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Text
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URL Address
<a href="http://doi.org/10.1152/ajpcell.00256.2014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpcell.00256.2014</a>
Pages
C111–122
Issue
2
Volume
308
Dublin Core
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Title
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Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Publisher
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American journal of physiology. Cell physiology
Date
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2015
2015-01
Subject
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Aorta/drug effects/metabolism; Cell Proliferation/*drug effects/genetics; Cells; Chromium/*pharmacology; Cultured; Fructosephosphates/metabolism; Genetic/drug effects/genetics; Glucose/*metabolism; Glutamine/genetics; Glycosylation/drug effects; Hexosamines/metabolism; Humans; Hyperglycemia/metabolism; Muscle; Myocytes; N-Acetylglucosaminyltransferases/genetics; O-glycosylation; Promoter Regions; reactive oxygen species; Reactive Oxygen Species/metabolism; Signal Transduction/*drug effects/genetics; Smooth; Smooth Muscle/*drug effects/metabolism; Thrombospondin 1/*antagonists & inhibitors/genetics; thrombospondin-1; Transcription; trivalent chromium; vascular smooth muscle cells; Vascular/*drug effects/metabolism
Creator
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Ganguly Rituparna; Sahu Soumyadip; Chavez Ronaldo J; Raman Priya
Description
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Trivalent chromium (Cr(3+)) is a mineral nutrient reported to have beneficial effects in glycemic and cardiovascular health. In vitro and in vivo studies suggest that Cr(3+) supplementation reduces the atherogenic potential and lowers the risk of vascular inflammation in diabetes. However, effects of Cr(3+) in vascular cells under conditions of hyperglycemia, characteristic of diabetes, remain unknown. In the present study we show that a therapeutically relevant concentration of Cr(3+) (100 nM) significantly downregulates a potent proatherogenic matricellular protein, thrombospondin-1 (TSP-1), in human aortic smooth muscle cells (HASMC) stimulated with high glucose in vitro. Promoter-reporter assays reveal that this downregulation of TSP-1 expression by Cr(3+) occurs at the level of transcription. The inhibitory effects of Cr(3+) on
Identifier
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<a href="http://doi.org/10.1152/ajpcell.00256.2014" target="_blank" rel="noreferrer noopener">10.1152/ajpcell.00256.2014</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
American journal of physiology. Cell physiology
Aorta/drug effects/metabolism
Cell Proliferation/*drug effects/genetics
Cells
Chavez Ronaldo J
Chromium/*pharmacology
Cultured
Department of Integrative Medical Sciences
Fructosephosphates/metabolism
Ganguly Rituparna
Genetic/drug effects/genetics
Glucose/*metabolism
Glutamine/genetics
Glycosylation/drug effects
Hexosamines/metabolism
Humans
Hyperglycemia/metabolism
Muscle
Myocytes
N-Acetylglucosaminyltransferases/genetics
NEOMED College of Medicine
O-glycosylation
Promoter Regions
Raman Priya
reactive oxygen species
Reactive Oxygen Species/metabolism
Sahu Soumyadip
Signal Transduction/*drug effects/genetics
Smooth
Smooth Muscle/*drug effects/metabolism
Thrombospondin 1/*antagonists & inhibitors/genetics
thrombospondin-1
Transcription
trivalent chromium
vascular smooth muscle cells
Vascular/*drug effects/metabolism