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40
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Text
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Pages
43–46
Issue
1
Volume
154
Dublin Core
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Title
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Developmental alterations in N-methyl-D-aspartate stimulated [3H]norepinephrine release in rat brain cortex and hippocampus.
Publisher
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Neuroscience letters
Date
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1993
1993-05
Subject
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Female; Male; Animals; Rats; In Vitro Techniques; 2-Amino-5-phosphonovalerate/pharmacology; Norepinephrine/*metabolism; N-Methylaspartate/*pharmacology; Cerebral Cortex/drug effects/*growth & development/metabolism; Hippocampus/drug effects/*growth & development/metabolism; Sprague-Dawley
Creator
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Brown L M
Description
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Developmental alterations in N-methyl-D-aspartate (NMDA)-stimulated[3H]norepinephrine release from rat brain cortical and hippocampal slices were studied. NMDA (10-1000 microM) resulted in a concentration-dependent increase in [3H]norepinephrine efflux; maximal responses (% released) in the cortex were: (1.53 +/- 0.12, 3.68 +/- 0.20, 2.94 +/- 0.20, 4.60 +/- 0.28 and 5.28 +/- 0.33) and the hippocampal responses were: (1.90 +/- 0.18, 3.84 +/- 0.23, 3.60 +/- 0.28, 5.16 +/- 0.38 and 5.81 +/- 0.45) at varying postnatal ages (1, 7, 14, 21 and 90 days) respectively. Cortical tissue from
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
2-Amino-5-phosphonovalerate/pharmacology
Animals
Brown L M
Cerebral Cortex/drug effects/*growth & development/metabolism
Female
Hippocampus/drug effects/*growth & development/metabolism
In Vitro Techniques
Male
N-Methylaspartate/*pharmacology
Neuroscience letters
Norepinephrine/*metabolism
Rats
Sprague-Dawley