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Text
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URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2010.02.076</a>
Pages
985–993
Issue
4
Volume
167
Dublin Core
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Title
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Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.
Publisher
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Neuroscience
Date
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2010
2010-06
Subject
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3; 4-Dihydroxyphenylacetic Acid/metabolism; Age Factors; Animals; Body Temperature/drug effects; Central Nervous System Stimulants/*toxicity; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; In Vitro Techniques; Male; Methamphetamine/*toxicity; Mice; Neurotoxicity Syndromes/etiology/*metabolism/physiopathology; Sex Factors; Time Factors
Creator
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Dluzen D E; McDermott J L; Darvesh A S
Description
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A neurotoxic regimen of methamphetamine (MA-40 mg/kg ip) administered at 0 (control-MA vehicle), 0.5 and 72 h prior to determinations of striatal dopamine (DA) and DOPAC (3,4-dihydroxyphenylacetic acid)/DA ratios were compared among juvenile and adult female and male mice. Adult females and males showed similar depletions in striatal DA at 0.5 h post-MA, but males showed greater DA depletions and DOPAC/DA ratios at 72 h post-MA. Juvenile mice showed neither sex differences, nor any MA neurotoxicity upon striatal DA or DOPAC/DA ratios. Following MA, body temperatures increased in all mice, but increases in adult males were greater than adult females; juveniles showed no sex differences and body temperature increases were similar to that of adult males. MA-evoked DA output was greater in adult compared to juvenile males and a biologically effective regimen of testosterone to juvenile males neither increased MA-evoked DA output nor decreased MA-induced striatal DA like that observed in adult males. These results demonstrate: (1) Unlike adults, juvenile mice show neither a sex difference for MA-induced neurotoxicity or body temperature increases, nor MA neurotoxicity, (2) Initial effects of MA (0.5 h) in adult females and males are similar, but at 72 h post-MA females show no further striatal DA depletion, (3) Increased striatal DA depletion within adult versus juvenile males may be related to initially higher MA-evoked DA responses, and (4) Testosterone fails to convert juvenile males into adults with regard to MA effects.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2010.02.076</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/metabolism
Age Factors
Animals
Body Temperature/drug effects
Central Nervous System Stimulants/*toxicity
Corpus Striatum/*drug effects/metabolism
Darvesh A S
Department of Pharmaceutical Sciences
Dluzen D E
Dopamine/*metabolism
Female
In Vitro Techniques
Male
McDermott J L
Methamphetamine/*toxicity
Mice
NEOMED College of Pharmacy
Neuroscience
Neurotoxicity Syndromes/etiology/*metabolism/physiopathology
Sex Factors
Time Factors