases/metabolism
Steroid Hydroxylases/genetics/metabolism
Strom Stephen
Vitamin D3 24-Hydroxylase
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/jpet.102.040378" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/jpet.102.040378</a>
Pages
1155–1162
Issue
3
Volume
303
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel mechanism of neurokinin-1 receptor resensitization.
Publisher
An entity responsible for making the resource available
The Journal of pharmacology and experimental therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
Animals; Cell Membrane/drug effects/metabolism; CHO Cells; Concanavalin A/pharmacology; Cricetinae; Monensin/pharmacology; Neurokinin-1/*agonists/*metabolism; Phosphorylation/drug effects; Rats; Receptors
Creator
An entity primarily responsible for making the resource
Bennett V J; Perrine S A; Simmons M A
Description
An account of the resource
Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the mechanisms of desensitization and resensitization of the neurokinin-1 receptor. Con A inhibits internalization, whereas monensin prevents receptor recycling. The effects of Con A and monensin on desensitization, resensitization, receptor phosphorylation, endocytosis, and recycling of the neurokinin-1 receptor were assessed. Desensitization was defined as the decrease in the ability of substance P (SP) to elicit an intracellular Ca2+ response after a prolonged SP exposure. Resensitization was characterized as the return of SP responsiveness. Under control conditions, desensitization occurred after a 5-min exposure to agonist. Resensitization was evident 30 min after agonist washout. Neither monensin nor Con A prevented desensitization. Monensin completely inhibited resensitization, whereas Con A decreased but did not completely block resensitization. Receptor phosphorylation was increased after agonist activation and returned to basal levels after a recovery period. Neither Con A nor monensin altered the amount of agonist-specific receptor phosphorylation. Receptor binding analysis showed that plasma membrane receptors were internalized after a 5-min agonist exposure. Receptor recycling was not observed after a 1-h recovery period; however, resensitization was apparent. Taken together, these results suggest that rapid neurokinin-1 receptor desensitization can occur without receptor internalization and that resensitization occurs before receptor recycling.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/jpet.102.040378" target="_blank" rel="noreferrer noopener">10.1124/jpet.102.040378</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Animals
Bennett V J
Cell Membrane/drug effects/metabolism
CHO Cells
Concanavalin A/pharmacology
Cricetinae
Monensin/pharmacology
Neurokinin-1/*agonists/*metabolism
Perrine S A
Phosphorylation/drug effects
Rats
Receptors
Simmons M A
The Journal of pharmacology and experimental therapeutics