Conditioned place preference produced by the psychostimulant cathinone.
Alkaloids/administration & dosage/*pharmacology; Animals; Central Nervous System Stimulants/administration & dosage/*pharmacology; Choice Behavior/drug effects; Conditioning (Psychology)/drug effects; Dose-Response Relationship; Drug; Habituation; Male; Motor Activity/*drug effects; Psychophysiologic; Rats; Sprague-Dawley
Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced conditioned place preference, as well as testing its effect upon spontaneous locomotor activity. At doses ranging from 0.2 to 1.6 mg/kg, cathinone produced a conditioned place preference at all but the lowest dose, and the highest dose but not the lowest dose increased locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and the relationship between conditioned place preference and locomotion being subserved by the same neuronal system.
Schechter M D; Meehan S M
European journal of pharmacology
1993
1993-02
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0014-2999(93)90739-5" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(93)90739-5</a>
Dopaminergic mediation of the stimulant generalization of nicotine.
Alkaloids/pharmacology; Animals; Central Nervous System Stimulants/administration & dosage/*pharmacology; Cues; Discrimination (Psychology)/drug effects; Dopamine/*physiology; Dose-Response Relationship; Drug; Generalization (Psychology)/*drug effects; Injections; Intraperitoneal; Male; Nicotine/administration & dosage/*pharmacology; Rats; Sprague-Dawley; Thiazepines/pharmacology
1. Experiments were conducted to investigate if the psychostimulant cathinone, like d-amphetamine, would produce generalization of the discriminative stimulus effects of nicotine. 2. Rats were trained to discriminate either 0.8 mg/kg cathinone from its vehicle or 0.8 mg/kg nicotine from its vehicle and, subsequently, administered various doses of the other compound. 3. Results of Exp 1 indicate that animals trained to discriminate cathinone only partially generalize to the effects of 0.8-1.6 mg/kg nicotine. In contrast, animals trained to discriminate nicotine dose-responsively generalize to cathinone doses ranging from 0.1-1.2 mg/kg. 4. Exp 2 served to investigate the effects of the dopamine release inhibiting drug CGS 10746B upon the observed cathinone generalization in nicotine-trained rats. Pretreatment with this compound at doses of 20 and 30 mg/kg significantly attenuated cathinone generalization in these animals. 5. The results are discussed in light of the growing evidence that nicotinic receptors reside upon mesolimbic dopamine neurons and the possibility that the consequent increase in extracellular dopamine may produce the discriminative stimuli, as well as the reinforcing properties, of nicotine.
Schechter M D; Meehan S M
Progress in neuro-psychopharmacology & biological psychiatry
1993
1993-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0278-5846(93)90064-y" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(93)90064-y</a>
Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.
*Dopamine Antagonists; Alkaloids/administration & dosage/*pharmacology; Animals; Antipsychotic Agents/pharmacology; Central Nervous System Stimulants/administration & dosage/*pharmacology; Conditioning; Discrimination (Psychology)/drug effects; Dose-Response Relationship; Drug; Injections; Intraventricular; Male; Operant/*drug effects; Rats; Sprague-Dawley; Thiazepines/pharmacology
1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats conditioned with 16 or 32 micrograms doses of CATH significantly increased the time spent in their less preferred side, whereas rats conditioned with the 8.0 micrograms dose failed to show any shift from baseline preference. The 16 and 32 micrograms doses of CATH also significantly (p \textless .004) increased activity by more than 65% of baseline. 2. Exp. 2 was designed to determine whether ICV pretreatment with a dopamine release inhibitor CGS 10746B (CGS; 15 micrograms/rat) would block place conditioning produced by CATH. The results demonstrate that CGS pretreatment effectively blocked CATH-induced place conditioning and the CATH-induced elevation of activity.
Calcagnetti D J; Schechter M D
Progress in neuro-psychopharmacology & biological psychiatry
1993
1993-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0278-5846(93)90011-g" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(93)90011-g</a>