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Text
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URL Address
<a href="http://doi.org/10.1089/jmf.2012.0303" target="_blank" rel="noreferrer noopener">http://doi.org/10.1089/jmf.2012.0303</a>
Pages
1079–1085
Issue
12
Volume
16
Dublin Core
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Title
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Antimicrobial Effects of Virgin Coconut Oil and Its Medium-Chain Fatty Acids on Clostridium difficile.
Publisher
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Journal of Medicinal Food
Date
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2013
2013-12
Subject
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Staining and Labeling; Microscopy; Descriptive Statistics; Comparative Studies; Microbial Culture and Sensitivity Tests; In Vitro Studies; Alternative Therapies; Cell Membrane; Coconut; Clostridium Infections – Prevention and Control; Antiinfective Agents – Pharmacodynamics; Fatty Acids – Analysis; Lipids – Pharmacodynamics; Plant Oils – Pharmacodynamics
Creator
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Shilling Michael; Matt Laurie; Rubin Evelyn; Visitacion Mark Paul; Haller Nairmeen A; Grey Scott F; Woolverton Christopher J
Description
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Clostridium difficile is the leading cause of hospital-acquired antibiotic-associated diarrhea worldwide; in addition, the proliferation of antibiotic-resistant C. difficile is becoming a significant problem. Virgin coconut oil (VCO) has been shown previously to have the antimicrobial activity. This study evaluates the lipid components of VCO for the control of C. difficile. VCO and its most active individual fatty acids were tested to evaluate their antimicrobial effect on C. difficile in vitro. The data indicate that exposure to lauric acid (C12) was the most inhibitory to growth ( P\textless.001), as determined by a reduction in colony-forming units per milliliter. Capric acid (C10) and caprylic acid (C8) were inhibitory to growth, but to a lesser degree. VCO did not inhibit the growth of C. difficile; however, growth was inhibited when bacterial cells were exposed to 0.15-1.2% lipolyzed coconut oil. Transmission electron microscopy (TEM) showed the disruption of both the cell membrane and the cytoplasm of cells exposed to 2 mg/mL of lauric acid. Changes in bacterial cell membrane integrity were additionally confirmed for VCO and select fatty acids using Live/Dead staining. This study demonstrates the growth inhibition of C. difficile mediated by medium-chain fatty acids derived from VCO.
Identifier
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<a href="http://doi.org/10.1089/jmf.2012.0303" target="_blank" rel="noreferrer noopener">10.1089/jmf.2012.0303</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Alternative Therapies
Antiinfective Agents – Pharmacodynamics
Cell Membrane
Clostridium Infections – Prevention and Control
Coconut
Comparative Studies
Descriptive Statistics
Fatty Acids – Analysis
Grey Scott F
Haller Nairmeen A
In Vitro Studies
Journal of Medicinal Food
Lipids – Pharmacodynamics
Matt Laurie
Microbial Culture and Sensitivity Tests
Microscopy
Plant Oils – Pharmacodynamics
Rubin Evelyn
Shilling Michael
Staining and Labeling
Visitacion Mark Paul
Woolverton Christopher J