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40
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Text
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Pages
159–173
Issue
1
Volume
9
Dublin Core
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Title
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Scanning electron microscopy and transmission electron microscopy aspects of synergistic antitumor activity of vitamin C - vitamin K3 combinations against human prostatic carcinoma cells.
Publisher
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Scanning microscopy
Date
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1995
1995-03
Subject
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Humans; Male; Antineoplastic Agents/*pharmacology; Drug Synergism; Coloring Agents; Ascorbic Acid/*pharmacology; Carcinoma/*drug therapy/pathology; Cell Membrane/drug effects/ultrastructure; Cytoskeleton/drug effects/ultrastructure; Mitochondria/drug effects/ultrastructure; Prostatic Neoplasms/*drug therapy/pathology; Tetrazolium Salts; Thiazoles; Vitamin K/*pharmacology; Microscopy; Electron; Cultured; Scanning; Tumor Cells; Drug Therapy; Combination
Creator
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Gilloteaux J; Jamison J M; Venugopal M; Giammar D; Summers J L
Description
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A MTT/formazan assay was used to evaluate the antitumor activity of vitamin C (Vit C), vitamin K3 (Vit K3), or vitamin C:vitamin K3 combinations against a human prostatic carcinoma cell line (DU145). Both Vit C and Vit K3 alone exhibited antitumor activity, but only at elevated doses. When Vit C and Vit K3 were combined at a C:K3 ratio of 100:1 and administered to the carcinoma cells, the 50% cytotoxic concentrations (CD50) of the vitamins decreased 10- to 60-fold. Subsequently, the DU145 cells were examined with transmission and scanning electron microscopy (TEM and SEM) following a 1 hour treatment with Vit C, Vit K3, or Vit C/K3 combined at their 50% cytotoxic dose. Our morphological data suggest that vitamin treatment with individual vitamins affects the cytoskeleton, the mitochondria, and other membranous components of the cell. Treatment with the vitamin combination appears to potentiate the effects of the individual vitamin treatment. Specifically, there are abundant necrotic cells. The surviving cells display morphological defects characteristic of cell injury.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Antineoplastic Agents/*pharmacology
Ascorbic Acid/*pharmacology
Carcinoma/*drug therapy/pathology
Cell Membrane/drug effects/ultrastructure
Coloring Agents
Combination
Cultured
Cytoskeleton/drug effects/ultrastructure
Drug Synergism
Drug Therapy
Electron
Giammar D
Gilloteaux J
Humans
Jamison J M
Male
Microscopy
Mitochondria/drug effects/ultrastructure
Prostatic Neoplasms/*drug therapy/pathology
Scanning
Scanning microscopy
Summers J L
Tetrazolium Salts
Thiazoles
Tumor Cells
Venugopal M
Vitamin K/*pharmacology